Observation of a power-law memory kernel for fluctuations within a single protein molecule
The fluctuation of the distance between a fluorescein-tyrosine pair within a single protein complex was directly monitored in real time by photoinduced electron transfer and found to be a stationary, time-reversible, and non-Markovian Gaussian process. Within the generalized Langevin equation formal...
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| Veröffentlicht in: | Physical review letters 2005-05, Vol.94 (19), p.198302.1-198302.4, Article 198302 |
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| container_end_page | 198302.4 |
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| container_issue | 19 |
| container_start_page | 198302.1 |
| container_title | Physical review letters |
| container_volume | 94 |
| creator | WEI MIN GUOBIN LUO CHERAYIL, Binny J KOU, S. C XIE, X. Sunney |
| description | The fluctuation of the distance between a fluorescein-tyrosine pair within a single protein complex was directly monitored in real time by photoinduced electron transfer and found to be a stationary, time-reversible, and non-Markovian Gaussian process. Within the generalized Langevin equation formalism, we experimentally determine the memory kernel K(t), which is proportional to the autocorrelation function of the random fluctuating force. K(t) is a power-law decay, t(-0.51 +/- 0.07) in a broad range of time scales (10(-3)-10 s). Such a long-time memory effect could have implications for protein functions. |
| doi_str_mv | 10.1103/physrevlett.94.198302 |
| format | Article |
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Psychology</subject><subject>General aspects, investigation methods</subject><subject>Models, Biological</subject><subject>Models, Chemical</subject><subject>Protein Conformation</subject><subject>Proteins</subject><subject>Proteins - chemistry</subject><subject>Streptavidin - chemistry</subject><subject>Thermodynamics</subject><subject>Tyrosine - chemistry</subject><issn>0031-9007</issn><issn>1079-7114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkFtrGzEQRkVoiJ3LT2jQS_O2jm570WMwbRowOITkpS_LrHZUb6NdOdKujf991drQwsDAcL6Z4RDymbMF50zebzeHGHDncBwXWi24riQTZ2TOWamzknP1icwZkzzTjJUzchnjL8YYF0V1QWa8YJoJwefkx7qJGHYwdn6g3lKgW7_HkDnY0x57Hw70HcOAjlofqHWTGae_cKT7btx0Q0rEbvjpkG6DHzENeu_QTA6vybkFF_Hm1K_I27evr8vv2Wr9-LR8WGVG5fmYGd1qyyEHZQpoJMiqgka3AGBbVFwDtkaAlYhCm1JXylRgGo5CKsFEDvKK3B33pgc-Joxj3XfRoHMwoJ9iXVSqKFIlMD-CJviY5Nl6G7oewqHmrP4jtX5OUl9wt0pSa63qo9SUuz0dmJoe23-pk8UEfDkBEA04G2AwXfyPq_KSSyZ_Awvvhhc</recordid><startdate>20050520</startdate><enddate>20050520</enddate><creator>WEI MIN</creator><creator>GUOBIN LUO</creator><creator>CHERAYIL, Binny J</creator><creator>KOU, S. 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Psychology</topic><topic>General aspects, investigation methods</topic><topic>Models, Biological</topic><topic>Models, Chemical</topic><topic>Protein Conformation</topic><topic>Proteins</topic><topic>Proteins - chemistry</topic><topic>Streptavidin - chemistry</topic><topic>Thermodynamics</topic><topic>Tyrosine - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WEI MIN</creatorcontrib><creatorcontrib>GUOBIN LUO</creatorcontrib><creatorcontrib>CHERAYIL, Binny J</creatorcontrib><creatorcontrib>KOU, S. C</creatorcontrib><creatorcontrib>XIE, X. 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Sunney</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Observation of a power-law memory kernel for fluctuations within a single protein molecule</atitle><jtitle>Physical review letters</jtitle><addtitle>Phys Rev Lett</addtitle><date>2005-05-20</date><risdate>2005</risdate><volume>94</volume><issue>19</issue><spage>198302.1</spage><epage>198302.4</epage><pages>198302.1-198302.4</pages><artnum>198302</artnum><issn>0031-9007</issn><eissn>1079-7114</eissn><coden>PRLTAO</coden><abstract>The fluctuation of the distance between a fluorescein-tyrosine pair within a single protein complex was directly monitored in real time by photoinduced electron transfer and found to be a stationary, time-reversible, and non-Markovian Gaussian process. Within the generalized Langevin equation formalism, we experimentally determine the memory kernel K(t), which is proportional to the autocorrelation function of the random fluctuating force. 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| ispartof | Physical review letters, 2005-05, Vol.94 (19), p.198302.1-198302.4, Article 198302 |
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| source | MEDLINE; American Physical Society Journals |
| subjects | Analytical, structural and metabolic biochemistry Antibodies, Monoclonal - chemistry Biological and medical sciences Biotin - chemistry Fluorescein - chemistry Fundamental and applied biological sciences. Psychology General aspects, investigation methods Models, Biological Models, Chemical Protein Conformation Proteins Proteins - chemistry Streptavidin - chemistry Thermodynamics Tyrosine - chemistry |
| title | Observation of a power-law memory kernel for fluctuations within a single protein molecule |
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