Diverse TNFalpha-induced death pathways are enhanced by inhibition of NF-kappaB

TNFalpha was initially described as inducing necrotic death in tumors in vivo, and more recently as a cytokine that mediates cytoprotection and inflammation. The anti-tumor effects of TNFalpha are poorly characterized because TNFalpha-induced death of human tumor cells has largely been studied in th...

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Veröffentlicht in:	International journal of oncology 2007-12, Vol.31 (6), p.1519-1528
Hauptverfasser:	Katdare, Mukta, Efimova, Elena V, Labay, Edwardine, Khodarev, Nikolai N, Darga, Thomas E, Garofalo, Michael, Nakamura, Satoaki, Kufe, Donald W, Posner, Mitchell C, Weichselbaum, Ralph R
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Cell Line, Tumor Cell Survival - drug effects Cellular Senescence - drug effects Humans Imidazoles - pharmacology Necrosis Neoplasms - drug therapy Neoplasms - pathology NF-kappa B - antagonists & inhibitors NF-kappa B - physiology Quinoxalines - pharmacology Tumor Necrosis Factor-alpha - pharmacology
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