Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race
Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways to regulate gene expression, to mediate antiviral responses, to organize chromosomal domains, and to restrain the spread of selfish genetic elements. Historically, RNAi has been defined as a response to double-s...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2007-11, Vol.318 (5851), p.761-764 |
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| creator | Aravin, Alexei A Hannon, Gregory J Brennecke, Julius |
| description | Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways to regulate gene expression, to mediate antiviral responses, to organize chromosomal domains, and to restrain the spread of selfish genetic elements. Historically, RNAi has been defined as a response to double-stranded RNA. However, some small RNA species may not arise from double-stranded RNA precursors. Yet, like microRNAs and small interfering RNAs, such species guide Argonaute proteins to silencing targets through complementary base-pairing. Silencing can be achieved by corecruitment of accessory factors or through the activity of Argonaute itself, which often has endonucleolytic activity. As a specific and adaptive regulatory system, RNAi is used throughout eukarya, which indicates a long evolutionary history. A likely function of RNAi throughout that history is to protect the genome from both pathogenic and parasitic invaders. |
| doi_str_mv | 10.1126/science.1146484 |
| format | Article |
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Historically, RNAi has been defined as a response to double-stranded RNA. However, some small RNA species may not arise from double-stranded RNA precursors. Yet, like microRNAs and small interfering RNAs, such species guide Argonaute proteins to silencing targets through complementary base-pairing. Silencing can be achieved by corecruitment of accessory factors or through the activity of Argonaute itself, which often has endonucleolytic activity. As a specific and adaptive regulatory system, RNAi is used throughout eukarya, which indicates a long evolutionary history. 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Transposable element ; Genomes ; Genomics ; Germ cells ; Mammals ; MicroRNA ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Pachytene stage ; Proteins ; Proteins - genetics ; Proteins - physiology ; Review ; Ribonucleic acid ; RNA ; RNA, Small Interfering ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - physiology ; RNA-Induced Silencing Complex ; Small interfering RNA ; Transposons</subject><ispartof>Science (American Association for the Advancement of Science), 2007-11, Vol.318 (5851), p.761-764</ispartof><rights>Copyright 2007 American Association for the Advancement of Science</rights><rights>2008 INIST-CNRS</rights><rights>Copyright © 2007, American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c525t-160fbf6b7886cfa064c2c3a5f71dd825f5f6edc896cf79b4b5af136a902b127c3</citedby><cites>FETCH-LOGICAL-c525t-160fbf6b7886cfa064c2c3a5f71dd825f5f6edc896cf79b4b5af136a902b127c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/20051496$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/20051496$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2882,2883,27922,27923,58015,58248</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19219172$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17975059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aravin, Alexei A</creatorcontrib><creatorcontrib>Hannon, Gregory J</creatorcontrib><creatorcontrib>Brennecke, Julius</creatorcontrib><title>Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways to regulate gene expression, to mediate antiviral responses, to organize chromosomal domains, and to restrain the spread of selfish genetic elements. 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A likely function of RNAi throughout that history is to protect the genome from both pathogenic and parasitic invaders.</description><subject>Adaptation, Biological</subject><subject>Animals</subject><subject>Argonaute Proteins</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>DNA Transposable Elements</subject><subject>Drosophila</subject><subject>Drosophila Proteins</subject><subject>Evolution, Molecular</subject><subject>Evolutionary biology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Silencing</subject><subject>Genetic loci</subject><subject>Genic rearrangement. Recombination. Transposable element</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Germ cells</subject><subject>Mammals</subject><subject>MicroRNA</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Pachytene stage</subject><subject>Proteins</subject><subject>Proteins - genetics</subject><subject>Proteins - physiology</subject><subject>Review</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA, Small Interfering</subject><subject>RNA-Binding Proteins - genetics</subject><subject>RNA-Binding Proteins - physiology</subject><subject>RNA-Induced Silencing Complex</subject><subject>Small interfering RNA</subject><subject>Transposons</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1rFDEYBvAgFrtWz57UINjb2DfJ5Ou41FaLRZfankMmk9gsu5MxmW3pf29kBwteegrD85s35HkRekPgEyFUnBQX_eB8_WhFq9pnaEFA80ZTYM_RAoCJRoHkh-hlKWuAmmn2Ah0SqSUHrhfo2yrex2aMV9-XeGWn23v7gFc53cXeF2wHvOztOMU7jz_74IficRzwdOvxdbZDGVNJleRtwVfW-VfoINhN8a_n8wjdnJ9dn35tLn98uThdXjaOUz41REDoguikUsIFC6J11DHLgyR9rygPPAjfO6VrKnXXdtwGwoTVQDtCpWNH6Hg_d8zp986XyWxjcX6zsYNPu2KEagUnRD4JKSitWqor_PAfXKddHuojDK1XA6ttVXSyRy6nUrIPZsxxa_ODIWD-bsPM2zDzNuof7-axu27r-0c_11_BxxnY4uwm1FJdLI9OU6KJpNW93bt1mVL-l1MATlotav5-nwebjP2V64ybnxQIA1CU1YbZHxP0pNY</recordid><startdate>20071102</startdate><enddate>20071102</enddate><creator>Aravin, Alexei A</creator><creator>Hannon, Gregory J</creator><creator>Brennecke, Julius</creator><general>American Association for the Advancement of Science</general><general>The American Association for the Advancement of Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TK</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20071102</creationdate><title>Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race</title><author>Aravin, Alexei A ; Hannon, Gregory J ; Brennecke, Julius</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c525t-160fbf6b7886cfa064c2c3a5f71dd825f5f6edc896cf79b4b5af136a902b127c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adaptation, Biological</topic><topic>Animals</topic><topic>Argonaute Proteins</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>DNA Transposable Elements</topic><topic>Drosophila</topic><topic>Drosophila Proteins</topic><topic>Evolution, Molecular</topic><topic>Evolutionary biology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Silencing</topic><topic>Genetic loci</topic><topic>Genic rearrangement. Recombination. Transposable element</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Germ cells</topic><topic>Mammals</topic><topic>MicroRNA</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Pachytene stage</topic><topic>Proteins</topic><topic>Proteins - genetics</topic><topic>Proteins - physiology</topic><topic>Review</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA, Small Interfering</topic><topic>RNA-Binding Proteins - genetics</topic><topic>RNA-Binding Proteins - physiology</topic><topic>RNA-Induced Silencing Complex</topic><topic>Small interfering RNA</topic><topic>Transposons</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aravin, Alexei A</creatorcontrib><creatorcontrib>Hannon, Gregory J</creatorcontrib><creatorcontrib>Brennecke, Julius</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aravin, Alexei A</au><au>Hannon, Gregory J</au><au>Brennecke, Julius</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2007-11-02</date><risdate>2007</risdate><volume>318</volume><issue>5851</issue><spage>761</spage><epage>764</epage><pages>761-764</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways to regulate gene expression, to mediate antiviral responses, to organize chromosomal domains, and to restrain the spread of selfish genetic elements. 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| ispartof | Science (American Association for the Advancement of Science), 2007-11, Vol.318 (5851), p.761-764 |
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| subjects | Adaptation, Biological Animals Argonaute Proteins Base Sequence Biological and medical sciences DNA Transposable Elements Drosophila Drosophila Proteins Evolution, Molecular Evolutionary biology Fundamental and applied biological sciences. Psychology Gene expression Gene Silencing Genetic loci Genic rearrangement. Recombination. Transposable element Genomes Genomics Germ cells Mammals MicroRNA Molecular and cellular biology Molecular genetics Molecular Sequence Data Pachytene stage Proteins Proteins - genetics Proteins - physiology Review Ribonucleic acid RNA RNA, Small Interfering RNA-Binding Proteins - genetics RNA-Binding Proteins - physiology RNA-Induced Silencing Complex Small interfering RNA Transposons |
| title | Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race |
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