Oral sustained delivery of atenolol from floating matrix tablets : Formulation and in vitro evaluation

Floating matrix tablets of atenolol were developed to prolong gastric residence time and increase drug bioavailability. Atenolol was chosen as a model drug because it is poorly absorbed from the lower gastrointestinal tract. The tablets were prepared by direct compression technique, using polymers s...

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Veröffentlicht in:	Drug development and industrial pharmacy 2005-05, Vol.31 (4-5), p.367-374
Hauptverfasser:	SRIVASTAVA, A. K, WADHWA, Saurabh, RIDHURKAR, D, MISHRA, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adrenergic beta-Antagonists - chemistry Adrenergic beta-Antagonists - pharmacokinetics Atenolol - administration & dosage Atenolol - chemistry Atenolol - pharmacokinetics Biological and medical sciences Carboxymethylcellulose Sodium - chemistry Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics General pharmacology Hardness Hypromellose Derivatives Medical sciences Methylcellulose - analogs & derivatives Methylcellulose - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Porosity Surface Tension Tablets Technology, Pharmaceutical - methods
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