Formation of a Long-Lived Photoproduct with a Deprotonated Schiff Base in Proteorhodopsin, and Its Enhancement by Mutation of Asp227

Proteorhodopsin, a retinal protein of marine proteobacteria similar to bacteriorhodopsin of the archaea, is a light-driven proton pump. Absorption of a light quantum initiates a reaction cycle (turnover time of ca. 50 ms), which includes photoisomerization of the retinal from the all-trans to the 13...

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Veröffentlicht in:	Biochemistry (Easton) 2005-08, Vol.44 (32), p.10828-10838
Hauptverfasser:	Imasheva, Eleonora S, Shimono, Kazumi, Balashov, Sergei P, Wang, Jennifer M, Zadok, Uri, Sheves, Mordechai, Kamo, Naoki, Lanyi, Janos K
Format:	Artikel
Sprache:	eng
Schlagworte:	Archaea Aspartic Acid - genetics Half-Life Hydrogen-Ion Concentration Mutation, Missense Photochemistry Photons Proteobacteria Rhodopsin - chemistry Rhodopsin - genetics Rhodopsins, Microbial Schiff Bases - chemistry Ultraviolet Rays
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