Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma
AIB1, a member of the steroid receptor coactivator 1 family, has been cloned on 20q12 and is a candidate oncogene in human breast cancer. It is commonly amplified and overexpressed in several types of human cancers. In this study, we examined the expression of AIB1, as related to clinicopathologic f...
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| Veröffentlicht in: | Human pathology 2005-07, Vol.36 (7), p.777-783 |
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| creator | Xie, Dan Sham, Jonathan S.T. Zeng, Wei-Fen Lin, Han-Liang Bi, Jiong Che, Li-Hong Hu, Liang Zeng, Yi-Xin Guan, Xin-Yuan |
| description | AIB1, a member of the steroid receptor coactivator 1 family, has been cloned on 20q12 and is a candidate oncogene in human breast cancer. It is commonly amplified and overexpressed in several types of human cancers. In this study, we examined the expression of
AIB1, as related to clinicopathologic features, in 85 human colorectal cancers (CRCs). The status of the number of
AIB1 copies,
p53 expression, and DNA ploidy was also analyzed. The overexpression of
AIB1 was detected in 35% of CRCs. Amplification of
AIB1 was observed in 10% of CRCs. In addition, the overexpression of
AIB1 was observed more frequently in CRCs in later clinical stages (T3 N1 M0/T3 N0 2M1), compared with that in T3 N0 M0 stage (
P < .05). These results suggest that overexpression of
AIB1 might provide a selective advantage for the developmental growth and/or progression of subsets of CRCs. In addition, a significant correlation (
P < .05) of overexpression of
AIB1 with
p53 overexpression as well as with aneuploid DNA content was observed in these CRCs. The overexpression of
p53 was also correlated significantly with CRC DNA ploidy (
P < .05). Furthermore, there was a substantial population of CRCs showing overexpression of both AIB1 and p53 protein and all had aneuploid DNA content; most of these were in the later clinical stage. These findings suggest a possible convergence of
AIB1 with a pathway involving
p53, which might induce chromosomal instability and affect the clinical phenotype of a subset of CRCs. |
| doi_str_mv | 10.1016/j.humpath.2005.05.007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68461803</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0046817705002467</els_id><sourcerecordid>2743507051</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-1d897c2e16dd901c38cdf90126f0a4ff87d01a455a960529b7ce7f43a18ab8573</originalsourceid><addsrcrecordid>eNqFkE2LFDEQhoMo7rj6E5QG0VuPle589Ul2Bz8WFrzoUUImqXYydHfGpHvUf2_CNCx4EQqqSJ4qXh5CXlLYUqDi3XF7WMaTmQ_bBoBvS4F8RDaUt02t2q55TDYATNSKSnlFnqV0BKCUM_6UXFEBinVMbsj3XYgRBzP7MFWhr27ubmkVzhjx9yliSuX5l58PlXFnM1l0lR385K0ZqjSbH1h2chAzVTYMIaKd84810fopjOY5edKbIeGLtV-Tbx8_fN19ru-_fLrb3dzXljV0rqlTnbQNUuFcB9S2yro-D43owbC-V9IBNYxz0wngTbeXFmXPWkOV2Ssu22vy9nL3FMPPBdOsR58sDoOZMCxJC8UEVdBm8PU_4DEsccrZNIWWKdHIVmSKXygbQ0oRe32KfjTxT4Z0sa-PerWvi31dCkqMV-v1ZT-ie9hadWfgzQqYlBX2MSv16YGTwDvoVObeXzjM0s4eo07WY9Hvi2Ltgv9PlL-gpaVY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1034862736</pqid></control><display><type>article</type><title>Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Xie, Dan ; Sham, Jonathan S.T. ; Zeng, Wei-Fen ; Lin, Han-Liang ; Bi, Jiong ; Che, Li-Hong ; Hu, Liang ; Zeng, Yi-Xin ; Guan, Xin-Yuan</creator><creatorcontrib>Xie, Dan ; Sham, Jonathan S.T. ; Zeng, Wei-Fen ; Lin, Han-Liang ; Bi, Jiong ; Che, Li-Hong ; Hu, Liang ; Zeng, Yi-Xin ; Guan, Xin-Yuan</creatorcontrib><description>AIB1, a member of the steroid receptor coactivator 1 family, has been cloned on 20q12 and is a candidate oncogene in human breast cancer. It is commonly amplified and overexpressed in several types of human cancers. In this study, we examined the expression of
AIB1, as related to clinicopathologic features, in 85 human colorectal cancers (CRCs). The status of the number of
AIB1 copies,
p53 expression, and DNA ploidy was also analyzed. The overexpression of
AIB1 was detected in 35% of CRCs. Amplification of
AIB1 was observed in 10% of CRCs. In addition, the overexpression of
AIB1 was observed more frequently in CRCs in later clinical stages (T3 N1 M0/T3 N0 2M1), compared with that in T3 N0 M0 stage (
P < .05). These results suggest that overexpression of
AIB1 might provide a selective advantage for the developmental growth and/or progression of subsets of CRCs. In addition, a significant correlation (
P < .05) of overexpression of
AIB1 with
p53 overexpression as well as with aneuploid DNA content was observed in these CRCs. The overexpression of
p53 was also correlated significantly with CRC DNA ploidy (
P < .05). Furthermore, there was a substantial population of CRCs showing overexpression of both AIB1 and p53 protein and all had aneuploid DNA content; most of these were in the later clinical stage. These findings suggest a possible convergence of
AIB1 with a pathway involving
p53, which might induce chromosomal instability and affect the clinical phenotype of a subset of CRCs.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2005.05.007</identifier><identifier>PMID: 16084947</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acetyltransferases - metabolism ; Adenocarcinoma - genetics ; Adenocarcinoma - metabolism ; Adenocarcinoma - secondary ; Adult ; Aged ; Aged, 80 and over ; AIB1 ; Amplification ; Aneuploidy ; Biological and medical sciences ; Breast cancer ; Cell adhesion & migration ; Cell Nucleus - metabolism ; Cell Nucleus - pathology ; Chromosome instability ; Colorectal carcinoma ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; DNA, Neoplasm - analysis ; Female ; Flow Cytometry ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene Amplification ; Histone Acetyltransferases ; Humans ; Immunoenzyme Techniques ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Investigative techniques, diagnostic techniques (general aspects) ; Lymph Nodes - metabolism ; Lymph Nodes - pathology ; Lymphatic Metastasis - pathology ; Male ; Medical sciences ; Middle Aged ; Nuclear Receptor Coactivator 3 ; Oncogene Proteins - metabolism ; p53 ; Pathogenesis ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Protein Array Analysis ; Proteins ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tissue microarray ; Trans-Activators - metabolism ; Tumor Suppressor Protein p53 - metabolism ; Tumors</subject><ispartof>Human pathology, 2005-07, Vol.36 (7), p.777-783</ispartof><rights>2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jul 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-1d897c2e16dd901c38cdf90126f0a4ff87d01a455a960529b7ce7f43a18ab8573</citedby><cites>FETCH-LOGICAL-c421t-1d897c2e16dd901c38cdf90126f0a4ff87d01a455a960529b7ce7f43a18ab8573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0046817705002467$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17059098$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16084947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xie, Dan</creatorcontrib><creatorcontrib>Sham, Jonathan S.T.</creatorcontrib><creatorcontrib>Zeng, Wei-Fen</creatorcontrib><creatorcontrib>Lin, Han-Liang</creatorcontrib><creatorcontrib>Bi, Jiong</creatorcontrib><creatorcontrib>Che, Li-Hong</creatorcontrib><creatorcontrib>Hu, Liang</creatorcontrib><creatorcontrib>Zeng, Yi-Xin</creatorcontrib><creatorcontrib>Guan, Xin-Yuan</creatorcontrib><title>Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>AIB1, a member of the steroid receptor coactivator 1 family, has been cloned on 20q12 and is a candidate oncogene in human breast cancer. It is commonly amplified and overexpressed in several types of human cancers. In this study, we examined the expression of
AIB1, as related to clinicopathologic features, in 85 human colorectal cancers (CRCs). The status of the number of
AIB1 copies,
p53 expression, and DNA ploidy was also analyzed. The overexpression of
AIB1 was detected in 35% of CRCs. Amplification of
AIB1 was observed in 10% of CRCs. In addition, the overexpression of
AIB1 was observed more frequently in CRCs in later clinical stages (T3 N1 M0/T3 N0 2M1), compared with that in T3 N0 M0 stage (
P < .05). These results suggest that overexpression of
AIB1 might provide a selective advantage for the developmental growth and/or progression of subsets of CRCs. In addition, a significant correlation (
P < .05) of overexpression of
AIB1 with
p53 overexpression as well as with aneuploid DNA content was observed in these CRCs. The overexpression of
p53 was also correlated significantly with CRC DNA ploidy (
P < .05). Furthermore, there was a substantial population of CRCs showing overexpression of both AIB1 and p53 protein and all had aneuploid DNA content; most of these were in the later clinical stage. These findings suggest a possible convergence of
AIB1 with a pathway involving
p53, which might induce chromosomal instability and affect the clinical phenotype of a subset of CRCs.</description><subject>Acetyltransferases - metabolism</subject><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - metabolism</subject><subject>Adenocarcinoma - secondary</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>AIB1</subject><subject>Amplification</subject><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Cell adhesion & migration</subject><subject>Cell Nucleus - metabolism</subject><subject>Cell Nucleus - pathology</subject><subject>Chromosome instability</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - pathology</subject><subject>DNA, Neoplasm - analysis</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gene Amplification</subject><subject>Histone Acetyltransferases</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lymph Nodes - metabolism</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nuclear Receptor Coactivator 3</subject><subject>Oncogene Proteins - metabolism</subject><subject>p53</subject><subject>Pathogenesis</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Protein Array Analysis</subject><subject>Proteins</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tissue microarray</subject><subject>Trans-Activators - metabolism</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>Tumors</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo7rj6E5QG0VuPle589Ul2Bz8WFrzoUUImqXYydHfGpHvUf2_CNCx4EQqqSJ4qXh5CXlLYUqDi3XF7WMaTmQ_bBoBvS4F8RDaUt02t2q55TDYATNSKSnlFnqV0BKCUM_6UXFEBinVMbsj3XYgRBzP7MFWhr27ubmkVzhjx9yliSuX5l58PlXFnM1l0lR385K0ZqjSbH1h2chAzVTYMIaKd84810fopjOY5edKbIeGLtV-Tbx8_fN19ru-_fLrb3dzXljV0rqlTnbQNUuFcB9S2yro-D43owbC-V9IBNYxz0wngTbeXFmXPWkOV2Ssu22vy9nL3FMPPBdOsR58sDoOZMCxJC8UEVdBm8PU_4DEsccrZNIWWKdHIVmSKXygbQ0oRe32KfjTxT4Z0sa-PerWvi31dCkqMV-v1ZT-ie9hadWfgzQqYlBX2MSv16YGTwDvoVObeXzjM0s4eo07WY9Hvi2Ltgv9PlL-gpaVY</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Xie, Dan</creator><creator>Sham, Jonathan S.T.</creator><creator>Zeng, Wei-Fen</creator><creator>Lin, Han-Liang</creator><creator>Bi, Jiong</creator><creator>Che, Li-Hong</creator><creator>Hu, Liang</creator><creator>Zeng, Yi-Xin</creator><creator>Guan, Xin-Yuan</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma</title><author>Xie, Dan ; Sham, Jonathan S.T. ; Zeng, Wei-Fen ; Lin, Han-Liang ; Bi, Jiong ; Che, Li-Hong ; Hu, Liang ; Zeng, Yi-Xin ; Guan, Xin-Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-1d897c2e16dd901c38cdf90126f0a4ff87d01a455a960529b7ce7f43a18ab8573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Acetyltransferases - metabolism</topic><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - metabolism</topic><topic>Adenocarcinoma - secondary</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>AIB1</topic><topic>Amplification</topic><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Cell adhesion & migration</topic><topic>Cell Nucleus - metabolism</topic><topic>Cell Nucleus - pathology</topic><topic>Chromosome instability</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - pathology</topic><topic>DNA, Neoplasm - analysis</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gene Amplification</topic><topic>Histone Acetyltransferases</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Lymph Nodes - metabolism</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nuclear Receptor Coactivator 3</topic><topic>Oncogene Proteins - metabolism</topic><topic>p53</topic><topic>Pathogenesis</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Protein Array Analysis</topic><topic>Proteins</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tissue microarray</topic><topic>Trans-Activators - metabolism</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Dan</creatorcontrib><creatorcontrib>Sham, Jonathan S.T.</creatorcontrib><creatorcontrib>Zeng, Wei-Fen</creatorcontrib><creatorcontrib>Lin, Han-Liang</creatorcontrib><creatorcontrib>Bi, Jiong</creatorcontrib><creatorcontrib>Che, Li-Hong</creatorcontrib><creatorcontrib>Hu, Liang</creatorcontrib><creatorcontrib>Zeng, Yi-Xin</creatorcontrib><creatorcontrib>Guan, Xin-Yuan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Dan</au><au>Sham, Jonathan S.T.</au><au>Zeng, Wei-Fen</au><au>Lin, Han-Liang</au><au>Bi, Jiong</au><au>Che, Li-Hong</au><au>Hu, Liang</au><au>Zeng, Yi-Xin</au><au>Guan, Xin-Yuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>36</volume><issue>7</issue><spage>777</spage><epage>783</epage><pages>777-783</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>AIB1, a member of the steroid receptor coactivator 1 family, has been cloned on 20q12 and is a candidate oncogene in human breast cancer. It is commonly amplified and overexpressed in several types of human cancers. In this study, we examined the expression of
AIB1, as related to clinicopathologic features, in 85 human colorectal cancers (CRCs). The status of the number of
AIB1 copies,
p53 expression, and DNA ploidy was also analyzed. The overexpression of
AIB1 was detected in 35% of CRCs. Amplification of
AIB1 was observed in 10% of CRCs. In addition, the overexpression of
AIB1 was observed more frequently in CRCs in later clinical stages (T3 N1 M0/T3 N0 2M1), compared with that in T3 N0 M0 stage (
P < .05). These results suggest that overexpression of
AIB1 might provide a selective advantage for the developmental growth and/or progression of subsets of CRCs. In addition, a significant correlation (
P < .05) of overexpression of
AIB1 with
p53 overexpression as well as with aneuploid DNA content was observed in these CRCs. The overexpression of
p53 was also correlated significantly with CRC DNA ploidy (
P < .05). Furthermore, there was a substantial population of CRCs showing overexpression of both AIB1 and p53 protein and all had aneuploid DNA content; most of these were in the later clinical stage. These findings suggest a possible convergence of
AIB1 with a pathway involving
p53, which might induce chromosomal instability and affect the clinical phenotype of a subset of CRCs.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16084947</pmid><doi>10.1016/j.humpath.2005.05.007</doi><tpages>7</tpages></addata></record> |
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| ispartof | Human pathology, 2005-07, Vol.36 (7), p.777-783 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetyltransferases - metabolism Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - secondary Adult Aged Aged, 80 and over AIB1 Amplification Aneuploidy Biological and medical sciences Breast cancer Cell adhesion & migration Cell Nucleus - metabolism Cell Nucleus - pathology Chromosome instability Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology DNA, Neoplasm - analysis Female Flow Cytometry Gastroenterology. Liver. Pancreas. Abdomen Gene Amplification Histone Acetyltransferases Humans Immunoenzyme Techniques Immunohistochemistry In Situ Hybridization, Fluorescence Investigative techniques, diagnostic techniques (general aspects) Lymph Nodes - metabolism Lymph Nodes - pathology Lymphatic Metastasis - pathology Male Medical sciences Middle Aged Nuclear Receptor Coactivator 3 Oncogene Proteins - metabolism p53 Pathogenesis Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Protein Array Analysis Proteins Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tissue microarray Trans-Activators - metabolism Tumor Suppressor Protein p53 - metabolism Tumors |
| title | Correlation of AIB1 overexpression with advanced clinical stage of human colorectal carcinoma |
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