BAG3 Regulates Motility and Adhesion of Epithelial Cancer Cells

BAG3 protein binds to and regulates Hsp70 chaperone activity. The BAG3 protein contains a WW domain and a proline-rich region with SH3-binding motifs, suggesting that it may interact with proteins relevant to signal transduction, recruiting Hsp70 to signaling complexes and altering cell responses. B...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-11, Vol.67 (21), p.10252-10259
Hauptverfasser:	IWASAKI, Masahiro, HOMMA, Sachiko, HISHIYA, Akinori, DOLEZAL, Samuel J, REED, John C, TAKAYAMA, Shinichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - analysis Adaptor Proteins, Signal Transducing - physiology Animals Antineoplastic agents Apoptosis Regulatory Proteins Biological and medical sciences Carrier Proteins - analysis Carrier Proteins - chemistry Carrier Proteins - physiology Cell Adhesion Cell Line, Tumor Cell Movement Cercopithecus aethiops COS Cells HSP70 Heat-Shock Proteins - physiology Humans Male Medical sciences Mice Neoplasm Invasiveness Neoplasm Metastasis Neoplasms, Glandular and Epithelial - pathology Pharmacology. Drug treatments rac1 GTP-Binding Protein - metabolism src Homology Domains Tumors
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