Chaperones and Proteases-Guardians of Protein Integrity in Eukaryotic Organelles
: Organelles like mitochondria, chloroplasts, or the endoplasmic reticulum are essential subcompartments of eukaryotic cells that fulfill important metabolic tasks. Organellar protein homeostasis is maintained by a combination of specific protein biogenesis processes and protein quality control (PQ...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2007-10, Vol.1113 (1), p.72-86 |
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| container_title | Annals of the New York Academy of Sciences |
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| creator | LEIDHOLD, CLAUDIA VOOS, WOLFGANG |
| description | : Organelles like mitochondria, chloroplasts, or the endoplasmic reticulum are essential subcompartments of eukaryotic cells that fulfill important metabolic tasks. Organellar protein homeostasis is maintained by a combination of specific protein biogenesis processes and protein quality control (PQC) mechanisms that together guarantee the functional state of the organelle. According to their endosymbiontic origin, mitochondria and chloroplasts contain internal PQC systems that consist of a cooperative network of molecular chaperones and proteases. In contrast, the endoplasmic reticulum employs the main cytosolic degradation machinery, the proteasome, for the removal of damaged or misfolded proteins. Here we present and discuss recent experimental insights into the molecular mechanisms underlying organellar PQC processes. |
| doi_str_mv | 10.1196/annals.1391.011 |
| format | Article |
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| subjects | Animals chaperone chloroplast endoplasmic reticulum Eukaryotic Cells - enzymology Eukaryotic Cells - metabolism Humans mitochondria Mitochondria - enzymology Mitochondria - physiology Molecular Chaperones - physiology Organelles - enzymology Organelles - physiology Peptide Hydrolases - physiology protease |
| title | Chaperones and Proteases-Guardians of Protein Integrity in Eukaryotic Organelles |
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