Rotavirus Antigenemia in Patients with Acute Gastroenteritis
Although rotavirus infections are generally considered to be confined to the intestine, recent reports suggest that extraintestinal disease occurs. We studied whether rotavirus infection was associated with antigenemia during a major outbreak of gastroenteritis in the Kingston metropolitan area, dur...
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| Veröffentlicht in: | The Journal of infectious diseases 2005-09, Vol.192 (5), p.913-919 |
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| container_title | The Journal of infectious diseases |
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| creator | Fischer, Thea K. Ashley, Deanna Kerin, Tara Reynolds-Hedmann, Erica Gentsch, Jon Widdowson, Marc-Alain Westerman, Larry Puhr, Nancy Turcios, Reina M. Glass, Roger I. |
| description | Although rotavirus infections are generally considered to be confined to the intestine, recent reports suggest that extraintestinal disease occurs. We studied whether rotavirus infection was associated with antigenemia during a major outbreak of gastroenteritis in the Kingston metropolitan area, during July–August 2003. Rotavirus antigen was identified in 30 of 70 acute-phase serum samples (including from 2 deceased individuals) but in only 1 of 53 control samples. Serum antigen levels were inversely associated with time since symptom onset and were directly associated with antigen levels in stool (P=.02). Serum antigen levels were significantly elevated during primary infections (acute-phase serum immunoglobulin G [IgG] titers, |
| doi_str_mv | 10.1086/432549 |
| format | Article |
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We studied whether rotavirus infection was associated with antigenemia during a major outbreak of gastroenteritis in the Kingston metropolitan area, during July–August 2003. Rotavirus antigen was identified in 30 of 70 acute-phase serum samples (including from 2 deceased individuals) but in only 1 of 53 control samples. Serum antigen levels were inversely associated with time since symptom onset and were directly associated with antigen levels in stool (P=.02). Serum antigen levels were significantly elevated during primary infections (acute-phase serum immunoglobulin G [IgG] titers, <25), compared with those in subsequent infections (acute-phase serum IgG titers, ⩾25) (P=.02). Antigenemia was common in this outbreak and might provide a mechanism to help explain rare but well-documented reports of findings of extraintestinal rotavirus. In situations in which stool samples are not readily available (i.e., patients with severe dehydration or those recently recovered or deceased), serum testing by enzyme immunoassay offers a new and practical diagnostic tool</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/432549</identifier><identifier>PMID: 16088842</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Antibodies, Viral - blood ; Antigens ; Antigens, Viral - blood ; Biological and medical sciences ; Child ; Child, Preschool ; Diarrhea ; Disease Outbreaks ; Feces - virology ; Female ; Fundamental and applied biological sciences. Psychology ; Gastroenteritis ; Gastroenteritis - epidemiology ; Gastroenteritis - immunology ; Gastroenteritis - virology ; Humans ; Immunoglobulin G - blood ; Infant ; Infections ; Infectious diseases ; Jamaica - epidemiology ; Male ; Medical sciences ; Microbiology ; Miscellaneous ; Optical density ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Viral - chemistry ; RNA, Viral - genetics ; Rotavirus ; Rotavirus - genetics ; Rotavirus - growth & development ; Rotavirus infections ; Rotavirus Infections - epidemiology ; Rotavirus Infections - immunology ; Rotavirus Infections - virology ; Virology ; Viruses</subject><ispartof>The Journal of infectious diseases, 2005-09, Vol.192 (5), p.913-919</ispartof><rights>Copyright 2005 Infectious Diseases Society of America</rights><rights>2005 by the Infectious Diseases Society of America 2005</rights><rights>2005 INIST-CNRS</rights><rights>Copyright University of Chicago Press Sep 1, 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-b3c05caa4c0af8553ae7c11b590b666c285b7cb855ffdcb25b94641abec90a0e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30086304$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30086304$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,781,785,804,27929,27930,58022,58255</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17118810$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16088842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fischer, Thea K.</creatorcontrib><creatorcontrib>Ashley, Deanna</creatorcontrib><creatorcontrib>Kerin, Tara</creatorcontrib><creatorcontrib>Reynolds-Hedmann, Erica</creatorcontrib><creatorcontrib>Gentsch, Jon</creatorcontrib><creatorcontrib>Widdowson, Marc-Alain</creatorcontrib><creatorcontrib>Westerman, Larry</creatorcontrib><creatorcontrib>Puhr, Nancy</creatorcontrib><creatorcontrib>Turcios, Reina M.</creatorcontrib><creatorcontrib>Glass, Roger I.</creatorcontrib><title>Rotavirus Antigenemia in Patients with Acute Gastroenteritis</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Although rotavirus infections are generally considered to be confined to the intestine, recent reports suggest that extraintestinal disease occurs. We studied whether rotavirus infection was associated with antigenemia during a major outbreak of gastroenteritis in the Kingston metropolitan area, during July–August 2003. Rotavirus antigen was identified in 30 of 70 acute-phase serum samples (including from 2 deceased individuals) but in only 1 of 53 control samples. Serum antigen levels were inversely associated with time since symptom onset and were directly associated with antigen levels in stool (P=.02). Serum antigen levels were significantly elevated during primary infections (acute-phase serum immunoglobulin G [IgG] titers, <25), compared with those in subsequent infections (acute-phase serum IgG titers, ⩾25) (P=.02). Antigenemia was common in this outbreak and might provide a mechanism to help explain rare but well-documented reports of findings of extraintestinal rotavirus. In situations in which stool samples are not readily available (i.e., patients with severe dehydration or those recently recovered or deceased), serum testing by enzyme immunoassay offers a new and practical diagnostic tool</description><subject>Antibodies, Viral - blood</subject><subject>Antigens</subject><subject>Antigens, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diarrhea</subject><subject>Disease Outbreaks</subject><subject>Feces - virology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenteritis</subject><subject>Gastroenteritis - epidemiology</subject><subject>Gastroenteritis - immunology</subject><subject>Gastroenteritis - virology</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Infant</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Jamaica - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Optical density</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Viral - chemistry</subject><subject>RNA, Viral - genetics</subject><subject>Rotavirus</subject><subject>Rotavirus - genetics</subject><subject>Rotavirus - growth & development</subject><subject>Rotavirus infections</subject><subject>Rotavirus Infections - epidemiology</subject><subject>Rotavirus Infections - immunology</subject><subject>Rotavirus Infections - virology</subject><subject>Virology</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0F1LHDEUBuBQLHW19R8oY6G9m_Zk8jngzbJYLZV-UUG8CScxo1l3Z7ZJxrb_viOzuCCIV4FzHt5wXkL2KHygoOVHzirB6xdkQgVTpZSUbZEJQFWVVNf1NtlJaQ4AnEn1imxTCVprXk3I0c8u412IfSqmbQ7XvvXLgEVoi--Yg29zKv6EfFNMXZ99cYIpx26Y-hhySK_JywYXyb9Zv7vk_NPxr9lpefbt5PNselY6rlkuLXMgHCJ3gI0WgqFXjlIrarBSSldpYZWzw6ZprpythK255BStdzUgeLZL3o-5q9j97n3KZhmS84sFtr7rk5GaC61q-SykSnKtBR_g20dw3vWxHY4wVcVqkAL0Js3FLqXoG7OKYYnxn6Fg7ls3Y-sDPFin9XbprzZsXfMA3q0BJoeLJmLrQto4RanWFAZ3OLquXz392f5o5il38UExGAyD-9PKcR9S9n8f9hhvjVRMCXN6cWl-zGZfvmqpjGL_AdIAqpU</recordid><startdate>20050901</startdate><enddate>20050901</enddate><creator>Fischer, Thea K.</creator><creator>Ashley, Deanna</creator><creator>Kerin, Tara</creator><creator>Reynolds-Hedmann, Erica</creator><creator>Gentsch, Jon</creator><creator>Widdowson, Marc-Alain</creator><creator>Westerman, Larry</creator><creator>Puhr, Nancy</creator><creator>Turcios, Reina M.</creator><creator>Glass, Roger I.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050901</creationdate><title>Rotavirus Antigenemia in Patients with Acute Gastroenteritis</title><author>Fischer, Thea K. ; Ashley, Deanna ; Kerin, Tara ; Reynolds-Hedmann, Erica ; Gentsch, Jon ; Widdowson, Marc-Alain ; Westerman, Larry ; Puhr, Nancy ; Turcios, Reina M. ; Glass, Roger I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-b3c05caa4c0af8553ae7c11b590b666c285b7cb855ffdcb25b94641abec90a0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Antibodies, Viral - blood</topic><topic>Antigens</topic><topic>Antigens, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diarrhea</topic><topic>Disease Outbreaks</topic><topic>Feces - virology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenteritis</topic><topic>Gastroenteritis - epidemiology</topic><topic>Gastroenteritis - immunology</topic><topic>Gastroenteritis - virology</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Infant</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Jamaica - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Optical density</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Viral - chemistry</topic><topic>RNA, Viral - genetics</topic><topic>Rotavirus</topic><topic>Rotavirus - genetics</topic><topic>Rotavirus - growth & development</topic><topic>Rotavirus infections</topic><topic>Rotavirus Infections - epidemiology</topic><topic>Rotavirus Infections - immunology</topic><topic>Rotavirus Infections - virology</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fischer, Thea K.</creatorcontrib><creatorcontrib>Ashley, Deanna</creatorcontrib><creatorcontrib>Kerin, Tara</creatorcontrib><creatorcontrib>Reynolds-Hedmann, Erica</creatorcontrib><creatorcontrib>Gentsch, Jon</creatorcontrib><creatorcontrib>Widdowson, Marc-Alain</creatorcontrib><creatorcontrib>Westerman, Larry</creatorcontrib><creatorcontrib>Puhr, Nancy</creatorcontrib><creatorcontrib>Turcios, Reina M.</creatorcontrib><creatorcontrib>Glass, Roger I.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fischer, Thea K.</au><au>Ashley, Deanna</au><au>Kerin, Tara</au><au>Reynolds-Hedmann, Erica</au><au>Gentsch, Jon</au><au>Widdowson, Marc-Alain</au><au>Westerman, Larry</au><au>Puhr, Nancy</au><au>Turcios, Reina M.</au><au>Glass, Roger I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rotavirus Antigenemia in Patients with Acute Gastroenteritis</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2005-09-01</date><risdate>2005</risdate><volume>192</volume><issue>5</issue><spage>913</spage><epage>919</epage><pages>913-919</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Although rotavirus infections are generally considered to be confined to the intestine, recent reports suggest that extraintestinal disease occurs. We studied whether rotavirus infection was associated with antigenemia during a major outbreak of gastroenteritis in the Kingston metropolitan area, during July–August 2003. Rotavirus antigen was identified in 30 of 70 acute-phase serum samples (including from 2 deceased individuals) but in only 1 of 53 control samples. Serum antigen levels were inversely associated with time since symptom onset and were directly associated with antigen levels in stool (P=.02). Serum antigen levels were significantly elevated during primary infections (acute-phase serum immunoglobulin G [IgG] titers, <25), compared with those in subsequent infections (acute-phase serum IgG titers, ⩾25) (P=.02). Antigenemia was common in this outbreak and might provide a mechanism to help explain rare but well-documented reports of findings of extraintestinal rotavirus. In situations in which stool samples are not readily available (i.e., patients with severe dehydration or those recently recovered or deceased), serum testing by enzyme immunoassay offers a new and practical diagnostic tool</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>16088842</pmid><doi>10.1086/432549</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antibodies, Viral - blood Antigens Antigens, Viral - blood Biological and medical sciences Child Child, Preschool Diarrhea Disease Outbreaks Feces - virology Female Fundamental and applied biological sciences. Psychology Gastroenteritis Gastroenteritis - epidemiology Gastroenteritis - immunology Gastroenteritis - virology Humans Immunoglobulin G - blood Infant Infections Infectious diseases Jamaica - epidemiology Male Medical sciences Microbiology Miscellaneous Optical density Reverse Transcriptase Polymerase Chain Reaction RNA, Viral - chemistry RNA, Viral - genetics Rotavirus Rotavirus - genetics Rotavirus - growth & development Rotavirus infections Rotavirus Infections - epidemiology Rotavirus Infections - immunology Rotavirus Infections - virology Virology Viruses |
| title | Rotavirus Antigenemia in Patients with Acute Gastroenteritis |
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