Differences among cell types in NAD+ compartmentalization: A comparison of neurons, astrocytes, and cardiac myocytes

Activation of the nuclear enzyme poly(ADP‐ribose)‐1 leads to the death of neurons and other types of cells by a mechanism involving NAD+ depletion and mitochondrial permeability transition. It has been proposed that the mitochondrial permeability transition (MPT) is required for NAD+ to be released...

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Veröffentlicht in:	Journal of neuroscience research 2007-11, Vol.85 (15), p.3378-3385
Hauptverfasser:	Alano, Conrad C., Tran, Alexandra, Tao, Rong, Ying, Weihai, Karliner, Joel S., Swanson, Raymond A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - chemistry Astrocytes - drug effects Astrocytes - metabolism Blotting, Western Cell Death - physiology Cells, Cultured cyclosporin A Cyclosporine - pharmacology Cytosol - chemistry Enzyme Activation - physiology Male Methylnitronitrosoguanidine - pharmacology Mice mitochondria Myocytes, Cardiac - chemistry Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism NAD - drug effects NAD - metabolism Neurons - chemistry Neurons - drug effects Neurons - metabolism Poly (ADP-Ribose) Polymerase-1 poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerases - metabolism Rats Rats, Sprague-Dawley
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