Apoptosis in the kidneys of patients with type II diabetic nephropathy
The occurrence and extent of apoptosis in the kidneys of patients with diabetic nephropathy is largely unknown. We evaluated apoptosis in renal biopsies obtained from patients with early or advanced type II diabetic nephropathy. Apoptosis was about 6- and 3-fold higher, respectively, in glomeruli an...
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| Veröffentlicht in: | Kidney international 2007-11, Vol.72 (10), p.1262-1272 |
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| creator | Verzola, D. Gandolfo, M.T. Ferrario, F. Rastaldi, M.P. Villaggio, B. Gianiorio, F. Giannoni, M. Rimoldi, L. Lauria, F. Miji, M. Deferrari, G. Garibotto, G. |
| description | The occurrence and extent of apoptosis in the kidneys of patients with diabetic nephropathy is largely unknown. We evaluated apoptosis in renal biopsies obtained from patients with early or advanced type II diabetic nephropathy. Apoptosis was about 6- and 3-fold higher, respectively, in glomeruli and tubules in kidneys of patients with early nephropathy than in the normal kidney and this was not further increased in advanced diabetic nephropathy. Glomerular apoptosis was related directly to hemoglobin A1c and systolic blood pressure, whereas tubular cell apoptosis correlated to diabetes duration and low-density lipoprotein-cholesterol. Fas, Fas ligand, and p38 mitogen-activated protein kinase expressions were enhanced in glomeruli and tubules; however, this did not correlate with apoptosis. In patients with proteinuria, apoptosis was associated with the subsequent loss of kidney function. When these parameters were subjected to multivariate analysis, only glomerular apoptosis retained a significant independent predictive value. Our findings suggest that apoptosis might be a clinically relevant mechanism of glomerular and tubular cell loss in proteinuric type II diabetic patients. |
| doi_str_mv | 10.1038/sj.ki.5002531 |
| format | Article |
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We evaluated apoptosis in renal biopsies obtained from patients with early or advanced type II diabetic nephropathy. Apoptosis was about 6- and 3-fold higher, respectively, in glomeruli and tubules in kidneys of patients with early nephropathy than in the normal kidney and this was not further increased in advanced diabetic nephropathy. Glomerular apoptosis was related directly to hemoglobin A1c and systolic blood pressure, whereas tubular cell apoptosis correlated to diabetes duration and low-density lipoprotein-cholesterol. Fas, Fas ligand, and p38 mitogen-activated protein kinase expressions were enhanced in glomeruli and tubules; however, this did not correlate with apoptosis. In patients with proteinuria, apoptosis was associated with the subsequent loss of kidney function. When these parameters were subjected to multivariate analysis, only glomerular apoptosis retained a significant independent predictive value. Our findings suggest that apoptosis might be a clinically relevant mechanism of glomerular and tubular cell loss in proteinuric type II diabetic patients.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1038/sj.ki.5002531</identifier><identifier>PMID: 17851466</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>anti-ssDNA ; apoptosis ; Apoptosis - physiology ; Biological and medical sciences ; Biopsy ; Case-Control Studies ; Cholesterol, LDL - blood ; diabetes mellitus ; Diabetes Mellitus, Type 2 - pathology ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Diabetic Nephropathies - pathology ; Diabetic Nephropathies - physiopathology ; diabetic nephropathy ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fas ; Fas Ligand Protein - metabolism ; fas Receptor - metabolism ; Glomerular Filtration Rate ; Glycated Hemoglobin A - analysis ; Humans ; Immunohistochemistry ; Kidney - pathology ; Kidney - surgery ; Kidney Glomerulus - metabolism ; Kidney Tubules - blood supply ; Kidneys ; Medical sciences ; Multivariate Analysis ; Nephrology. Urinary tract diseases ; p38 MAPK ; p38 Mitogen-Activated Protein Kinases - metabolism ; Up-Regulation ; Urinary system involvement in other diseases. Miscellaneous</subject><ispartof>Kidney international, 2007-11, Vol.72 (10), p.1262-1272</ispartof><rights>2007 International Society of Nephrology</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-3c78829d905e01c39675819b57bf3d4168dc99b30dc0ff1bbacafc77936acbb03</citedby><cites>FETCH-LOGICAL-c408t-3c78829d905e01c39675819b57bf3d4168dc99b30dc0ff1bbacafc77936acbb03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19229675$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17851466$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verzola, D.</creatorcontrib><creatorcontrib>Gandolfo, M.T.</creatorcontrib><creatorcontrib>Ferrario, F.</creatorcontrib><creatorcontrib>Rastaldi, M.P.</creatorcontrib><creatorcontrib>Villaggio, B.</creatorcontrib><creatorcontrib>Gianiorio, F.</creatorcontrib><creatorcontrib>Giannoni, M.</creatorcontrib><creatorcontrib>Rimoldi, L.</creatorcontrib><creatorcontrib>Lauria, F.</creatorcontrib><creatorcontrib>Miji, M.</creatorcontrib><creatorcontrib>Deferrari, G.</creatorcontrib><creatorcontrib>Garibotto, G.</creatorcontrib><title>Apoptosis in the kidneys of patients with type II diabetic nephropathy</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>The occurrence and extent of apoptosis in the kidneys of patients with diabetic nephropathy is largely unknown. We evaluated apoptosis in renal biopsies obtained from patients with early or advanced type II diabetic nephropathy. Apoptosis was about 6- and 3-fold higher, respectively, in glomeruli and tubules in kidneys of patients with early nephropathy than in the normal kidney and this was not further increased in advanced diabetic nephropathy. Glomerular apoptosis was related directly to hemoglobin A1c and systolic blood pressure, whereas tubular cell apoptosis correlated to diabetes duration and low-density lipoprotein-cholesterol. Fas, Fas ligand, and p38 mitogen-activated protein kinase expressions were enhanced in glomeruli and tubules; however, this did not correlate with apoptosis. In patients with proteinuria, apoptosis was associated with the subsequent loss of kidney function. When these parameters were subjected to multivariate analysis, only glomerular apoptosis retained a significant independent predictive value. Our findings suggest that apoptosis might be a clinically relevant mechanism of glomerular and tubular cell loss in proteinuric type II diabetic patients.</description><subject>anti-ssDNA</subject><subject>apoptosis</subject><subject>Apoptosis - physiology</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Case-Control Studies</subject><subject>Cholesterol, LDL - blood</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - pathology</subject><subject>Diabetes Mellitus, Type 2 - physiopathology</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Nephropathies - pathology</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>diabetic nephropathy</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Fas</subject><subject>Fas Ligand Protein - metabolism</subject><subject>fas Receptor - metabolism</subject><subject>Glomerular Filtration Rate</subject><subject>Glycated Hemoglobin A - analysis</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kidney - pathology</subject><subject>Kidney - surgery</subject><subject>Kidney Glomerulus - metabolism</subject><subject>Kidney Tubules - blood supply</subject><subject>Kidneys</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Nephrology. Urinary tract diseases</subject><subject>p38 MAPK</subject><subject>p38 Mitogen-Activated Protein Kinases - metabolism</subject><subject>Up-Regulation</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M9r2zAUwHFRVtas3bHXoct2cypZkS0dQ2i3QGGX9iz045koP2xPT9nwf1-VGHraSTzx4SF9CbnnbMmZUA-4Xx7iUjJWS8GvyILLWlS8lfITWTCmZFXu1Q35grhnZdaCfSY3vFWSr5pmQZ7W4zDmASPS2NO8A3qIoYcJ6dDR0eYIfUb6L-YdzdMIdLulIVoHOXraw7hLQ0G76Y5cd_aI8HU-b8nr0-PL5lf1_PvndrN-rvyKqVwJ3ypV66CZBMa90E0rFddOtq4TYcUbFbzWTrDgWddx56y3nW9bLRrrnWPilvy47B3T8OcMmM0poofj0fYwnNE0aiWVrHWB1QX6NCAm6MyY4smmyXBm3sMZ3JtDNHO44r_Ni8_uBOFDz6UK-D4Di94eu2R7H_HD6bp-_01x7cVByfA3QjLoS0QPISbw2YQh_ucJb24miZI</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>Verzola, D.</creator><creator>Gandolfo, M.T.</creator><creator>Ferrario, F.</creator><creator>Rastaldi, M.P.</creator><creator>Villaggio, B.</creator><creator>Gianiorio, F.</creator><creator>Giannoni, M.</creator><creator>Rimoldi, L.</creator><creator>Lauria, F.</creator><creator>Miji, M.</creator><creator>Deferrari, G.</creator><creator>Garibotto, G.</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071101</creationdate><title>Apoptosis in the kidneys of patients with type II diabetic nephropathy</title><author>Verzola, D. ; Gandolfo, M.T. ; Ferrario, F. ; Rastaldi, M.P. ; Villaggio, B. ; Gianiorio, F. ; Giannoni, M. ; Rimoldi, L. ; Lauria, F. ; Miji, M. ; Deferrari, G. ; Garibotto, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-3c78829d905e01c39675819b57bf3d4168dc99b30dc0ff1bbacafc77936acbb03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>anti-ssDNA</topic><topic>apoptosis</topic><topic>Apoptosis - physiology</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Case-Control Studies</topic><topic>Cholesterol, LDL - blood</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - pathology</topic><topic>Diabetes Mellitus, Type 2 - physiopathology</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Nephropathies - pathology</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>diabetic nephropathy</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Fas</topic><topic>Fas Ligand Protein - metabolism</topic><topic>fas Receptor - metabolism</topic><topic>Glomerular Filtration Rate</topic><topic>Glycated Hemoglobin A - analysis</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kidney - pathology</topic><topic>Kidney - surgery</topic><topic>Kidney Glomerulus - metabolism</topic><topic>Kidney Tubules - blood supply</topic><topic>Kidneys</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Nephrology. Urinary tract diseases</topic><topic>p38 MAPK</topic><topic>p38 Mitogen-Activated Protein Kinases - metabolism</topic><topic>Up-Regulation</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verzola, D.</creatorcontrib><creatorcontrib>Gandolfo, M.T.</creatorcontrib><creatorcontrib>Ferrario, F.</creatorcontrib><creatorcontrib>Rastaldi, M.P.</creatorcontrib><creatorcontrib>Villaggio, B.</creatorcontrib><creatorcontrib>Gianiorio, F.</creatorcontrib><creatorcontrib>Giannoni, M.</creatorcontrib><creatorcontrib>Rimoldi, L.</creatorcontrib><creatorcontrib>Lauria, F.</creatorcontrib><creatorcontrib>Miji, M.</creatorcontrib><creatorcontrib>Deferrari, G.</creatorcontrib><creatorcontrib>Garibotto, G.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verzola, D.</au><au>Gandolfo, M.T.</au><au>Ferrario, F.</au><au>Rastaldi, M.P.</au><au>Villaggio, B.</au><au>Gianiorio, F.</au><au>Giannoni, M.</au><au>Rimoldi, L.</au><au>Lauria, F.</au><au>Miji, M.</au><au>Deferrari, G.</au><au>Garibotto, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apoptosis in the kidneys of patients with type II diabetic nephropathy</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>72</volume><issue>10</issue><spage>1262</spage><epage>1272</epage><pages>1262-1272</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>The occurrence and extent of apoptosis in the kidneys of patients with diabetic nephropathy is largely unknown. We evaluated apoptosis in renal biopsies obtained from patients with early or advanced type II diabetic nephropathy. Apoptosis was about 6- and 3-fold higher, respectively, in glomeruli and tubules in kidneys of patients with early nephropathy than in the normal kidney and this was not further increased in advanced diabetic nephropathy. Glomerular apoptosis was related directly to hemoglobin A1c and systolic blood pressure, whereas tubular cell apoptosis correlated to diabetes duration and low-density lipoprotein-cholesterol. Fas, Fas ligand, and p38 mitogen-activated protein kinase expressions were enhanced in glomeruli and tubules; however, this did not correlate with apoptosis. In patients with proteinuria, apoptosis was associated with the subsequent loss of kidney function. When these parameters were subjected to multivariate analysis, only glomerular apoptosis retained a significant independent predictive value. Our findings suggest that apoptosis might be a clinically relevant mechanism of glomerular and tubular cell loss in proteinuric type II diabetic patients.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>17851466</pmid><doi>10.1038/sj.ki.5002531</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | anti-ssDNA apoptosis Apoptosis - physiology Biological and medical sciences Biopsy Case-Control Studies Cholesterol, LDL - blood diabetes mellitus Diabetes Mellitus, Type 2 - pathology Diabetes Mellitus, Type 2 - physiopathology Diabetes. Impaired glucose tolerance Diabetic Nephropathies - pathology Diabetic Nephropathies - physiopathology diabetic nephropathy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Fas Fas Ligand Protein - metabolism fas Receptor - metabolism Glomerular Filtration Rate Glycated Hemoglobin A - analysis Humans Immunohistochemistry Kidney - pathology Kidney - surgery Kidney Glomerulus - metabolism Kidney Tubules - blood supply Kidneys Medical sciences Multivariate Analysis Nephrology. Urinary tract diseases p38 MAPK p38 Mitogen-Activated Protein Kinases - metabolism Up-Regulation Urinary system involvement in other diseases. Miscellaneous |
| title | Apoptosis in the kidneys of patients with type II diabetic nephropathy |
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