Cyclophilin A may contribute to the inflammatory processes in rheumatoid arthritis through induction of matrix degrading enzymes and inflammatory cytokines from macrophages

Cyclophilin A (CypA) levels increase in the sera and synovial fluids of rheumatoid arthritis (RA) patients, but the cell types expressing CypA and the function of CypA in the pathogenesis of RA are not known yet. Immunohistochemistry analyses revealed high level CypA staining in the macrophages in t...

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Veröffentlicht in:	Clinical Immunology 2005-09, Vol.116 (3), p.217-224
Hauptverfasser:	Kim, Ho, Kim, Won-Jung, Jeon, Sung-Tak, Koh, Eun-Mi, Cha, Hoon-Suk, Ahn, Kwang-Sung, Lee, Won-Ha
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Rheumatoid - enzymology Arthritis, Rheumatoid - etiology Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Biological and medical sciences Cell Line Cyclophilin A Cyclophilin A - metabolism Cyclophilin A - pharmacology Cytokines - biosynthesis Endothelium - enzymology Endothelium - immunology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immunopathology Inflammation Mediators - metabolism Macrophages - drug effects Macrophages - enzymology Macrophages - immunology Matrix metalloproteinase (MMP)-9 Matrix Metalloproteinase 9 - biosynthesis Medical sciences Mice Rheumatoid arthritis Synovial Membrane - enzymology Synovial Membrane - immunology
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