Simultaneous analysis of dextromethorphan and its three metabolites in human plasma using an improved HPLC method with fluorometric detection

A simple and improved HPLC method with fluorometric detection for simultaneous determination of dextromethorphan (DM) and its three metabolites (dextrorphan (DX), 3-methoxymorphinan (MM), 3-hydroxymorphinan (HM)) in human plasma was developed and validated. The method involved a simple and efficient...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2007-11, Vol.859 (1), p.141-146
Hauptverfasser:	Lin, Shyr-Yi, Chen, Chien-Ho, Ho, Hsiu-O, Chen, Hsueh-Hui, Sheu, Ming-Thau
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Chromatography, High Pressure Liquid - instrumentation Chromatography, High Pressure Liquid - methods Dextromethorphan Dextromethorphan - administration & dosage Dextromethorphan - analogs & derivatives Dextromethorphan - blood Dextrorphan Dextrorphan - blood Fundamental and applied biological sciences. Psychology General pharmacology Humans Hydroxymorphinan Medical sciences Methoxymorphinan Pharmacology. Drug treatments Phenyl column Reproducibility of Results Sensitivity and Specificity Spectrometry, Fluorescence Time Factors
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