A HPLC method for the simultaneous determination of seven anthracyclines

A HPLC method has been developed for the determination of epirubicin hydrochloride, doxorubicin hydrochloride and idarubicin hydrochloride in the presence of four other anthracyclines. This method ensures the rapid determination of seven anthracyclines. It is simple and rapid and does not require an...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2005-09, Vol.39 (1), p.305-309
Hauptverfasser:	Badea, Irinel, Lazăr, Lelia, Moja, Dana, Nicolescu, Daniela, Tudose, Aurel
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Anthracyclines Anthracyclines - analysis Biological and medical sciences Chromatography, High Pressure Liquid - methods Doxorubicin hydrochloride Epirubicin hydrochloride Fundamental and applied biological sciences. Psychology General pharmacology HPLC Idarubicin hydrochloride Medical sciences Pharmaceutical Preparations - chemistry Pharmacology. Drug treatments Reproducibility of Results
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Beschreibung
Zusammenfassung:	A HPLC method has been developed for the determination of epirubicin hydrochloride, doxorubicin hydrochloride and idarubicin hydrochloride in the presence of four other anthracyclines. This method ensures the rapid determination of seven anthracyclines. It is simple and rapid and does not require any preliminary treatment of the sample. The method was fully validated.
ISSN:	0731-7085 1873-264X
DOI:	10.1016/j.jpba.2005.03.039