Syndecan-1 deficiency aggravates anti-glomerular basement membrane nephritis

During the heterologous phase of experimental anti-glomerular basement membrane (anti-GBM) nephritis, leukocyte influx peaks within hours, whereas albuminuria occurs within 1 day. In the subsequent autologous phase, endogenous anti-GBM IgG develops and albuminuria persists. Heparan sulfate (HS) prot...

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Veröffentlicht in:	Kidney international 2007-11, Vol.72 (10), p.1204-1215
Hauptverfasser:	Rops, A.L., Götte, M., Baselmans, M.H., van den Hoven, M.J., Steenbergen, E.J., Lensen, J.F., Wijnhoven, T.J., Cevikbas, F., van den Heuvel, L.P., van Kuppevelt, T.H., Berden, J.H., van der Vlag, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	adhesion molecule Albuminuria - immunology Albuminuria - pathology Animals Basement Membrane - immunology Basement Membrane - pathology Biological and medical sciences CD4-CD8 Ratio chemokine chemokine receptor Creatinine - blood Fluorescent Antibody Technique, Indirect Glomerulonephritis heparan sulfate Immunoglobulin G - blood Immunohistochemistry Kidney Glomerulus - immunology Kidney Glomerulus - pathology Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Nephritis - etiology Nephritis - immunology Nephritis - pathology Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Rabbits Syndecan-1 - deficiency Th1 Cells - metabolism Th2 Cells - metabolism
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