Biased use of VH5 ige-positive B cells in the nasal mucosa in allergic rhinitis

IgE antibody-producing B cells are enriched in the nasal mucosa in patients with allergic rhinitis because of local class switching to IgE. The expressed IgE VH genes also undergo somatic hypermutation in situ to generate clonal families. The antigenic driving force behind these events is unknown. T...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2005-08, Vol.116 (2), p.445-452
Hauptverfasser:	COKER, Heather A, HARRIES, Helen E, BANFIELD, Graham K, CARR, Victoria A, DURHAM, Stephen R, CHEVRETTON, Elfy, HOBBY, Paul, SUTTON, Brian J, GOULD, Hannah J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Allergies B-Lymphocytes - immunology Binding sites Biological and medical sciences Crystal structure Dermatitis Family medical history Female Food allergies Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immune system Immunoglobulin A - genetics Immunoglobulin E - chemistry Immunoglobulin E - genetics Immunoglobulin Heavy Chains - chemistry Immunoglobulin Heavy Chains - genetics Immunoglobulin Variable Region - chemistry Immunoglobulin Variable Region - genetics Immunopathology Male Medical sciences Middle Aged Mutation Nasal Mucosa - immunology Nose Patients Rhinitis, Allergic, Perennial - immunology Rhinitis, Allergic, Seasonal - immunology
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