The origin of spontaneous activity in the developing auditory system
Spontaneous activity in the developing auditory system is required for neuronal survival as well as the refinement and maintenance of tonotopic maps in the brain. However, the mechanisms responsible for initiating auditory nerve firing in the absence of sound have not been determined. Here we show t...
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| Veröffentlicht in: | Nature 2007-11, Vol.450 (7166), p.50-55 |
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| creator | TRITSCH, Nicolas X YI, Eunyoung GALE, Jonathan E GLOWATZKI, Elisabeth BERGLES, Dwight E |
| description | Spontaneous activity in the developing auditory system is required for neuronal survival as well as the refinement and maintenance of tonotopic maps in the brain. However, the mechanisms responsible for initiating auditory nerve firing in the absence of sound have not been determined. Here we show that supporting cells in the developing rat cochlea spontaneously release ATP, which causes nearby inner hair cells to depolarize and release glutamate, triggering discrete bursts of action potentials in primary auditory neurons. This endogenous, ATP-mediated signalling synchronizes the output of neighbouring inner hair cells, which may help refine tonotopic maps in the brain. Spontaneous ATP-dependent signalling rapidly subsides after the onset of hearing, thereby preventing this experience-independent activity from interfering with accurate encoding of sound. These data indicate that supporting cells in the organ of Corti initiate electrical activity in auditory nerves before hearing, pointing to an essential role for peripheral, non-sensory cells in the development of central auditory pathways. |
| doi_str_mv | 10.1038/nature06233 |
| format | Article |
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However, the mechanisms responsible for initiating auditory nerve firing in the absence of sound have not been determined. Here we show that supporting cells in the developing rat cochlea spontaneously release ATP, which causes nearby inner hair cells to depolarize and release glutamate, triggering discrete bursts of action potentials in primary auditory neurons. This endogenous, ATP-mediated signalling synchronizes the output of neighbouring inner hair cells, which may help refine tonotopic maps in the brain. Spontaneous ATP-dependent signalling rapidly subsides after the onset of hearing, thereby preventing this experience-independent activity from interfering with accurate encoding of sound. These data indicate that supporting cells in the organ of Corti initiate electrical activity in auditory nerves before hearing, pointing to an essential role for peripheral, non-sensory cells in the development of central auditory pathways.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>EISSN: 1476-4679</identifier><identifier>DOI: 10.1038/nature06233</identifier><identifier>PMID: 17972875</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Action Potentials - drug effects ; Adenosine triphosphatase ; Adenosine Triphosphate - metabolism ; Adenosine Triphosphate - pharmacology ; Animals ; ATP ; Audiology ; Auditory Pathways - drug effects ; Auditory Pathways - growth & development ; Auditory Pathways - physiology ; Auditory Perception - drug effects ; Auditory Perception - physiology ; Biological and medical sciences ; Calcium - metabolism ; Cell Shape - drug effects ; Cellular biology ; Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation ; Ears & hearing ; Fundamental and applied biological sciences. Psychology ; Hair ; Hair Cells, Auditory - drug effects ; Hair Cells, Auditory - metabolism ; Hair Cells, Auditory - physiology ; Hearing - drug effects ; Hearing - physiology ; Rats ; Rats, Sprague-Dawley ; Rodents ; Signal transduction ; Time Factors ; Vertebrates: nervous system and sense organs</subject><ispartof>Nature, 2007-11, Vol.450 (7166), p.50-55</ispartof><rights>2007 INIST-CNRS</rights><rights>COPYRIGHT 2007 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Nov 1, 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c717t-28ad947217a4a2b05e223fd90f820da5015e61122044e5e5de04512e0385f2c13</citedby><cites>FETCH-LOGICAL-c717t-28ad947217a4a2b05e223fd90f820da5015e61122044e5e5de04512e0385f2c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19187532$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17972875$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TRITSCH, Nicolas X</creatorcontrib><creatorcontrib>YI, Eunyoung</creatorcontrib><creatorcontrib>GALE, Jonathan E</creatorcontrib><creatorcontrib>GLOWATZKI, Elisabeth</creatorcontrib><creatorcontrib>BERGLES, Dwight E</creatorcontrib><title>The origin of spontaneous activity in the developing auditory system</title><title>Nature</title><addtitle>Nature</addtitle><description>Spontaneous activity in the developing auditory system is required for neuronal survival as well as the refinement and maintenance of tonotopic maps in the brain. 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These data indicate that supporting cells in the organ of Corti initiate electrical activity in auditory nerves before hearing, pointing to an essential role for peripheral, non-sensory cells in the development of central auditory pathways.</description><subject>Action Potentials - drug effects</subject><subject>Adenosine triphosphatase</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Adenosine Triphosphate - pharmacology</subject><subject>Animals</subject><subject>ATP</subject><subject>Audiology</subject><subject>Auditory Pathways - drug effects</subject><subject>Auditory Pathways - growth & development</subject><subject>Auditory Pathways - physiology</subject><subject>Auditory Perception - drug effects</subject><subject>Auditory Perception - physiology</subject><subject>Biological and medical sciences</subject><subject>Calcium - metabolism</subject><subject>Cell Shape - drug effects</subject><subject>Cellular biology</subject><subject>Ear and associated structures. 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Academic</collection><jtitle>Nature</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TRITSCH, Nicolas X</au><au>YI, Eunyoung</au><au>GALE, Jonathan E</au><au>GLOWATZKI, Elisabeth</au><au>BERGLES, Dwight E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The origin of spontaneous activity in the developing auditory system</atitle><jtitle>Nature</jtitle><addtitle>Nature</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>450</volume><issue>7166</issue><spage>50</spage><epage>55</epage><pages>50-55</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><eissn>1476-4679</eissn><coden>NATUAS</coden><abstract>Spontaneous activity in the developing auditory system is required for neuronal survival as well as the refinement and maintenance of tonotopic maps in the brain. However, the mechanisms responsible for initiating auditory nerve firing in the absence of sound have not been determined. Here we show that supporting cells in the developing rat cochlea spontaneously release ATP, which causes nearby inner hair cells to depolarize and release glutamate, triggering discrete bursts of action potentials in primary auditory neurons. This endogenous, ATP-mediated signalling synchronizes the output of neighbouring inner hair cells, which may help refine tonotopic maps in the brain. Spontaneous ATP-dependent signalling rapidly subsides after the onset of hearing, thereby preventing this experience-independent activity from interfering with accurate encoding of sound. These data indicate that supporting cells in the organ of Corti initiate electrical activity in auditory nerves before hearing, pointing to an essential role for peripheral, non-sensory cells in the development of central auditory pathways.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>17972875</pmid><doi>10.1038/nature06233</doi><tpages>6</tpages></addata></record> |
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| subjects | Action Potentials - drug effects Adenosine triphosphatase Adenosine Triphosphate - metabolism Adenosine Triphosphate - pharmacology Animals ATP Audiology Auditory Pathways - drug effects Auditory Pathways - growth & development Auditory Pathways - physiology Auditory Perception - drug effects Auditory Perception - physiology Biological and medical sciences Calcium - metabolism Cell Shape - drug effects Cellular biology Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Ears & hearing Fundamental and applied biological sciences. Psychology Hair Hair Cells, Auditory - drug effects Hair Cells, Auditory - metabolism Hair Cells, Auditory - physiology Hearing - drug effects Hearing - physiology Rats Rats, Sprague-Dawley Rodents Signal transduction Time Factors Vertebrates: nervous system and sense organs |
| title | The origin of spontaneous activity in the developing auditory system |
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