Antineoplastic Activity of a Series of Ferrocene-containing Alcohols
Background: Often potentially good chemotherapeutic drugs find limited clinical use due to the many negative medical and physical side-effects they may exhibit. To combat these negative side-effects, new antineoplastic materials are continuously being synthesised and evaluated. Ferrocene-containing...
Gespeichert in:
| Veröffentlicht in: | Anticancer research 2007-09, Vol.27 (5A), p.3431-3433 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3433 |
|---|---|
| container_issue | 5A |
| container_start_page | 3431 |
| container_title | Anticancer research |
| container_volume | 27 |
| creator | SHAGO, Rebotsamang F SWARTS, Jannie C KREFT, Elke VAN RENSBURG, Constance E. J |
| description | Background: Often potentially good chemotherapeutic drugs find limited clinical use due to the many negative medical and physical
side-effects they may exhibit. To combat these negative side-effects, new antineoplastic materials are continuously being
synthesised and evaluated. Ferrocene-containing compounds under certain conditions may show appreciable anticancer activity.
Some of the factors that determine this activity have been investigated. Materials and Methods: Ferrocene-containing alcohols
were tested for cytotoxicity against the HeLa cancer cell line. Cell survival was measured by means of the colorometric 3-(4,5-dimethylthiazol-2-yl)-diphenyltetrazolium
bromide assay. Results: The 50% lethal dosage of 4-ferrocenylbutanol was 5.72 μmol. dm -3 and for 2-ferrocenylethanol and 3-ferrocenylpropanol it was 35.0 and 17 μmol. dm -3 respectively while for ferrocenylmethanol IC 50 was >100 μmol. dm -3 . Conclusion: A drug activity-structural relationship exists in that ferrocenyl drugs with longer side chains are more cytotoxic.
Compounds with lower ferrocenyl group formal reduction potential are also more cytotoxic. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68454531</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68454531</sourcerecordid><originalsourceid>FETCH-LOGICAL-h270t-1f0b318750cf1d79da7672bcb5afaa227da5ac703ce060c77be22b80a9557c213</originalsourceid><addsrcrecordid>eNpFj19LwzAUxYMobk6_gvRF3wr5szTtY5lOhYEP6nO4TdM1kiYzaZV9ezOc7OlcDj_OuecMzYmoSC44w-dojinHucCYz9BVjJ8YF0VVsks0S1CyKzJHD7UbjdN-ZyGORmW1Gs23GfeZ7zLI3nQwOh7utQ7BK-10rrwbwTjjtlltle-9jdfoogMb9c1RF-hj_fi-es43r08vq3qT91TgMScdbhgpBceqI62oWhCFoI1qOHQAlIoWOCiBmdK4wEqIRlPalBgqzoWihC3Q_V_uLvivScdRDiYqbS2kBVOURbnkS84O4O0RnJpBt3IXzABhL_93J-DuCEBUYLsATpl44irC05_01Nibbf9jgpZxAGtTLJMQqJC8lmyZGn8BV_tusw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68454531</pqid></control><display><type>article</type><title>Antineoplastic Activity of a Series of Ferrocene-containing Alcohols</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>SHAGO, Rebotsamang F ; SWARTS, Jannie C ; KREFT, Elke ; VAN RENSBURG, Constance E. J</creator><creatorcontrib>SHAGO, Rebotsamang F ; SWARTS, Jannie C ; KREFT, Elke ; VAN RENSBURG, Constance E. J</creatorcontrib><description>Background: Often potentially good chemotherapeutic drugs find limited clinical use due to the many negative medical and physical
side-effects they may exhibit. To combat these negative side-effects, new antineoplastic materials are continuously being
synthesised and evaluated. Ferrocene-containing compounds under certain conditions may show appreciable anticancer activity.
Some of the factors that determine this activity have been investigated. Materials and Methods: Ferrocene-containing alcohols
were tested for cytotoxicity against the HeLa cancer cell line. Cell survival was measured by means of the colorometric 3-(4,5-dimethylthiazol-2-yl)-diphenyltetrazolium
bromide assay. Results: The 50% lethal dosage of 4-ferrocenylbutanol was 5.72 μmol. dm -3 and for 2-ferrocenylethanol and 3-ferrocenylpropanol it was 35.0 and 17 μmol. dm -3 respectively while for ferrocenylmethanol IC 50 was >100 μmol. dm -3 . Conclusion: A drug activity-structural relationship exists in that ferrocenyl drugs with longer side chains are more cytotoxic.
Compounds with lower ferrocenyl group formal reduction potential are also more cytotoxic.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 17970091</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Alcohols - chemistry ; Alcohols - pharmacology ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Biological and medical sciences ; Drug Screening Assays, Antitumor ; Ferrous Compounds - chemistry ; Ferrous Compounds - pharmacology ; HeLa Cells ; Humans ; Medical sciences ; Metallocenes ; Structure-Activity Relationship ; Tumors</subject><ispartof>Anticancer research, 2007-09, Vol.27 (5A), p.3431-3433</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19158752$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17970091$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHAGO, Rebotsamang F</creatorcontrib><creatorcontrib>SWARTS, Jannie C</creatorcontrib><creatorcontrib>KREFT, Elke</creatorcontrib><creatorcontrib>VAN RENSBURG, Constance E. J</creatorcontrib><title>Antineoplastic Activity of a Series of Ferrocene-containing Alcohols</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: Often potentially good chemotherapeutic drugs find limited clinical use due to the many negative medical and physical
side-effects they may exhibit. To combat these negative side-effects, new antineoplastic materials are continuously being
synthesised and evaluated. Ferrocene-containing compounds under certain conditions may show appreciable anticancer activity.
Some of the factors that determine this activity have been investigated. Materials and Methods: Ferrocene-containing alcohols
were tested for cytotoxicity against the HeLa cancer cell line. Cell survival was measured by means of the colorometric 3-(4,5-dimethylthiazol-2-yl)-diphenyltetrazolium
bromide assay. Results: The 50% lethal dosage of 4-ferrocenylbutanol was 5.72 μmol. dm -3 and for 2-ferrocenylethanol and 3-ferrocenylpropanol it was 35.0 and 17 μmol. dm -3 respectively while for ferrocenylmethanol IC 50 was >100 μmol. dm -3 . Conclusion: A drug activity-structural relationship exists in that ferrocenyl drugs with longer side chains are more cytotoxic.
Compounds with lower ferrocenyl group formal reduction potential are also more cytotoxic.</description><subject>Alcohols - chemistry</subject><subject>Alcohols - pharmacology</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Ferrous Compounds - chemistry</subject><subject>Ferrous Compounds - pharmacology</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Metallocenes</subject><subject>Structure-Activity Relationship</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj19LwzAUxYMobk6_gvRF3wr5szTtY5lOhYEP6nO4TdM1kiYzaZV9ezOc7OlcDj_OuecMzYmoSC44w-dojinHucCYz9BVjJ8YF0VVsks0S1CyKzJHD7UbjdN-ZyGORmW1Gs23GfeZ7zLI3nQwOh7utQ7BK-10rrwbwTjjtlltle-9jdfoogMb9c1RF-hj_fi-es43r08vq3qT91TgMScdbhgpBceqI62oWhCFoI1qOHQAlIoWOCiBmdK4wEqIRlPalBgqzoWihC3Q_V_uLvivScdRDiYqbS2kBVOURbnkS84O4O0RnJpBt3IXzABhL_93J-DuCEBUYLsATpl44irC05_01Nibbf9jgpZxAGtTLJMQqJC8lmyZGn8BV_tusw</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>SHAGO, Rebotsamang F</creator><creator>SWARTS, Jannie C</creator><creator>KREFT, Elke</creator><creator>VAN RENSBURG, Constance E. J</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Antineoplastic Activity of a Series of Ferrocene-containing Alcohols</title><author>SHAGO, Rebotsamang F ; SWARTS, Jannie C ; KREFT, Elke ; VAN RENSBURG, Constance E. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h270t-1f0b318750cf1d79da7672bcb5afaa227da5ac703ce060c77be22b80a9557c213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Alcohols - chemistry</topic><topic>Alcohols - pharmacology</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Ferrous Compounds - chemistry</topic><topic>Ferrous Compounds - pharmacology</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Metallocenes</topic><topic>Structure-Activity Relationship</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHAGO, Rebotsamang F</creatorcontrib><creatorcontrib>SWARTS, Jannie C</creatorcontrib><creatorcontrib>KREFT, Elke</creatorcontrib><creatorcontrib>VAN RENSBURG, Constance E. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHAGO, Rebotsamang F</au><au>SWARTS, Jannie C</au><au>KREFT, Elke</au><au>VAN RENSBURG, Constance E. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antineoplastic Activity of a Series of Ferrocene-containing Alcohols</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>27</volume><issue>5A</issue><spage>3431</spage><epage>3433</epage><pages>3431-3433</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: Often potentially good chemotherapeutic drugs find limited clinical use due to the many negative medical and physical
side-effects they may exhibit. To combat these negative side-effects, new antineoplastic materials are continuously being
synthesised and evaluated. Ferrocene-containing compounds under certain conditions may show appreciable anticancer activity.
Some of the factors that determine this activity have been investigated. Materials and Methods: Ferrocene-containing alcohols
were tested for cytotoxicity against the HeLa cancer cell line. Cell survival was measured by means of the colorometric 3-(4,5-dimethylthiazol-2-yl)-diphenyltetrazolium
bromide assay. Results: The 50% lethal dosage of 4-ferrocenylbutanol was 5.72 μmol. dm -3 and for 2-ferrocenylethanol and 3-ferrocenylpropanol it was 35.0 and 17 μmol. dm -3 respectively while for ferrocenylmethanol IC 50 was >100 μmol. dm -3 . Conclusion: A drug activity-structural relationship exists in that ferrocenyl drugs with longer side chains are more cytotoxic.
Compounds with lower ferrocenyl group formal reduction potential are also more cytotoxic.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>17970091</pmid><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0250-7005 |
| ispartof | Anticancer research, 2007-09, Vol.27 (5A), p.3431-3433 |
| issn | 0250-7005 1791-7530 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68454531 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Alcohols - chemistry Alcohols - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Drug Screening Assays, Antitumor Ferrous Compounds - chemistry Ferrous Compounds - pharmacology HeLa Cells Humans Medical sciences Metallocenes Structure-Activity Relationship Tumors |
| title | Antineoplastic Activity of a Series of Ferrocene-containing Alcohols |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-14T07%3A52%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antineoplastic%20Activity%20of%20a%20Series%20of%20Ferrocene-containing%20Alcohols&rft.jtitle=Anticancer%20research&rft.au=SHAGO,%20Rebotsamang%20F&rft.date=2007-09-01&rft.volume=27&rft.issue=5A&rft.spage=3431&rft.epage=3433&rft.pages=3431-3433&rft.issn=0250-7005&rft.eissn=1791-7530&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E68454531%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68454531&rft_id=info:pmid/17970091&rfr_iscdi=true |