Regulation of Blood Glucose by Hypothalamic Pyruvate Metabolism
The brain keenly depends on glucose for energy, and mammalians have redundant systems to control glucose production. An increase in circulating glucose inhibits glucose production in the liver, but this negative feedback is impaired in type 2 diabetes. Here we report that a primary increase in hypot...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2005-08, Vol.309 (5736), p.943-947 |
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| creator | Lam, Tony K. T Gutierrez-Juarez, Roger Pocai, Alessandro Rossetti, Luciano |
| description | The brain keenly depends on glucose for energy, and mammalians have redundant systems to control glucose production. An increase in circulating glucose inhibits glucose production in the liver, but this negative feedback is impaired in type 2 diabetes. Here we report that a primary increase in hypothalamic glucose levels lowers blood glucose through inhibition of glucose production in rats. The effect of glucose requires its conversion to lactate followed by stimulation of pyruvate metabolism, which leads to activation of adenosine triphosphate (ATP)-sensitive potassium channels. Thus, interventions designed to enhance the hypothalamic sensing of glucose may improve glucose homeostasis in diabetes. |
| doi_str_mv | 10.1126/science.1112085 |
| format | Article |
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Thus, interventions designed to enhance the hypothalamic sensing of glucose may improve glucose homeostasis in diabetes.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1112085</identifier><identifier>PMID: 16081739</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Association for the Advancement of Science</publisher><subject>Adenosine triphosphatase ; Analysis ; Animals ; Astrocytes ; Astrocytes - metabolism ; Biological and medical sciences ; Blood ; Blood glucose ; Blood Glucose - metabolism ; Blood sugar ; Brain ; Causes of ; Citric Acid Cycle ; Company business management ; Diabetes ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Feedback, Physiological ; Glucose ; Glucose - administration & dosage ; Glucose - metabolism ; Glucose-6-Phosphatase - metabolism ; Homeostasis ; Hypoglycemia ; Hypothalamic regulation ; Hypothalamus - metabolism ; Inhibition ; Injections, Intraventricular ; Insulin ; Lactates ; Lactic Acid - metabolism ; Liver ; Liver - metabolism ; Male ; Management ; Medical sciences ; Messenger RNA ; Metabolism ; Neurons ; Neurons - metabolism ; Physiological aspects ; Potassium Channels - metabolism ; Pyruvates ; Pyruvates - metabolism ; Rats ; Rats, Sprague-Dawley ; Rodents</subject><ispartof>Science (American Association for the Advancement of Science), 2005-08, Vol.309 (5736), p.943-947</ispartof><rights>Copyright 2005 American Association for the Advancement of Science</rights><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 American Association for the Advancement of Science</rights><rights>COPYRIGHT 2005 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Aug 5, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c705t-dcfa219afd7806a7b8c6aa9cbfac44a85533d9e15434f401eaf26e6a75da7d6b3</citedby><cites>FETCH-LOGICAL-c705t-dcfa219afd7806a7b8c6aa9cbfac44a85533d9e15434f401eaf26e6a75da7d6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/3842609$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/3842609$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17004475$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16081739$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lam, Tony K. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2005-08, Vol.309 (5736), p.943-947 |
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| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Adenosine triphosphatase Analysis Animals Astrocytes Astrocytes - metabolism Biological and medical sciences Blood Blood glucose Blood Glucose - metabolism Blood sugar Brain Causes of Citric Acid Cycle Company business management Diabetes Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Feedback, Physiological Glucose Glucose - administration & dosage Glucose - metabolism Glucose-6-Phosphatase - metabolism Homeostasis Hypoglycemia Hypothalamic regulation Hypothalamus - metabolism Inhibition Injections, Intraventricular Insulin Lactates Lactic Acid - metabolism Liver Liver - metabolism Male Management Medical sciences Messenger RNA Metabolism Neurons Neurons - metabolism Physiological aspects Potassium Channels - metabolism Pyruvates Pyruvates - metabolism Rats Rats, Sprague-Dawley Rodents |
| title | Regulation of Blood Glucose by Hypothalamic Pyruvate Metabolism |
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