Reduced variation around drug-resistant dhfr alleles in African Plasmodium falciparum

We have measured microsatellite diversity at 26 markers around the dhfr gene in pyrimethamine-sensitive and -resistant parasites collected in southeast Africa. Through direct comparison with diversity on sensitive chromosomes we have found significant loss of diversity across a region of 70 kb aroun...

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Veröffentlicht in:	Molecular biology and evolution 2005-09, Vol.22 (9), p.1834-1844
Hauptverfasser:	Pearce, Richard, Malisa, Allen, Kachur, S Patrick, Barnes, Karen, Sharp, Brian, Roper, Cally
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa Alleles Animals Antimalarials - therapeutic use Drug Combinations Drug Resistance - genetics Gene Frequency Genes, Protozoan Genetic Variation Genome, Protozoan Humans Malaria, Falciparum - drug therapy Malaria, Falciparum - parasitology Microsatellite Repeats Mutation Plasmodium falciparum Plasmodium falciparum - genetics Pyrimethamine - therapeutic use Recombination, Genetic Retrospective Studies Selection, Genetic Sulfadoxine - therapeutic use
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