Analysis of low level radioactive metabolites in biological fluids using high-performance liquid chromatography with microplate scintillation counting: Method validation and application

TopCount, a microplate scintillation counter (MSC), has been recently employed as an off-line liquid radiochromatographic detector for radioactive metabolite profile analysis. The present study was undertaken to validate TopCount for metabolite profiling with respect to sensitivity, accuracy, precis...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2005-09, Vol.39 (1), p.233-245
Hauptverfasser:	Zhu, Mingshe, Zhao, Weiping, Vazquez, Natasha, Mitroka, James G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Analytical, structural and metabolic biochemistry Animals Benzofurans - analysis Biological and medical sciences Body Fluids - chemistry Buspirone - analysis Chromatography, High Pressure Liquid - methods Cyclopropanes - analysis Fundamental and applied biological sciences. Psychology General pharmacology Humans Male Medical sciences Metabolite profiling Microplate scintillation counter Pharmacology. Drug treatments Radiochromatographic detection Rats Rats, Sprague-Dawley Scintillation Counting Sensitivity and Specificity TopCount
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