Effect of acute changes of serum phosphate on fibroblast growth factor (FGF)23 levels in humans
Fibroblast growth factor (FGF)23 was identified as a humoral factor involved in the development of several hypophosphatemic diseases. Subsequent studies indicated that FGF23 is a hormone regulating serum phosphate level. However, it is still unknown how the production and serum level of FGF23 are re...
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| Veröffentlicht in: | Journal of bone and mineral metabolism 2007-11, Vol.25 (6), p.419-422 |
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| container_title | Journal of bone and mineral metabolism |
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| creator | ITO, Nobuaki FUKUMOTO, Seiji TAKEUCHI, Yasuhiro TAKEDA, Shu SUZUKI, Hisanori YAMASHITA, Takeyoshi FUJITA, Toshiro |
| description | Fibroblast growth factor (FGF)23 was identified as a humoral factor involved in the development of several hypophosphatemic diseases. Subsequent studies indicated that FGF23 is a hormone regulating serum phosphate level. However, it is still unknown how the production and serum level of FGF23 are regulated. This study was designed to determine whether acute changes of serum phosphate modulate FGF23 levels in human. Four healthy volunteers participated in the study. In the phosphate infusion study, dibasic potassium phosphate was infused at a rate of 10 mEq/h for 4 h, and serum FGF23 levels were measured for up to 6 h after the start of the infusion. In the carbohydrate study, partially hydrolyzed starch corresponding to 150 g glucose was ingested and FGF23 levels were measured similarly for 6 h. Phosphate infusion significantly increased and carbohydrate ingestion decreased serum phosphate levels, respectively. However, FGF23 did not change by these maneuvers. It is concluded that acute changes of serum phosphate do not modify FGF23 levels in the healthy human. |
| doi_str_mv | 10.1007/s00774-007-0779-3 |
| format | Article |
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Subsequent studies indicated that FGF23 is a hormone regulating serum phosphate level. However, it is still unknown how the production and serum level of FGF23 are regulated. This study was designed to determine whether acute changes of serum phosphate modulate FGF23 levels in human. Four healthy volunteers participated in the study. In the phosphate infusion study, dibasic potassium phosphate was infused at a rate of 10 mEq/h for 4 h, and serum FGF23 levels were measured for up to 6 h after the start of the infusion. In the carbohydrate study, partially hydrolyzed starch corresponding to 150 g glucose was ingested and FGF23 levels were measured similarly for 6 h. Phosphate infusion significantly increased and carbohydrate ingestion decreased serum phosphate levels, respectively. However, FGF23 did not change by these maneuvers. It is concluded that acute changes of serum phosphate do not modify FGF23 levels in the healthy human.</description><identifier>ISSN: 0914-8779</identifier><identifier>EISSN: 1435-5604</identifier><identifier>DOI: 10.1007/s00774-007-0779-3</identifier><identifier>PMID: 17968495</identifier><language>eng</language><publisher>Tokyo: Springer</publisher><subject>Adult ; Biological and medical sciences ; Carbohydrates ; Fibroblast Growth Factors - metabolism ; Humans ; Infusions, Intravenous ; Male ; Medical sciences ; Metabolic diseases ; Miscellaneous ; Other metabolic disorders ; Phosphates ; Phosphates - administration & dosage ; Phosphates - blood ; Phosphates - pharmacology ; Receptors, Fibroblast Growth Factor - metabolism</subject><ispartof>Journal of bone and mineral metabolism, 2007-11, Vol.25 (6), p.419-422</ispartof><rights>2007 INIST-CNRS</rights><rights>Springer-Verlag Tokyo 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-94a987c060f61b72c19b3c9a5eee059433c80a5350fe53f56d1ee10bcb5231cf3</citedby><cites>FETCH-LOGICAL-c476t-94a987c060f61b72c19b3c9a5eee059433c80a5350fe53f56d1ee10bcb5231cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19193862$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17968495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ITO, Nobuaki</creatorcontrib><creatorcontrib>FUKUMOTO, Seiji</creatorcontrib><creatorcontrib>TAKEUCHI, Yasuhiro</creatorcontrib><creatorcontrib>TAKEDA, Shu</creatorcontrib><creatorcontrib>SUZUKI, Hisanori</creatorcontrib><creatorcontrib>YAMASHITA, Takeyoshi</creatorcontrib><creatorcontrib>FUJITA, Toshiro</creatorcontrib><title>Effect of acute changes of serum phosphate on fibroblast growth factor (FGF)23 levels in humans</title><title>Journal of bone and mineral metabolism</title><addtitle>J Bone Miner Metab</addtitle><description>Fibroblast growth factor (FGF)23 was identified as a humoral factor involved in the development of several hypophosphatemic diseases. 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Subsequent studies indicated that FGF23 is a hormone regulating serum phosphate level. However, it is still unknown how the production and serum level of FGF23 are regulated. This study was designed to determine whether acute changes of serum phosphate modulate FGF23 levels in human. Four healthy volunteers participated in the study. In the phosphate infusion study, dibasic potassium phosphate was infused at a rate of 10 mEq/h for 4 h, and serum FGF23 levels were measured for up to 6 h after the start of the infusion. In the carbohydrate study, partially hydrolyzed starch corresponding to 150 g glucose was ingested and FGF23 levels were measured similarly for 6 h. Phosphate infusion significantly increased and carbohydrate ingestion decreased serum phosphate levels, respectively. However, FGF23 did not change by these maneuvers. It is concluded that acute changes of serum phosphate do not modify FGF23 levels in the healthy human.</abstract><cop>Tokyo</cop><pub>Springer</pub><pmid>17968495</pmid><doi>10.1007/s00774-007-0779-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of bone and mineral metabolism, 2007-11, Vol.25 (6), p.419-422 |
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| subjects | Adult Biological and medical sciences Carbohydrates Fibroblast Growth Factors - metabolism Humans Infusions, Intravenous Male Medical sciences Metabolic diseases Miscellaneous Other metabolic disorders Phosphates Phosphates - administration & dosage Phosphates - blood Phosphates - pharmacology Receptors, Fibroblast Growth Factor - metabolism |
| title | Effect of acute changes of serum phosphate on fibroblast growth factor (FGF)23 levels in humans |
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