Analysis of extrahepatic bile duct carcinomas according to the New American Joint Committee on Cancer staging system focused on tumor classification problems in 222 patients
BACKGROUND Although the sixth edition of the American Joint Committee on Cancer (AJCC) staging system for extrahepatic bile duct carcinoma was updated, the system has a problem on T classification due to its ambiguous definition of T1 as “tumor confined to bile duct histologically” and T2 as “tumor...
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| Veröffentlicht in: | Cancer 2005-08, Vol.104 (4), p.802-810 |
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| creator | Hong, Seung‐Mo Kim, Mi‐Jung Pi, David Y. Jo, Daniel Cho, Hyung Jun Yu, Eunsil Ro, Jae Y. |
| description | BACKGROUND
Although the sixth edition of the American Joint Committee on Cancer (AJCC) staging system for extrahepatic bile duct carcinoma was updated, the system has a problem on T classification due to its ambiguous definition of T1 as “tumor confined to bile duct histologically” and T2 as “tumor invading beyond the bile duct.”
METHODS
The authors considered the outermost part of the muscle layer or fibrous tissue as within the extrahepatic bile duct and considered the area starting from large clusters of adipose tissue as beyond the extrahepatic bile duct. After designing a precise definition of the extrahepatic bile duct wall, they analyzed the new AJCC staging system in 222 patients with of extrahepatic bile duct carcinomas. Then, other clinicopathologic variables for prognosis were evaluated using univariate and multivariate analyses.
RESULTS
The 5‐year survival rates for patients with tumors that were classified as T1, T2, T3, and T4 were 53.1%, 29.7%, 24.9%, and 0%, respectively. There was a significant difference in survival between patients with T1 tumors and T2 tumors (P < 0.05), but not between patients with T2 tumors and T3 tumors. Significant prognostic factors included depth of invasion (P < 0.005), lymph node metastasis (P < 0.005), and patient age (P < 0.05).
CONCLUSIONS
Based on a proposed histologic definition, depth of invasion was practical for evaluating the prognosis of patients with middle and upper extrahepatic bile duct carcinomas. Therefore, the authors recommended changing the current pT1 and pT2 classifications to more precise pathologic terminology. Cancer 2005. © 2005 American Cancer Society.
Although the sixth edition of the American Joint Committee on Cancer staging system for extrahepatic bile duct carcinoma was updated, the system has a problem with T classification due to some ambiguous definitions. The authors recommended changing the current pathologic tumor 1 (pT1) and pT2 classifications to more precise pathologic terminology. |
| doi_str_mv | 10.1002/cncr.21236 |
| format | Article |
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Although the sixth edition of the American Joint Committee on Cancer (AJCC) staging system for extrahepatic bile duct carcinoma was updated, the system has a problem on T classification due to its ambiguous definition of T1 as “tumor confined to bile duct histologically” and T2 as “tumor invading beyond the bile duct.”
METHODS
The authors considered the outermost part of the muscle layer or fibrous tissue as within the extrahepatic bile duct and considered the area starting from large clusters of adipose tissue as beyond the extrahepatic bile duct. After designing a precise definition of the extrahepatic bile duct wall, they analyzed the new AJCC staging system in 222 patients with of extrahepatic bile duct carcinomas. Then, other clinicopathologic variables for prognosis were evaluated using univariate and multivariate analyses.
RESULTS
The 5‐year survival rates for patients with tumors that were classified as T1, T2, T3, and T4 were 53.1%, 29.7%, 24.9%, and 0%, respectively. There was a significant difference in survival between patients with T1 tumors and T2 tumors (P < 0.05), but not between patients with T2 tumors and T3 tumors. Significant prognostic factors included depth of invasion (P < 0.005), lymph node metastasis (P < 0.005), and patient age (P < 0.05).
CONCLUSIONS
Based on a proposed histologic definition, depth of invasion was practical for evaluating the prognosis of patients with middle and upper extrahepatic bile duct carcinomas. Therefore, the authors recommended changing the current pT1 and pT2 classifications to more precise pathologic terminology. Cancer 2005. © 2005 American Cancer Society.
Although the sixth edition of the American Joint Committee on Cancer staging system for extrahepatic bile duct carcinoma was updated, the system has a problem with T classification due to some ambiguous definitions. The authors recommended changing the current pathologic tumor 1 (pT1) and pT2 classifications to more precise pathologic terminology.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.21236</identifier><identifier>PMID: 15959914</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Bile Duct Neoplasms - classification ; Bile Duct Neoplasms - mortality ; Bile Duct Neoplasms - pathology ; Bile Ducts, Extrahepatic - pathology ; Biological and medical sciences ; depth of invasion ; extrahepatic bile duct carcinoma ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Neoplasm Staging - methods ; Prognosis ; Survival Analysis ; T classification ; Tumors</subject><ispartof>Cancer, 2005-08, Vol.104 (4), p.802-810</ispartof><rights>Copyright © 2005 American Cancer Society</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4596-ab18ea1a2d9ab5bbf9d7566de641f4e489c3e6f8a77b8ff167759faf6e9f8c5b3</citedby><cites>FETCH-LOGICAL-c4596-ab18ea1a2d9ab5bbf9d7566de641f4e489c3e6f8a77b8ff167759faf6e9f8c5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.21236$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.21236$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16999887$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15959914$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hong, Seung‐Mo</creatorcontrib><creatorcontrib>Kim, Mi‐Jung</creatorcontrib><creatorcontrib>Pi, David Y.</creatorcontrib><creatorcontrib>Jo, Daniel</creatorcontrib><creatorcontrib>Cho, Hyung Jun</creatorcontrib><creatorcontrib>Yu, Eunsil</creatorcontrib><creatorcontrib>Ro, Jae Y.</creatorcontrib><title>Analysis of extrahepatic bile duct carcinomas according to the New American Joint Committee on Cancer staging system focused on tumor classification problems in 222 patients</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
Although the sixth edition of the American Joint Committee on Cancer (AJCC) staging system for extrahepatic bile duct carcinoma was updated, the system has a problem on T classification due to its ambiguous definition of T1 as “tumor confined to bile duct histologically” and T2 as “tumor invading beyond the bile duct.”
METHODS
The authors considered the outermost part of the muscle layer or fibrous tissue as within the extrahepatic bile duct and considered the area starting from large clusters of adipose tissue as beyond the extrahepatic bile duct. After designing a precise definition of the extrahepatic bile duct wall, they analyzed the new AJCC staging system in 222 patients with of extrahepatic bile duct carcinomas. Then, other clinicopathologic variables for prognosis were evaluated using univariate and multivariate analyses.
RESULTS
The 5‐year survival rates for patients with tumors that were classified as T1, T2, T3, and T4 were 53.1%, 29.7%, 24.9%, and 0%, respectively. There was a significant difference in survival between patients with T1 tumors and T2 tumors (P < 0.05), but not between patients with T2 tumors and T3 tumors. Significant prognostic factors included depth of invasion (P < 0.005), lymph node metastasis (P < 0.005), and patient age (P < 0.05).
CONCLUSIONS
Based on a proposed histologic definition, depth of invasion was practical for evaluating the prognosis of patients with middle and upper extrahepatic bile duct carcinomas. Therefore, the authors recommended changing the current pT1 and pT2 classifications to more precise pathologic terminology. Cancer 2005. © 2005 American Cancer Society.
Although the sixth edition of the American Joint Committee on Cancer staging system for extrahepatic bile duct carcinoma was updated, the system has a problem with T classification due to some ambiguous definitions. The authors recommended changing the current pathologic tumor 1 (pT1) and pT2 classifications to more precise pathologic terminology.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bile Duct Neoplasms - classification</subject><subject>Bile Duct Neoplasms - mortality</subject><subject>Bile Duct Neoplasms - pathology</subject><subject>Bile Ducts, Extrahepatic - pathology</subject><subject>Biological and medical sciences</subject><subject>depth of invasion</subject><subject>extrahepatic bile duct carcinoma</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Staging - methods</subject><subject>Prognosis</subject><subject>Survival Analysis</subject><subject>T classification</subject><subject>Tumors</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFu1DAQhiMEotvChQdAvsABKSX2xnZ8XEWFgqoiIZC4RRNn3Bol9uJxVPaheEcSdqXeOFljffPPaL6ieMWrS15V4r0NNl0KLrbqSbHhldFlxWvxtNhUVdWUst7-OCvOiX4upRZy-7w449JIY3i9Kf7sAowH8sSiY_g7J7jHPWRvWe9HZMNsM7OQrA9xAmJgbUyDD3csR5bvkd3iA9tNmLyFwD5HHzJr4zT5nBFZDKyFYDExynC3dtGBMk7MRTsTDiuQ5ykmZkcg8m5JyX753KfYjzgR84EJIdi6EYZML4pnDkbCl6f3ovj-4epbe13efPn4qd3dlLaWRpXQ8waBgxgM9LLvnRm0VGpAVXNXY90Yu0XlGtC6b5zjSmtpHDiFxjVW9tuL4u0xd1nk14yUu8mTxXGEgHGmTjW1FFqrBXx3BG2KRAldt09-gnToeNWtcrpVTvdPzgK_PqXO_YTDI3qysQBvTgCQhdGl5XieHjlljGkavXD8yD0sjg7_Gdm1t-3X4_C_9F-rmw</recordid><startdate>20050815</startdate><enddate>20050815</enddate><creator>Hong, Seung‐Mo</creator><creator>Kim, Mi‐Jung</creator><creator>Pi, David Y.</creator><creator>Jo, Daniel</creator><creator>Cho, Hyung Jun</creator><creator>Yu, Eunsil</creator><creator>Ro, Jae Y.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050815</creationdate><title>Analysis of extrahepatic bile duct carcinomas according to the New American Joint Committee on Cancer staging system focused on tumor classification problems in 222 patients</title><author>Hong, Seung‐Mo ; Kim, Mi‐Jung ; Pi, David Y. ; Jo, Daniel ; Cho, Hyung Jun ; Yu, Eunsil ; Ro, Jae Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4596-ab18ea1a2d9ab5bbf9d7566de641f4e489c3e6f8a77b8ff167759faf6e9f8c5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bile Duct Neoplasms - classification</topic><topic>Bile Duct Neoplasms - mortality</topic><topic>Bile Duct Neoplasms - pathology</topic><topic>Bile Ducts, Extrahepatic - pathology</topic><topic>Biological and medical sciences</topic><topic>depth of invasion</topic><topic>extrahepatic bile duct carcinoma</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Staging - methods</topic><topic>Prognosis</topic><topic>Survival Analysis</topic><topic>T classification</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hong, Seung‐Mo</creatorcontrib><creatorcontrib>Kim, Mi‐Jung</creatorcontrib><creatorcontrib>Pi, David Y.</creatorcontrib><creatorcontrib>Jo, Daniel</creatorcontrib><creatorcontrib>Cho, Hyung Jun</creatorcontrib><creatorcontrib>Yu, Eunsil</creatorcontrib><creatorcontrib>Ro, Jae Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hong, Seung‐Mo</au><au>Kim, Mi‐Jung</au><au>Pi, David Y.</au><au>Jo, Daniel</au><au>Cho, Hyung Jun</au><au>Yu, Eunsil</au><au>Ro, Jae Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of extrahepatic bile duct carcinomas according to the New American Joint Committee on Cancer staging system focused on tumor classification problems in 222 patients</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2005-08-15</date><risdate>2005</risdate><volume>104</volume><issue>4</issue><spage>802</spage><epage>810</epage><pages>802-810</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
Although the sixth edition of the American Joint Committee on Cancer (AJCC) staging system for extrahepatic bile duct carcinoma was updated, the system has a problem on T classification due to its ambiguous definition of T1 as “tumor confined to bile duct histologically” and T2 as “tumor invading beyond the bile duct.”
METHODS
The authors considered the outermost part of the muscle layer or fibrous tissue as within the extrahepatic bile duct and considered the area starting from large clusters of adipose tissue as beyond the extrahepatic bile duct. After designing a precise definition of the extrahepatic bile duct wall, they analyzed the new AJCC staging system in 222 patients with of extrahepatic bile duct carcinomas. Then, other clinicopathologic variables for prognosis were evaluated using univariate and multivariate analyses.
RESULTS
The 5‐year survival rates for patients with tumors that were classified as T1, T2, T3, and T4 were 53.1%, 29.7%, 24.9%, and 0%, respectively. There was a significant difference in survival between patients with T1 tumors and T2 tumors (P < 0.05), but not between patients with T2 tumors and T3 tumors. Significant prognostic factors included depth of invasion (P < 0.005), lymph node metastasis (P < 0.005), and patient age (P < 0.05).
CONCLUSIONS
Based on a proposed histologic definition, depth of invasion was practical for evaluating the prognosis of patients with middle and upper extrahepatic bile duct carcinomas. Therefore, the authors recommended changing the current pT1 and pT2 classifications to more precise pathologic terminology. Cancer 2005. © 2005 American Cancer Society.
Although the sixth edition of the American Joint Committee on Cancer staging system for extrahepatic bile duct carcinoma was updated, the system has a problem with T classification due to some ambiguous definitions. The authors recommended changing the current pathologic tumor 1 (pT1) and pT2 classifications to more precise pathologic terminology.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15959914</pmid><doi>10.1002/cncr.21236</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Bile Duct Neoplasms - classification Bile Duct Neoplasms - mortality Bile Duct Neoplasms - pathology Bile Ducts, Extrahepatic - pathology Biological and medical sciences depth of invasion extrahepatic bile duct carcinoma Female Humans Male Medical sciences Middle Aged Neoplasm Staging - methods Prognosis Survival Analysis T classification Tumors |
| title | Analysis of extrahepatic bile duct carcinomas according to the New American Joint Committee on Cancer staging system focused on tumor classification problems in 222 patients |
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