Cyclin D1 polymorphism (G870A) and risk for esophageal adenocarcinoma

BACKGROUND To investigate individual susceptibility to gastroesophageal reflux disease, Barrett esophagus, and esophageal adenocarcinoma, the authors studied the frequency of the common G870A polymorphism of CCND1, which encodes cyclin D1, a key cell cycle regulatory protein. METHODS The study popul...

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Veröffentlicht in:	Cancer 2005-08, Vol.104 (4), p.730-739
Hauptverfasser:	Casson, Alan G., Zheng, Zuoyu, Evans, Susan C., Geldenhuys, Laurette, van Zanten, Sander Veldhuyzen, Veugelers, Paul J., Porter, Geoffrey A., Guernsey, Duane L.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - metabolism Barrett epithelium Barrett Esophagus - genetics Barrett Esophagus - metabolism Biological and medical sciences CCND1 cyclin D1 Cyclin D1 - genetics Cyclin D1 - metabolism Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophagus Gastroenterology. Liver. Pancreas. Abdomen Gastroesophageal Reflux - genetics Gastroesophageal Reflux - metabolism gastroesophageal reflux disease Gene Frequency Genetic Predisposition to Disease Genotype Humans Immunohistochemistry Medical sciences Other diseases. Semiology Polymerase Chain Reaction polymorphism Polymorphism, Genetic Precancerous Conditions - genetics Precancerous Conditions - metabolism Risk Factors Tumors
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