Therapeutic Strategies for Targeting the IL-6/STAT3 Cytokine Signaling Pathway in Inflammatory Bowel Disease

Interleukin-6 (IL-6) is a pleiotropic cytokine with central roles in immune and inflammatory reactions. IL-6 first binds to the IL-6 receptor (IL-6R), this complex then associates with gp130, inducing dimerization and the initiation of signaling through signal transducer and activator of transcripti...

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Veröffentlicht in:	Anticancer research 2007-11, Vol.27 (6A), p.3749-3756
Hauptverfasser:	MITSUYAMA, Keiichi, MATSUMOTO, Satoshi, MASUDA, Junya, YAMASAKI, Hiroshi, KUWAKI, Kotaro, TAKEDATSU, Hidetoshi, SATA, Michio
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cytokine Receptor gp130 - metabolism Drug Delivery Systems Gastroenterology. Liver. Pancreas. Abdomen Humans Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - metabolism Interleukin-6 - antagonists & inhibitors Interleukin-6 - metabolism Medical sciences Models, Biological Other diseases. Semiology Signal Transduction STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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