Prophylactic antiemetic effect of midazolam after middle ear surgery
To investigate the prophylactic antiemetic effect of midazolam after middle ear surgery. A prospective, randomized, double-blind, placebo-controlled study. Ninety women patients undergoing middle ear surgery with general anesthesia received intravenously either midazolam 0.075 mg/kg or normal saline...
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| Veröffentlicht in: | Otolaryngology-head and neck surgery 2007-11, Vol.137 (5), p.753-756 |
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| container_issue | 5 |
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| container_title | Otolaryngology-head and neck surgery |
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| creator | Jung, Jae Sik Park, Jun Sik Kim, Si Oh Lim, Dong Gun Park, Sung Sik Kwak, Kyung Hwa Cho, Jin Duck Jeon, Young Hoon |
| description | To investigate the prophylactic antiemetic effect of midazolam after middle ear surgery.
A prospective, randomized, double-blind, placebo-controlled study.
Ninety women patients undergoing middle ear surgery with general anesthesia received intravenously either midazolam 0.075 mg/kg or normal saline (n = 45 each) after induction of anesthesia. The incidence and severity of postoperative nausea and vomiting, rescue antiemetics, pain intensity, and side effects such as headache, dizziness, and drowsiness were assessed during the first 24 hours after anesthesia.
Midazolam groups showed total incidence and severity of nausea and vomiting. Patients who required rescue antiemetics were significantly lower than in saline group (
P < 0.05), but there were no significant differences in pain intensity and side effects such as headache, dizziness, and drowsiness between groups.
Midazolam 0.075 mg/kg is effective for reducing nausea and vomiting after middle ear surgery. |
| doi_str_mv | 10.1016/j.otohns.2007.07.024 |
| format | Article |
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A prospective, randomized, double-blind, placebo-controlled study.
Ninety women patients undergoing middle ear surgery with general anesthesia received intravenously either midazolam 0.075 mg/kg or normal saline (n = 45 each) after induction of anesthesia. The incidence and severity of postoperative nausea and vomiting, rescue antiemetics, pain intensity, and side effects such as headache, dizziness, and drowsiness were assessed during the first 24 hours after anesthesia.
Midazolam groups showed total incidence and severity of nausea and vomiting. Patients who required rescue antiemetics were significantly lower than in saline group (
P < 0.05), but there were no significant differences in pain intensity and side effects such as headache, dizziness, and drowsiness between groups.
Midazolam 0.075 mg/kg is effective for reducing nausea and vomiting after middle ear surgery.</description><identifier>ISSN: 0194-5998</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1016/j.otohns.2007.07.024</identifier><identifier>PMID: 17967640</identifier><language>eng</language><publisher>Los Angeles, CA: Mosby, Inc</publisher><subject>Antiemetics - administration & dosage ; Antiemetics - standards ; Antiemetics - therapeutic use ; Double-Blind Method ; Ear, Middle - surgery ; Female ; Humans ; Hypnotics and Sedatives - administration & dosage ; Hypnotics and Sedatives - therapeutic use ; Injections, Intravenous ; Midazolam - administration & dosage ; Midazolam - therapeutic use ; Middle Aged ; Prospective Studies ; Tympanoplasty</subject><ispartof>Otolaryngology-head and neck surgery, 2007-11, Vol.137 (5), p.753-756</ispartof><rights>2007 American Academy of Otolaryngology–Head and Neck Surgery Foundation</rights><rights>2007 SAGE Publications</rights><rights>2007 American Association of Otolaryngology‐Head and Neck Surgery Foundation (AAO‐HNSF)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5012-1d1d577a078b1b8fe87d509390bc4428cc9f2a273dc1a1582e1b81fbf72cd9e83</citedby><cites>FETCH-LOGICAL-c5012-1d1d577a078b1b8fe87d509390bc4428cc9f2a273dc1a1582e1b81fbf72cd9e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1016/j.otohns.2007.07.024$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1016/j.otohns.2007.07.024$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,1416,21817,27922,27923,43619,43620,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17967640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jung, Jae Sik</creatorcontrib><creatorcontrib>Park, Jun Sik</creatorcontrib><creatorcontrib>Kim, Si Oh</creatorcontrib><creatorcontrib>Lim, Dong Gun</creatorcontrib><creatorcontrib>Park, Sung Sik</creatorcontrib><creatorcontrib>Kwak, Kyung Hwa</creatorcontrib><creatorcontrib>Cho, Jin Duck</creatorcontrib><creatorcontrib>Jeon, Young Hoon</creatorcontrib><title>Prophylactic antiemetic effect of midazolam after middle ear surgery</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description>To investigate the prophylactic antiemetic effect of midazolam after middle ear surgery.
A prospective, randomized, double-blind, placebo-controlled study.
Ninety women patients undergoing middle ear surgery with general anesthesia received intravenously either midazolam 0.075 mg/kg or normal saline (n = 45 each) after induction of anesthesia. The incidence and severity of postoperative nausea and vomiting, rescue antiemetics, pain intensity, and side effects such as headache, dizziness, and drowsiness were assessed during the first 24 hours after anesthesia.
Midazolam groups showed total incidence and severity of nausea and vomiting. Patients who required rescue antiemetics were significantly lower than in saline group (
P < 0.05), but there were no significant differences in pain intensity and side effects such as headache, dizziness, and drowsiness between groups.
Midazolam 0.075 mg/kg is effective for reducing nausea and vomiting after middle ear surgery.</description><subject>Antiemetics - administration & dosage</subject><subject>Antiemetics - standards</subject><subject>Antiemetics - therapeutic use</subject><subject>Double-Blind Method</subject><subject>Ear, Middle - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Hypnotics and Sedatives - administration & dosage</subject><subject>Hypnotics and Sedatives - therapeutic use</subject><subject>Injections, Intravenous</subject><subject>Midazolam - administration & dosage</subject><subject>Midazolam - therapeutic use</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Tympanoplasty</subject><issn>0194-5998</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1q3DAURkVoSSZp3iAUr7rzRFdjWxKEQPNfCE0XyVrI0lWiwbamkp0wffrYeKC7tHBBEpzv43JEyAnQJVCoTtfL0IeXLi0ZpXw5DSv2yAKo5HklgH8iCwqyyEspxQE5TGlNKa0qzvfJAXBZ8aqgC3L1K4bNy7bRpvcm013vscXpis6h6bPgstZb_Sc0us206zFOb9tghjpmaYjPGLdfyGenm4THu_OIPN1cP17e5fcPtz8uv9_npqTAcrBgS8415aKGWjgU3JZUriStTVEwYYx0TDO-sgY0lILhSIGrHWfGShSrI_Jt7t3E8HvA1KvWJ4NNozsMQ1KVKEooOYxgMYMmhpQiOrWJvtVxq4CqyZ5aq9memuypaVgxxr7u-oe6Rfs3tNM1Amcz8OYb3P5XqXq4-3lxw4CWbIzDHE_6GdU6DLEbdf1rp_M5g6PYV49RJeOxM2h9HD9I2eA_LngHAzemBw</recordid><startdate>200711</startdate><enddate>200711</enddate><creator>Jung, Jae Sik</creator><creator>Park, Jun Sik</creator><creator>Kim, Si Oh</creator><creator>Lim, Dong Gun</creator><creator>Park, Sung Sik</creator><creator>Kwak, Kyung Hwa</creator><creator>Cho, Jin Duck</creator><creator>Jeon, Young Hoon</creator><general>Mosby, Inc</general><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200711</creationdate><title>Prophylactic antiemetic effect of midazolam after middle ear surgery</title><author>Jung, Jae Sik ; Park, Jun Sik ; Kim, Si Oh ; Lim, Dong Gun ; Park, Sung Sik ; Kwak, Kyung Hwa ; Cho, Jin Duck ; Jeon, Young Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5012-1d1d577a078b1b8fe87d509390bc4428cc9f2a273dc1a1582e1b81fbf72cd9e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Antiemetics - administration & dosage</topic><topic>Antiemetics - standards</topic><topic>Antiemetics - therapeutic use</topic><topic>Double-Blind Method</topic><topic>Ear, Middle - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Hypnotics and Sedatives - administration & dosage</topic><topic>Hypnotics and Sedatives - therapeutic use</topic><topic>Injections, Intravenous</topic><topic>Midazolam - administration & dosage</topic><topic>Midazolam - therapeutic use</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Tympanoplasty</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jung, Jae Sik</creatorcontrib><creatorcontrib>Park, Jun Sik</creatorcontrib><creatorcontrib>Kim, Si Oh</creatorcontrib><creatorcontrib>Lim, Dong Gun</creatorcontrib><creatorcontrib>Park, Sung Sik</creatorcontrib><creatorcontrib>Kwak, Kyung Hwa</creatorcontrib><creatorcontrib>Cho, Jin Duck</creatorcontrib><creatorcontrib>Jeon, Young Hoon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jung, Jae Sik</au><au>Park, Jun Sik</au><au>Kim, Si Oh</au><au>Lim, Dong Gun</au><au>Park, Sung Sik</au><au>Kwak, Kyung Hwa</au><au>Cho, Jin Duck</au><au>Jeon, Young Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prophylactic antiemetic effect of midazolam after middle ear surgery</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2007-11</date><risdate>2007</risdate><volume>137</volume><issue>5</issue><spage>753</spage><epage>756</epage><pages>753-756</pages><issn>0194-5998</issn><eissn>1097-6817</eissn><abstract>To investigate the prophylactic antiemetic effect of midazolam after middle ear surgery.
A prospective, randomized, double-blind, placebo-controlled study.
Ninety women patients undergoing middle ear surgery with general anesthesia received intravenously either midazolam 0.075 mg/kg or normal saline (n = 45 each) after induction of anesthesia. The incidence and severity of postoperative nausea and vomiting, rescue antiemetics, pain intensity, and side effects such as headache, dizziness, and drowsiness were assessed during the first 24 hours after anesthesia.
Midazolam groups showed total incidence and severity of nausea and vomiting. Patients who required rescue antiemetics were significantly lower than in saline group (
P < 0.05), but there were no significant differences in pain intensity and side effects such as headache, dizziness, and drowsiness between groups.
Midazolam 0.075 mg/kg is effective for reducing nausea and vomiting after middle ear surgery.</abstract><cop>Los Angeles, CA</cop><pub>Mosby, Inc</pub><pmid>17967640</pmid><doi>10.1016/j.otohns.2007.07.024</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Otolaryngology-head and neck surgery, 2007-11, Vol.137 (5), p.753-756 |
| issn | 0194-5998 1097-6817 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SAGE Complete A-Z List; Alma/SFX Local Collection |
| subjects | Antiemetics - administration & dosage Antiemetics - standards Antiemetics - therapeutic use Double-Blind Method Ear, Middle - surgery Female Humans Hypnotics and Sedatives - administration & dosage Hypnotics and Sedatives - therapeutic use Injections, Intravenous Midazolam - administration & dosage Midazolam - therapeutic use Middle Aged Prospective Studies Tympanoplasty |
| title | Prophylactic antiemetic effect of midazolam after middle ear surgery |
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