A Role for IL-27 in Early Regulation of Th1 Differentiation

IL-27 is a novel IL-6/IL-12 family cytokine that is considered to play a role in Th1 differentiation, whereas the exact role of IL-27 in Th1 differentiation and its molecular mechanism remain unclear. In this study we demonstrate a role for IL-27 in the early regulation of Th1 differentiation and it...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-08, Vol.175 (4), p.2191-2200
Hauptverfasser:	Owaki, Toshiyuki, Asakawa, Masayuki, Morishima, Noriko, Hata, Kikumi, Fukai, Fumio, Matsui, Masanori, Mizuguchi, Junichiro, Yoshimoto, Takayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Presenting Cells - immunology CD28 Antigens - immunology CD3 Complex - immunology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell Differentiation - genetics Cell Differentiation - immunology Cell Line, Tumor Immune Sera - pharmacology Immunity, Cellular - genetics Intercellular Adhesion Molecule-1 - biosynthesis Intercellular Adhesion Molecule-1 - genetics Interferon-gamma - deficiency Interferon-gamma - genetics Interferon-gamma - physiology Interleukin-12 - deficiency Interleukin-12 - genetics Interleukin-12 - physiology Interleukin-12 Subunit p40 Interleukins - administration & dosage Interleukins - physiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Protein Subunits - deficiency Protein Subunits - genetics Protein Subunits - physiology Resting Phase, Cell Cycle - immunology Th1 Cells - cytology Th1 Cells - immunology Th1 Cells - metabolism Up-Regulation - immunology
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