Soluble CD44v6 is Not a Sensitive Tumor Marker in Patients with Head and Neck Squamous Cell Cancer
Background: In some epithelial tumors, isoforms of CD44 are overexpressed and soluble isoforms detectable in serum samples are elevated. In squamous cell cancer of the head and neck (SCCHN) the alteration of CD44 isoforms could be associated with poor prognosis. A comprehensive study was undertaken...
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| Veröffentlicht in: | Anticancer research 2005-07, Vol.25 (4), p.2821-2826 |
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| container_title | Anticancer research |
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| creator | ANDRATSCHKE, Michaela CHAUBAL, Sarita PAULI, Christof MACK, Brigitte HAGEDORN, Hjalmar WOLLENBERG, Barbara |
| description | Background: In some epithelial tumors, isoforms of CD44 are overexpressed and soluble isoforms detectable in serum samples
are elevated. In squamous cell cancer of the head and neck (SCCHN) the alteration of CD44 isoforms could be associated with
poor prognosis. A comprehensive study was undertaken to examine the value of CD44v6 as a tumor marker for SCCHN. Patients
and Methods: Serum samples of SCCHN and healthy smokers were analyzed for soluble CD44v6 by ELISA. The expression of CD44
isoforms was determined by immunohistochemical staining of healthy and dysplastic tissue. Results: There was no significant
difference between the serum levels of sCD44v6 in SCCHN and healthy smokers. Nor was there a correlation between the serum
level of sCD44v6 and UICC stage, TNM stage or histological grading. In tissue of primary SCCHN, expression of CD44v6 was found
as a strong, specific staining of the lower epithelial layers. Similar amounts of CD44v6-positive-labelled tumor cells were
found in invasive carcinoma. Conclusion: Soluble CD44v6 is not a valuable tumor marker for SCCHN since the soluble form appears
to be present in healthy smokers and does not reflect the stage of the disease. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68450930</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68450930</sourcerecordid><originalsourceid>FETCH-LOGICAL-h269t-d8b3494899fa5226d1966231f038804792a9ed3f554f8d0e301f68008ef1a4da3</originalsourceid><addsrcrecordid>eNpN0ElLxEAQBeAgijOO_gXpi94Cld7SfZS4jOAGo-dQk1RMO1m0Oxnx3xtwRE91-Xi8V3vRPEltEqdKwH40B64gTgHULDoK4Q1Aa2vEYTRLNBhQgs-j9apvxnVDLLuUcquZC-yhHxiyFXXBDW5L7Hlse8_u0W_IM9exJxwcdUNgn26o2ZKwZNiV7IGKDVt9jNj2Y2AZNQ3LsCvIH0cHFTaBTnZ3Eb1cXz1ny_ju8eY2u7iLa67tEJdmLaSVxtoKFee6TKzWXCQVCGNAppajpVJUSsnKlEACkkobAENVgrJEsYjOf3Lfff8xUhjy1oVi6oEdTZVybaQCK2CCpzs4rlsq83fvWvRf-e9XJnC2AxgKbCo_7XDhn7Op5qn8c7V7rT-dpzy02DRTrMjRc5XLnBueiG8AenYf</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68450930</pqid></control><display><type>article</type><title>Soluble CD44v6 is Not a Sensitive Tumor Marker in Patients with Head and Neck Squamous Cell Cancer</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>ANDRATSCHKE, Michaela ; CHAUBAL, Sarita ; PAULI, Christof ; MACK, Brigitte ; HAGEDORN, Hjalmar ; WOLLENBERG, Barbara</creator><creatorcontrib>ANDRATSCHKE, Michaela ; CHAUBAL, Sarita ; PAULI, Christof ; MACK, Brigitte ; HAGEDORN, Hjalmar ; WOLLENBERG, Barbara</creatorcontrib><description>Background: In some epithelial tumors, isoforms of CD44 are overexpressed and soluble isoforms detectable in serum samples
are elevated. In squamous cell cancer of the head and neck (SCCHN) the alteration of CD44 isoforms could be associated with
poor prognosis. A comprehensive study was undertaken to examine the value of CD44v6 as a tumor marker for SCCHN. Patients
and Methods: Serum samples of SCCHN and healthy smokers were analyzed for soluble CD44v6 by ELISA. The expression of CD44
isoforms was determined by immunohistochemical staining of healthy and dysplastic tissue. Results: There was no significant
difference between the serum levels of sCD44v6 in SCCHN and healthy smokers. Nor was there a correlation between the serum
level of sCD44v6 and UICC stage, TNM stage or histological grading. In tissue of primary SCCHN, expression of CD44v6 was found
as a strong, specific staining of the lower epithelial layers. Similar amounts of CD44v6-positive-labelled tumor cells were
found in invasive carcinoma. Conclusion: Soluble CD44v6 is not a valuable tumor marker for SCCHN since the soluble form appears
to be present in healthy smokers and does not reflect the stage of the disease.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 16080532</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Biological and medical sciences ; Biomarkers, Tumor - blood ; Carcinoma, Squamous Cell - blood ; Carcinoma, Squamous Cell - pathology ; Cell Differentiation - physiology ; Enzyme-Linked Immunosorbent Assay ; Glycoproteins - blood ; Head and Neck Neoplasms - blood ; Head and Neck Neoplasms - pathology ; Humans ; Hyaluronan Receptors - blood ; Immunohistochemistry ; Medical sciences ; Neoplasm Invasiveness ; Neoplasm Staging ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Sensitivity and Specificity ; Tumors</subject><ispartof>Anticancer research, 2005-07, Vol.25 (4), p.2821-2826</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16976274$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16080532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ANDRATSCHKE, Michaela</creatorcontrib><creatorcontrib>CHAUBAL, Sarita</creatorcontrib><creatorcontrib>PAULI, Christof</creatorcontrib><creatorcontrib>MACK, Brigitte</creatorcontrib><creatorcontrib>HAGEDORN, Hjalmar</creatorcontrib><creatorcontrib>WOLLENBERG, Barbara</creatorcontrib><title>Soluble CD44v6 is Not a Sensitive Tumor Marker in Patients with Head and Neck Squamous Cell Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: In some epithelial tumors, isoforms of CD44 are overexpressed and soluble isoforms detectable in serum samples
are elevated. In squamous cell cancer of the head and neck (SCCHN) the alteration of CD44 isoforms could be associated with
poor prognosis. A comprehensive study was undertaken to examine the value of CD44v6 as a tumor marker for SCCHN. Patients
and Methods: Serum samples of SCCHN and healthy smokers were analyzed for soluble CD44v6 by ELISA. The expression of CD44
isoforms was determined by immunohistochemical staining of healthy and dysplastic tissue. Results: There was no significant
difference between the serum levels of sCD44v6 in SCCHN and healthy smokers. Nor was there a correlation between the serum
level of sCD44v6 and UICC stage, TNM stage or histological grading. In tissue of primary SCCHN, expression of CD44v6 was found
as a strong, specific staining of the lower epithelial layers. Similar amounts of CD44v6-positive-labelled tumor cells were
found in invasive carcinoma. Conclusion: Soluble CD44v6 is not a valuable tumor marker for SCCHN since the soluble form appears
to be present in healthy smokers and does not reflect the stage of the disease.</description><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>Carcinoma, Squamous Cell - blood</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Differentiation - physiology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Glycoproteins - blood</subject><subject>Head and Neck Neoplasms - blood</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Humans</subject><subject>Hyaluronan Receptors - blood</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Sensitivity and Specificity</subject><subject>Tumors</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0ElLxEAQBeAgijOO_gXpi94Cld7SfZS4jOAGo-dQk1RMO1m0Oxnx3xtwRE91-Xi8V3vRPEltEqdKwH40B64gTgHULDoK4Q1Aa2vEYTRLNBhQgs-j9apvxnVDLLuUcquZC-yhHxiyFXXBDW5L7Hlse8_u0W_IM9exJxwcdUNgn26o2ZKwZNiV7IGKDVt9jNj2Y2AZNQ3LsCvIH0cHFTaBTnZ3Eb1cXz1ny_ju8eY2u7iLa67tEJdmLaSVxtoKFee6TKzWXCQVCGNAppajpVJUSsnKlEACkkobAENVgrJEsYjOf3Lfff8xUhjy1oVi6oEdTZVybaQCK2CCpzs4rlsq83fvWvRf-e9XJnC2AxgKbCo_7XDhn7Op5qn8c7V7rT-dpzy02DRTrMjRc5XLnBueiG8AenYf</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>ANDRATSCHKE, Michaela</creator><creator>CHAUBAL, Sarita</creator><creator>PAULI, Christof</creator><creator>MACK, Brigitte</creator><creator>HAGEDORN, Hjalmar</creator><creator>WOLLENBERG, Barbara</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Soluble CD44v6 is Not a Sensitive Tumor Marker in Patients with Head and Neck Squamous Cell Cancer</title><author>ANDRATSCHKE, Michaela ; CHAUBAL, Sarita ; PAULI, Christof ; MACK, Brigitte ; HAGEDORN, Hjalmar ; WOLLENBERG, Barbara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-d8b3494899fa5226d1966231f038804792a9ed3f554f8d0e301f68008ef1a4da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - blood</topic><topic>Carcinoma, Squamous Cell - blood</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Differentiation - physiology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Glycoproteins - blood</topic><topic>Head and Neck Neoplasms - blood</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Humans</topic><topic>Hyaluronan Receptors - blood</topic><topic>Immunohistochemistry</topic><topic>Medical sciences</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Sensitivity and Specificity</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ANDRATSCHKE, Michaela</creatorcontrib><creatorcontrib>CHAUBAL, Sarita</creatorcontrib><creatorcontrib>PAULI, Christof</creatorcontrib><creatorcontrib>MACK, Brigitte</creatorcontrib><creatorcontrib>HAGEDORN, Hjalmar</creatorcontrib><creatorcontrib>WOLLENBERG, Barbara</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ANDRATSCHKE, Michaela</au><au>CHAUBAL, Sarita</au><au>PAULI, Christof</au><au>MACK, Brigitte</au><au>HAGEDORN, Hjalmar</au><au>WOLLENBERG, Barbara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soluble CD44v6 is Not a Sensitive Tumor Marker in Patients with Head and Neck Squamous Cell Cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>25</volume><issue>4</issue><spage>2821</spage><epage>2826</epage><pages>2821-2826</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: In some epithelial tumors, isoforms of CD44 are overexpressed and soluble isoforms detectable in serum samples
are elevated. In squamous cell cancer of the head and neck (SCCHN) the alteration of CD44 isoforms could be associated with
poor prognosis. A comprehensive study was undertaken to examine the value of CD44v6 as a tumor marker for SCCHN. Patients
and Methods: Serum samples of SCCHN and healthy smokers were analyzed for soluble CD44v6 by ELISA. The expression of CD44
isoforms was determined by immunohistochemical staining of healthy and dysplastic tissue. Results: There was no significant
difference between the serum levels of sCD44v6 in SCCHN and healthy smokers. Nor was there a correlation between the serum
level of sCD44v6 and UICC stage, TNM stage or histological grading. In tissue of primary SCCHN, expression of CD44v6 was found
as a strong, specific staining of the lower epithelial layers. Similar amounts of CD44v6-positive-labelled tumor cells were
found in invasive carcinoma. Conclusion: Soluble CD44v6 is not a valuable tumor marker for SCCHN since the soluble form appears
to be present in healthy smokers and does not reflect the stage of the disease.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>16080532</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Anticancer research, 2005-07, Vol.25 (4), p.2821-2826 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Biological and medical sciences Biomarkers, Tumor - blood Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - pathology Cell Differentiation - physiology Enzyme-Linked Immunosorbent Assay Glycoproteins - blood Head and Neck Neoplasms - blood Head and Neck Neoplasms - pathology Humans Hyaluronan Receptors - blood Immunohistochemistry Medical sciences Neoplasm Invasiveness Neoplasm Staging Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Sensitivity and Specificity Tumors |
| title | Soluble CD44v6 is Not a Sensitive Tumor Marker in Patients with Head and Neck Squamous Cell Cancer |
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