Quantitative Assessment of Gliomas by Proton Magnetic Resonance Spectroscopy
Background: Advanced magnetic resonance (MR) techniques provide physiological and metabolic information that complements the anatomical information available from conventional MR imaging. The purpose of this study was to evaluate the clinical usefulness of proton MR spectroscopy ( 1 H-MRS) in preope...
Gespeichert in:
| Veröffentlicht in: | Anticancer research 2007-11, Vol.27 (6A), p.3757-3763 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3763 |
|---|---|
| container_issue | 6A |
| container_start_page | 3757 |
| container_title | Anticancer research |
| container_volume | 27 |
| creator | OSHIRO, Shinya TSUGU, Hitoshi KOMATSU, Fuminari ABE, Hiroshi ONISHI, Hirokazu OHMURA, Tadahiro IWAASA, Mitsutoshi SAKAMOTO, Seisaburo FUKUSHIMA, Takeo |
| description | Background: Advanced magnetic resonance (MR) techniques provide physiological and metabolic information that complements the
anatomical information available from conventional MR imaging. The purpose of this study was to evaluate the clinical usefulness
of proton MR spectroscopy ( 1 H-MRS) in preoperative quantitative assessment of intracranial gliomas. Patients and Methods: Eight patients with histologically
verified gliomas, comprising 2 cases with glioblastoma multiforme (GBM, grade 4), 5 cases with anaplastic oligodendroglioma
(AO, grade 3; high-grade glioma), and 1 case with fibrillary astrocytoma (FA, grade 2; low-grade glioma) were evaluated using
the 1 H-MRS protocol following conventional MR imaging, diffusion-weighted imaging (DWI), and perfusion-weighted imaging (PWI) preoperatively.
Results: High-grade gliomas tended to demonstrate signal hyperintensity by DWI and higher relative cerebral blood volume (rCBV)
by PWI. Increased ratios of choline (Cho) to N-acetylaspartate (NAA) (Cho/NAA) and Cho to creatine (Cr) (Cho/Cr) correlated
highly with tumor malignancy. The presence of lactate and lipid was predominately detected in patients with high-grade glioma.
Conclusion: The combination of multiple MR parameters, based on DWI, PWI and 1 H-MRS, appears valuable for preoperatively predicting the degree of malignancy in glioma. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68450831</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68450831</sourcerecordid><originalsourceid>FETCH-LOGICAL-h270t-c89046b737576db1702c38c37fbb042fca0004ce5facded0d23b6dd1fda886db3</originalsourceid><addsrcrecordid>eNpFz01LxDAQBuAgiruu_gXJRW-FadM27XFZdBVW_D6HNEl3I21TM6nSf2_FlT0NDM-8w3tE5jEv44hnDI7JHJIMIg6QzcgZ4gdAnpcFOyWzCU1rVs7J5nmQXbBBBvtl6BLRILamC9TVdN1Y10qk1UifvAuuow9y25lgFX0x6DrZKUNfe6OCd6hcP56Tk1o2aC72c0Heb2_eVnfR5nF9v1puol3CIUSqKCHNK854xnNdxRwSxQrFeF1VkCa1kgCQKpPVUmmjQSesyrWOay2LYjpgC3L9l9t79zkYDKK1qEzTyM64AUVepBkULJ7g5R4OVWu06L1tpR_Ff_8JXO2BRCWb2k-dLB5cGZe8ZMnh485ud9_WG4GtbJoplgnpEy7ypfitw34AWHBy2A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68450831</pqid></control><display><type>article</type><title>Quantitative Assessment of Gliomas by Proton Magnetic Resonance Spectroscopy</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>OSHIRO, Shinya ; TSUGU, Hitoshi ; KOMATSU, Fuminari ; ABE, Hiroshi ; ONISHI, Hirokazu ; OHMURA, Tadahiro ; IWAASA, Mitsutoshi ; SAKAMOTO, Seisaburo ; FUKUSHIMA, Takeo</creator><creatorcontrib>OSHIRO, Shinya ; TSUGU, Hitoshi ; KOMATSU, Fuminari ; ABE, Hiroshi ; ONISHI, Hirokazu ; OHMURA, Tadahiro ; IWAASA, Mitsutoshi ; SAKAMOTO, Seisaburo ; FUKUSHIMA, Takeo</creatorcontrib><description>Background: Advanced magnetic resonance (MR) techniques provide physiological and metabolic information that complements the
anatomical information available from conventional MR imaging. The purpose of this study was to evaluate the clinical usefulness
of proton MR spectroscopy ( 1 H-MRS) in preoperative quantitative assessment of intracranial gliomas. Patients and Methods: Eight patients with histologically
verified gliomas, comprising 2 cases with glioblastoma multiforme (GBM, grade 4), 5 cases with anaplastic oligodendroglioma
(AO, grade 3; high-grade glioma), and 1 case with fibrillary astrocytoma (FA, grade 2; low-grade glioma) were evaluated using
the 1 H-MRS protocol following conventional MR imaging, diffusion-weighted imaging (DWI), and perfusion-weighted imaging (PWI) preoperatively.
Results: High-grade gliomas tended to demonstrate signal hyperintensity by DWI and higher relative cerebral blood volume (rCBV)
by PWI. Increased ratios of choline (Cho) to N-acetylaspartate (NAA) (Cho/NAA) and Cho to creatine (Cr) (Cho/Cr) correlated
highly with tumor malignancy. The presence of lactate and lipid was predominately detected in patients with high-grade glioma.
Conclusion: The combination of multiple MR parameters, based on DWI, PWI and 1 H-MRS, appears valuable for preoperatively predicting the degree of malignancy in glioma.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 17970039</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Brain Neoplasms - diagnosis ; Diffusion Magnetic Resonance Imaging ; Female ; Glioma - diagnosis ; Humans ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Middle Aged ; Neurology ; Protons ; Tumors ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Anticancer research, 2007-11, Vol.27 (6A), p.3757-3763</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,780,784,789,790,23929,23930,25139</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19197932$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17970039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>OSHIRO, Shinya</creatorcontrib><creatorcontrib>TSUGU, Hitoshi</creatorcontrib><creatorcontrib>KOMATSU, Fuminari</creatorcontrib><creatorcontrib>ABE, Hiroshi</creatorcontrib><creatorcontrib>ONISHI, Hirokazu</creatorcontrib><creatorcontrib>OHMURA, Tadahiro</creatorcontrib><creatorcontrib>IWAASA, Mitsutoshi</creatorcontrib><creatorcontrib>SAKAMOTO, Seisaburo</creatorcontrib><creatorcontrib>FUKUSHIMA, Takeo</creatorcontrib><title>Quantitative Assessment of Gliomas by Proton Magnetic Resonance Spectroscopy</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: Advanced magnetic resonance (MR) techniques provide physiological and metabolic information that complements the
anatomical information available from conventional MR imaging. The purpose of this study was to evaluate the clinical usefulness
of proton MR spectroscopy ( 1 H-MRS) in preoperative quantitative assessment of intracranial gliomas. Patients and Methods: Eight patients with histologically
verified gliomas, comprising 2 cases with glioblastoma multiforme (GBM, grade 4), 5 cases with anaplastic oligodendroglioma
(AO, grade 3; high-grade glioma), and 1 case with fibrillary astrocytoma (FA, grade 2; low-grade glioma) were evaluated using
the 1 H-MRS protocol following conventional MR imaging, diffusion-weighted imaging (DWI), and perfusion-weighted imaging (PWI) preoperatively.
Results: High-grade gliomas tended to demonstrate signal hyperintensity by DWI and higher relative cerebral blood volume (rCBV)
by PWI. Increased ratios of choline (Cho) to N-acetylaspartate (NAA) (Cho/NAA) and Cho to creatine (Cr) (Cho/Cr) correlated
highly with tumor malignancy. The presence of lactate and lipid was predominately detected in patients with high-grade glioma.
Conclusion: The combination of multiple MR parameters, based on DWI, PWI and 1 H-MRS, appears valuable for preoperatively predicting the degree of malignancy in glioma.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - diagnosis</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Female</subject><subject>Glioma - diagnosis</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Protons</subject><subject>Tumors</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFz01LxDAQBuAgiruu_gXJRW-FadM27XFZdBVW_D6HNEl3I21TM6nSf2_FlT0NDM-8w3tE5jEv44hnDI7JHJIMIg6QzcgZ4gdAnpcFOyWzCU1rVs7J5nmQXbBBBvtl6BLRILamC9TVdN1Y10qk1UifvAuuow9y25lgFX0x6DrZKUNfe6OCd6hcP56Tk1o2aC72c0Heb2_eVnfR5nF9v1puol3CIUSqKCHNK854xnNdxRwSxQrFeF1VkCa1kgCQKpPVUmmjQSesyrWOay2LYjpgC3L9l9t79zkYDKK1qEzTyM64AUVepBkULJ7g5R4OVWu06L1tpR_Ff_8JXO2BRCWb2k-dLB5cGZe8ZMnh485ud9_WG4GtbJoplgnpEy7ypfitw34AWHBy2A</recordid><startdate>20071101</startdate><enddate>20071101</enddate><creator>OSHIRO, Shinya</creator><creator>TSUGU, Hitoshi</creator><creator>KOMATSU, Fuminari</creator><creator>ABE, Hiroshi</creator><creator>ONISHI, Hirokazu</creator><creator>OHMURA, Tadahiro</creator><creator>IWAASA, Mitsutoshi</creator><creator>SAKAMOTO, Seisaburo</creator><creator>FUKUSHIMA, Takeo</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20071101</creationdate><title>Quantitative Assessment of Gliomas by Proton Magnetic Resonance Spectroscopy</title><author>OSHIRO, Shinya ; TSUGU, Hitoshi ; KOMATSU, Fuminari ; ABE, Hiroshi ; ONISHI, Hirokazu ; OHMURA, Tadahiro ; IWAASA, Mitsutoshi ; SAKAMOTO, Seisaburo ; FUKUSHIMA, Takeo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h270t-c89046b737576db1702c38c37fbb042fca0004ce5facded0d23b6dd1fda886db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - diagnosis</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Female</topic><topic>Glioma - diagnosis</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Protons</topic><topic>Tumors</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>OSHIRO, Shinya</creatorcontrib><creatorcontrib>TSUGU, Hitoshi</creatorcontrib><creatorcontrib>KOMATSU, Fuminari</creatorcontrib><creatorcontrib>ABE, Hiroshi</creatorcontrib><creatorcontrib>ONISHI, Hirokazu</creatorcontrib><creatorcontrib>OHMURA, Tadahiro</creatorcontrib><creatorcontrib>IWAASA, Mitsutoshi</creatorcontrib><creatorcontrib>SAKAMOTO, Seisaburo</creatorcontrib><creatorcontrib>FUKUSHIMA, Takeo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>OSHIRO, Shinya</au><au>TSUGU, Hitoshi</au><au>KOMATSU, Fuminari</au><au>ABE, Hiroshi</au><au>ONISHI, Hirokazu</au><au>OHMURA, Tadahiro</au><au>IWAASA, Mitsutoshi</au><au>SAKAMOTO, Seisaburo</au><au>FUKUSHIMA, Takeo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative Assessment of Gliomas by Proton Magnetic Resonance Spectroscopy</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2007-11-01</date><risdate>2007</risdate><volume>27</volume><issue>6A</issue><spage>3757</spage><epage>3763</epage><pages>3757-3763</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: Advanced magnetic resonance (MR) techniques provide physiological and metabolic information that complements the
anatomical information available from conventional MR imaging. The purpose of this study was to evaluate the clinical usefulness
of proton MR spectroscopy ( 1 H-MRS) in preoperative quantitative assessment of intracranial gliomas. Patients and Methods: Eight patients with histologically
verified gliomas, comprising 2 cases with glioblastoma multiforme (GBM, grade 4), 5 cases with anaplastic oligodendroglioma
(AO, grade 3; high-grade glioma), and 1 case with fibrillary astrocytoma (FA, grade 2; low-grade glioma) were evaluated using
the 1 H-MRS protocol following conventional MR imaging, diffusion-weighted imaging (DWI), and perfusion-weighted imaging (PWI) preoperatively.
Results: High-grade gliomas tended to demonstrate signal hyperintensity by DWI and higher relative cerebral blood volume (rCBV)
by PWI. Increased ratios of choline (Cho) to N-acetylaspartate (NAA) (Cho/NAA) and Cho to creatine (Cr) (Cho/Cr) correlated
highly with tumor malignancy. The presence of lactate and lipid was predominately detected in patients with high-grade glioma.
Conclusion: The combination of multiple MR parameters, based on DWI, PWI and 1 H-MRS, appears valuable for preoperatively predicting the degree of malignancy in glioma.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>17970039</pmid><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0250-7005 |
| ispartof | Anticancer research, 2007-11, Vol.27 (6A), p.3757-3763 |
| issn | 0250-7005 1791-7530 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68450831 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Biological and medical sciences Brain Neoplasms - diagnosis Diffusion Magnetic Resonance Imaging Female Glioma - diagnosis Humans Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Medical sciences Middle Aged Neurology Protons Tumors Tumors of the nervous system. Phacomatoses |
| title | Quantitative Assessment of Gliomas by Proton Magnetic Resonance Spectroscopy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T20%3A10%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Quantitative%20Assessment%20of%20Gliomas%20by%20Proton%20Magnetic%20Resonance%20Spectroscopy&rft.jtitle=Anticancer%20research&rft.au=OSHIRO,%20Shinya&rft.date=2007-11-01&rft.volume=27&rft.issue=6A&rft.spage=3757&rft.epage=3763&rft.pages=3757-3763&rft.issn=0250-7005&rft.eissn=1791-7530&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E68450831%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68450831&rft_id=info:pmid/17970039&rfr_iscdi=true |