Relationship between the Structure and the DNA Binding Properties of Diazoniapolycyclic Duplex- and Triplex-DNA Binders:  Efficiency, Selectivity, and Binding Mode

The association of dicationic polycyclic ligands, namely, four diazoniapentaphene derivatives, three diazoniaanthra[1,2-a]anthracenes, diazoniahexaphene, and a partly saturated hydroxy-substituted diazoniapentaphene with double-stranded and triple-helical DNA, was investigated by spectrophotometric...

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Veröffentlicht in:	Biochemistry (Easton) 2007-11, Vol.46 (44), p.12721-12736
Hauptverfasser:	Basili, Serena, Bergen, Anna, Dall'Acqua, Francesco, Faccio, Anita, Granzhan, Anton, Ihmels, Heiko, Moro, Stefano, Viola, Giampietro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrylates - pharmacokinetics Circular Dichroism Diazonium Compounds - chemistry Diazonium Compounds - pharmacokinetics DNA - metabolism Heterocyclic Compounds, 4 or More Rings - chemistry Heterocyclic Compounds, 4 or More Rings - pharmacokinetics Models, Biological Models, Molecular Polycyclic Compounds - chemistry Polycyclic Compounds - pharmacokinetics Structure-Activity Relationship Substrate Specificity Viscosity
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