Pharmacological nature of nicotine-induced contraction in the rat basilar artery: Involvement of arachidonic acid metabolites

The pharmacological nature of nicotine-induced contraction in the rat basilar artery is poorly understood. The purpose of this study was to investigate the endothelium dependency and involvement of arachidonic acid metabolites in nicotine-induced contraction in the rat basilar artery. The rat basila...

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Veröffentlicht in:	European journal of pharmacology 2007-12, Vol.577 (1), p.109-114
Hauptverfasser:	Ji, Xu, Nishihashi, Tsuyoshi, Trandafir, Cristina C., Wang, Aimin, Shimizu, Yoshiharu, Kurahashi, Kazuyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid - metabolism Arachidonic Acid - physiology Arachidonic acid metabolite Basilar Artery - drug effects Biological and medical sciences Contraction Cyclooxygenase 2 Inhibitors - pharmacology Cyclooxygenase Inhibitors - pharmacology Cyclooxygenase-2 (COX-2) Endothelium Endothelium, Vascular - physiology Enzyme Inhibitors - pharmacology In Vitro Techniques Lipoxygenase Inhibitors Medical sciences Muscle Contraction - drug effects Muscle, Smooth, Vascular - drug effects Nicotine Nicotine - pharmacology Nicotinic Agonists - pharmacology Pharmacology. Drug treatments Phospholipase A2 Inhibitors Rat basilar artery Rats Rats, Sprague-Dawley Saponins - pharmacology Type C Phospholipases - antagonists & inhibitors
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