Delivery of dendritic cells engineered to secrete IFN-alpha into central nervous system tumors enhances the efficacy of peripheral tumor cell vaccines: dependence on apoptotic pathways

We tested whether modulation of the CNS-tumor microenvironment by delivery of IFN-alpha-transduced dendritic cells (DCs: DC-IFN-alpha) would enhance the therapeutic efficacy of peripheral vaccinations with cytokine-gene transduced tumor cells. Mice bearing intracranial GL261 glioma or MCA205 sarcoma...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-08, Vol.175 (4), p.2730-2740
Hauptverfasser:	Kuwashima, Naruo, Nishimura, Fumihiko, Eguchi, Junichi, Sato, Hidemitsu, Hatano, Manabu, Tsugawa, Takahiko, Sakaida, Tsukasa, Dusak, Jill E, Fellows-Mayle, Wendy K, Papworth, Glenn D, Watkins, Simon C, Gambotto, Andrea, Pollack, Ian F, Storkus, Walter J, Okada, Hideho
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - genetics Adoptive Transfer Animals Antineoplastic Combined Chemotherapy Protocols - administration & dosage Apoptosis - immunology Brain Neoplasms - immunology Brain Neoplasms - pathology Brain Neoplasms - prevention & control Cancer Vaccines - administration & dosage Cancer Vaccines - genetics Cancer Vaccines - immunology Cell Line, Tumor Cytokines - biosynthesis Cytokines - physiology Cytokines - therapeutic use Cytotoxicity, Immunologic Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - transplantation Glioma - immunology Glioma - pathology Glioma - prevention & control Injections, Intralesional Injections, Intraventricular Interferon-alpha - administration & dosage Interferon-alpha - genetics Interferon-alpha - metabolism Lymph Nodes - immunology Lymph Nodes - pathology Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Signal Transduction - immunology Transduction, Genetic
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