Elevated expression of survivin-splice variants predicts a poor outcome for soft-tissue sarcomas patients

The aim of this study was to investigate the level and the prognostic value of the expression of different survivin transcript variants – survivin, survivin-ΔEx3 and survivin-2B – in tumours of 76 soft tissue sarcoma (STS) patients. The expression of survivin transcript variants in STS tissue sample...

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Veröffentlicht in:	Oncogene 2005-08, Vol.24 (33), p.5258-5261
Hauptverfasser:	Taubert, Helge, Kappler, Matthias, Bache, Matthias, Bartel, Frank, Köhler, Thomas, Lautenschläger, Christine, Blümke, Karen, Würl, Peter, Schmidt, Hannelore, Meye, Axel, Hauptmann, Steffen
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Apoptosis Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - biosynthesis Breast cancer Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Dermatology Female Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Human Genetics Humans Inhibitor of Apoptosis Proteins Internal Medicine Male Medical prognosis Medical sciences Medicine Medicine & Public Health Microtubule-Associated Proteins - analysis Microtubule-Associated Proteins - biosynthesis Molecular and cellular biology Neoplasm Proteins - analysis Neoplasm Proteins - biosynthesis Neoplasm Staging - methods Oncology Prognosis Protein Isoforms - analysis Protein Isoforms - biosynthesis Radiation therapy Reverse Transcriptase Polymerase Chain Reaction RNA Splice Sites RNA, Messenger - biosynthesis Sarcoma Sarcoma - genetics Sarcoma - mortality short-report Soft tissue sarcoma Survival Analysis Survivin Transcription Tumors Tumors of the skin and soft tissue. Premalignant lesions Urology
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