Elevated expression of survivin-splice variants predicts a poor outcome for soft-tissue sarcomas patients
The aim of this study was to investigate the level and the prognostic value of the expression of different survivin transcript variants – survivin, survivin-ΔEx3 and survivin-2B – in tumours of 76 soft tissue sarcoma (STS) patients. The expression of survivin transcript variants in STS tissue sample...
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| Veröffentlicht in: | Oncogene 2005-08, Vol.24 (33), p.5258-5261 |
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| creator | Taubert, Helge Kappler, Matthias Bache, Matthias Bartel, Frank Köhler, Thomas Lautenschläger, Christine Blümke, Karen Würl, Peter Schmidt, Hannelore Meye, Axel Hauptmann, Steffen |
| description | The aim of this study was to investigate the level and the prognostic value of the expression of different survivin transcript variants – survivin, survivin-ΔEx3 and survivin-2B – in tumours of 76 soft tissue sarcoma (STS) patients. The expression of survivin transcript variants in STS tissue samples and in 12 nonmalignant control tissues was analysed by quantitative RT–PCRs. Expression levels of all survivin transcript variants were strongly elevated in STS compared to normal tissues. A positive correlation between expression of splice variants and tumour stage was found (
P
=0.02;
χ
2
test). The multivariate Cox's proportional hazards regression model revealed a 7.3-fold increased risk of tumour-related death for patients with survivin-ΔEx3 overexpressing tumours (
P
=0.007). The effect of surivivin (wildtype variant) and survivin-2B was less pronounced but still significant (2.2- and 1.9-fold, resp.,
P |
| doi_str_mv | 10.1038/sj.onc.1208702 |
| format | Article |
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P
=0.02;
χ
2
test). The multivariate Cox's proportional hazards regression model revealed a 7.3-fold increased risk of tumour-related death for patients with survivin-ΔEx3 overexpressing tumours (
P
=0.007). The effect of surivivin (wildtype variant) and survivin-2B was less pronounced but still significant (2.2- and 1.9-fold, resp.,
P
<0.05 each). Our results show for the first time that mRNA expression of survivin-variants is significantly correlated to a poor prognosis for STS patients, and we suggest expression of survivin splice variants together with tumour stage as independent predictor of survival.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/sj.onc.1208702</identifier><identifier>PMID: 15856009</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Alternative splicing ; Apoptosis ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - biosynthesis ; Breast cancer ; Cell Biology ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Dermatology ; Female ; Fundamental and applied biological sciences. Psychology ; Gene expression ; Gene Expression Profiling ; Human Genetics ; Humans ; Inhibitor of Apoptosis Proteins ; Internal Medicine ; Male ; Medical prognosis ; Medical sciences ; Medicine ; Medicine & Public Health ; Microtubule-Associated Proteins - analysis ; Microtubule-Associated Proteins - biosynthesis ; Molecular and cellular biology ; Neoplasm Proteins - analysis ; Neoplasm Proteins - biosynthesis ; Neoplasm Staging - methods ; Oncology ; Prognosis ; Protein Isoforms - analysis ; Protein Isoforms - biosynthesis ; Radiation therapy ; Reverse Transcriptase Polymerase Chain Reaction ; RNA Splice Sites ; RNA, Messenger - biosynthesis ; Sarcoma ; Sarcoma - genetics ; Sarcoma - mortality ; short-report ; Soft tissue sarcoma ; Survival Analysis ; Survivin ; Transcription ; Tumors ; Tumors of the skin and soft tissue. Premalignant lesions ; Urology</subject><ispartof>Oncogene, 2005-08, Vol.24 (33), p.5258-5261</ispartof><rights>Springer Nature Limited 2005</rights><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Aug 4, 2005</rights><rights>Nature Publishing Group 2005.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c622t-e7786d9921b91bfd4454a5ff9677f8f10ac06c096a78265043e41944c40459393</citedby><cites>FETCH-LOGICAL-c622t-e7786d9921b91bfd4454a5ff9677f8f10ac06c096a78265043e41944c40459393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.onc.1208702$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.onc.1208702$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17016325$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15856009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taubert, Helge</creatorcontrib><creatorcontrib>Kappler, Matthias</creatorcontrib><creatorcontrib>Bache, Matthias</creatorcontrib><creatorcontrib>Bartel, Frank</creatorcontrib><creatorcontrib>Köhler, Thomas</creatorcontrib><creatorcontrib>Lautenschläger, Christine</creatorcontrib><creatorcontrib>Blümke, Karen</creatorcontrib><creatorcontrib>Würl, Peter</creatorcontrib><creatorcontrib>Schmidt, Hannelore</creatorcontrib><creatorcontrib>Meye, Axel</creatorcontrib><creatorcontrib>Hauptmann, Steffen</creatorcontrib><title>Elevated expression of survivin-splice variants predicts a poor outcome for soft-tissue sarcomas patients</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>The aim of this study was to investigate the level and the prognostic value of the expression of different survivin transcript variants – survivin, survivin-ΔEx3 and survivin-2B – in tumours of 76 soft tissue sarcoma (STS) patients. The expression of survivin transcript variants in STS tissue samples and in 12 nonmalignant control tissues was analysed by quantitative RT–PCRs. Expression levels of all survivin transcript variants were strongly elevated in STS compared to normal tissues. A positive correlation between expression of splice variants and tumour stage was found (
P
=0.02;
χ
2
test). The multivariate Cox's proportional hazards regression model revealed a 7.3-fold increased risk of tumour-related death for patients with survivin-ΔEx3 overexpressing tumours (
P
=0.007). The effect of surivivin (wildtype variant) and survivin-2B was less pronounced but still significant (2.2- and 1.9-fold, resp.,
P
<0.05 each). Our results show for the first time that mRNA expression of survivin-variants is significantly correlated to a poor prognosis for STS patients, and we suggest expression of survivin splice variants together with tumour stage as independent predictor of survival.</description><subject>Alternative splicing</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - biosynthesis</subject><subject>Breast cancer</subject><subject>Cell Biology</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Dermatology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Inhibitor of Apoptosis Proteins</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microtubule-Associated Proteins - analysis</subject><subject>Microtubule-Associated Proteins - biosynthesis</subject><subject>Molecular and cellular biology</subject><subject>Neoplasm Proteins - analysis</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Staging - methods</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Protein Isoforms - analysis</subject><subject>Protein Isoforms - biosynthesis</subject><subject>Radiation therapy</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA Splice Sites</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Sarcoma</subject><subject>Sarcoma - genetics</subject><subject>Sarcoma - mortality</subject><subject>short-report</subject><subject>Soft tissue sarcoma</subject><subject>Survival Analysis</subject><subject>Survivin</subject><subject>Transcription</subject><subject>Tumors</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><subject>Urology</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk2LFDEQhoMo7jh69SiNst56Nknn87gsuyoseNFzyKSTJUN30qa6B_33ZtiGAdlFckhR9bxVqfAi9J7gHcGduoLDLie3IxQriekLtCFMipZzzV6iDdYct5p29AK9AThgjKXG9DW6IFxxgbHeoHg7-KOdfd_431PxADGnJocGlnKMx5hamIbofHO0Jdo0Q1OhProa2GbKuTR5mV0efRNqDDnM7RwBFt-ALTVvq8DO0VflW_Qq2AH8u_Xeop93tz9uvrb33798u7m-b52gdG69lEr0WlOy12QfesY4szwELaQMKhBsHRYOa2GlooJj1nlGNGOOYcZ1p7st-vzYdyr51-JhNmME54fBJp8XMEIxphT9P0gkF4owUsFP_4CHvJRUlzBU1DrnrH7yFn18lqKy451k_NzqwQ7exBTyXKw7zTXXRGksBJesUrsnqHp6P0aXkw-x5p8SuJIBig9mKnG05Y8h2Jx8YuBgqk_M6pMq-LA-dtmPvj_jqzEqcLkCFpwdQrHJRThzEhPR0dNCV48c1FJ68OW89TOj_wLVmtPU</recordid><startdate>20050804</startdate><enddate>20050804</enddate><creator>Taubert, Helge</creator><creator>Kappler, Matthias</creator><creator>Bache, Matthias</creator><creator>Bartel, Frank</creator><creator>Köhler, Thomas</creator><creator>Lautenschläger, Christine</creator><creator>Blümke, Karen</creator><creator>Würl, Peter</creator><creator>Schmidt, Hannelore</creator><creator>Meye, Axel</creator><creator>Hauptmann, Steffen</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20050804</creationdate><title>Elevated expression of survivin-splice variants predicts a poor outcome for soft-tissue sarcomas patients</title><author>Taubert, Helge ; Kappler, Matthias ; Bache, Matthias ; Bartel, Frank ; Köhler, Thomas ; Lautenschläger, Christine ; Blümke, Karen ; Würl, Peter ; Schmidt, Hannelore ; Meye, Axel ; Hauptmann, Steffen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c622t-e7786d9921b91bfd4454a5ff9677f8f10ac06c096a78265043e41944c40459393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Alternative splicing</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - biosynthesis</topic><topic>Breast cancer</topic><topic>Cell Biology</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Dermatology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Inhibitor of Apoptosis Proteins</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microtubule-Associated Proteins - analysis</topic><topic>Microtubule-Associated Proteins - biosynthesis</topic><topic>Molecular and cellular biology</topic><topic>Neoplasm Proteins - analysis</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Neoplasm Staging - methods</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Protein Isoforms - analysis</topic><topic>Protein Isoforms - biosynthesis</topic><topic>Radiation therapy</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA Splice Sites</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Sarcoma</topic><topic>Sarcoma - genetics</topic><topic>Sarcoma - mortality</topic><topic>short-report</topic><topic>Soft tissue sarcoma</topic><topic>Survival Analysis</topic><topic>Survivin</topic><topic>Transcription</topic><topic>Tumors</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taubert, Helge</creatorcontrib><creatorcontrib>Kappler, Matthias</creatorcontrib><creatorcontrib>Bache, Matthias</creatorcontrib><creatorcontrib>Bartel, Frank</creatorcontrib><creatorcontrib>Köhler, Thomas</creatorcontrib><creatorcontrib>Lautenschläger, Christine</creatorcontrib><creatorcontrib>Blümke, Karen</creatorcontrib><creatorcontrib>Würl, Peter</creatorcontrib><creatorcontrib>Schmidt, Hannelore</creatorcontrib><creatorcontrib>Meye, Axel</creatorcontrib><creatorcontrib>Hauptmann, Steffen</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taubert, Helge</au><au>Kappler, Matthias</au><au>Bache, Matthias</au><au>Bartel, Frank</au><au>Köhler, Thomas</au><au>Lautenschläger, Christine</au><au>Blümke, Karen</au><au>Würl, Peter</au><au>Schmidt, Hannelore</au><au>Meye, Axel</au><au>Hauptmann, Steffen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated expression of survivin-splice variants predicts a poor outcome for soft-tissue sarcomas patients</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2005-08-04</date><risdate>2005</risdate><volume>24</volume><issue>33</issue><spage>5258</spage><epage>5261</epage><pages>5258-5261</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>The aim of this study was to investigate the level and the prognostic value of the expression of different survivin transcript variants – survivin, survivin-ΔEx3 and survivin-2B – in tumours of 76 soft tissue sarcoma (STS) patients. The expression of survivin transcript variants in STS tissue samples and in 12 nonmalignant control tissues was analysed by quantitative RT–PCRs. Expression levels of all survivin transcript variants were strongly elevated in STS compared to normal tissues. A positive correlation between expression of splice variants and tumour stage was found (
P
=0.02;
χ
2
test). The multivariate Cox's proportional hazards regression model revealed a 7.3-fold increased risk of tumour-related death for patients with survivin-ΔEx3 overexpressing tumours (
P
=0.007). The effect of surivivin (wildtype variant) and survivin-2B was less pronounced but still significant (2.2- and 1.9-fold, resp.,
P
<0.05 each). Our results show for the first time that mRNA expression of survivin-variants is significantly correlated to a poor prognosis for STS patients, and we suggest expression of survivin splice variants together with tumour stage as independent predictor of survival.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>15856009</pmid><doi>10.1038/sj.onc.1208702</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Oncogene, 2005-08, Vol.24 (33), p.5258-5261 |
| issn | 0950-9232 1476-5594 |
| language | eng |
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| source | MEDLINE; Nature Journals Online; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Alternative splicing Apoptosis Biological and medical sciences Biomarkers, Tumor - analysis Biomarkers, Tumor - biosynthesis Breast cancer Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Dermatology Female Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Human Genetics Humans Inhibitor of Apoptosis Proteins Internal Medicine Male Medical prognosis Medical sciences Medicine Medicine & Public Health Microtubule-Associated Proteins - analysis Microtubule-Associated Proteins - biosynthesis Molecular and cellular biology Neoplasm Proteins - analysis Neoplasm Proteins - biosynthesis Neoplasm Staging - methods Oncology Prognosis Protein Isoforms - analysis Protein Isoforms - biosynthesis Radiation therapy Reverse Transcriptase Polymerase Chain Reaction RNA Splice Sites RNA, Messenger - biosynthesis Sarcoma Sarcoma - genetics Sarcoma - mortality short-report Soft tissue sarcoma Survival Analysis Survivin Transcription Tumors Tumors of the skin and soft tissue. Premalignant lesions Urology |
| title | Elevated expression of survivin-splice variants predicts a poor outcome for soft-tissue sarcomas patients |
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