Cigarette Smoke Extract Suppresses Human Dendritic Cell Function Leading to Preferential Induction of Th-2 Priming

Dendritic cells (DC) are key regulators of immune responses. In the current study, we hypothesized that cigarette smoke-induced aberrance in DC function is an important mechanism by which smokers develop cancer, infection, and allergy--diseases common in smokers. We demonstrate that cigarette smoke...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-08, Vol.175 (4), p.2684-2691
Hauptverfasser:	Vassallo, Robert, Tamada, Koji, Lau, Julie S, Kroening, Paula R, Chen, Lieping
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Cell Death - immunology Cell Differentiation - immunology Cell Proliferation - drug effects Cells, Cultured Cyclooxygenase 2 - biosynthesis Cyclooxygenase 2 - physiology Cytokines - antagonists & inhibitors Cytokines - biosynthesis Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Dinoprostone - metabolism Down-Regulation - immunology Growth Inhibitors - pharmacology Humans Immunophenotyping Immunosuppressive Agents Interleukin-10 - metabolism Interleukin-12 - antagonists & inhibitors Interleukin-12 - metabolism Lipopolysaccharides - immunology Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Nicotine Receptors, Chemokine - antagonists & inhibitors Receptors, Chemokine - biosynthesis Receptors, Chemokine - physiology Smoke T-Lymphocytes - cytology T-Lymphocytes - immunology T-Lymphocytes - metabolism Th2 Cells - cytology Th2 Cells - immunology Th2 Cells - metabolism Up-Regulation - immunology
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