Escape from microenvironmental control and progression of intraepithelial neoplasia

We previously reported that normal human keratinocytes controlled neoplastic progression of tumor cells at an early stage of transformation in stratified squamous epithelium. We now studied if cells at a more advanced stage of transformation were also subject to such microenvironmental control. To a...

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Veröffentlicht in:	International journal of cancer 2005-10, Vol.116 (6), p.885-893
Hauptverfasser:	Zhang, Weitian, Vaccariello, Michael A., Wang, Youai, Alt‐Holland, Addy, Fusenig, Norbert E., Garlick, Jonathan A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cells, Cultured cell–cell interactions Disease Progression Epithelial Cells - cytology Epithelial Cells - pathology General aspects Humans Infant, Newborn intraepithelial neoplasia keratinocyte Keratinocytes - cytology Keratinocytes - pathology Male Medical sciences Mice Mice, Nude Moloney murine leukemia virus Neoplasm Staging organotypic culture Skin Neoplasms - pathology Skin Neoplasms - prevention & control transformation Transplantation, Heterologous tumor microenvironment Tumors
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