Are Factor V and Prothrombin Mutations Associated with Increased Risk of Oral Cancer?
Background: Methylenetetrahydrofolate reductase is associated with pathogenesis of both thrombosis and oral cancer. Therefore, a search for a similar association of other thrombosis-related factors with oral cancer is justified. Patients and Methods: In order to investigate whether the coagulation f...
Gespeichert in:
| Veröffentlicht in: | Anticancer research 2005-05, Vol.25 (3C), p.2561-2565 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2565 |
|---|---|
| container_issue | 3C |
| container_start_page | 2561 |
| container_title | Anticancer research |
| container_volume | 25 |
| creator | VAIRAKTARIS, Eleftherios YAPIJAKIS, Christos WILTFANG, Jörg RIES, Jutta VYLLIOTIS, Antonis DERKA, Spyridoula VASILIOU, Stavros NEUKAM, Friedrich W |
| description | Background: Methylenetetrahydrofolate reductase is associated with pathogenesis of both thrombosis and oral cancer. Therefore,
a search for a similar association of other thrombosis-related factors with oral cancer is justified. Patients and Methods:
In order to investigate whether the coagulation factor V Leiden and prothrombin G20210A mutations increase the risk of oral
cancer, we searched for these mutant alleles by RFLP analysis in DNA samples of 102 patients with oral cancer and 120 healthy
controls. Results: Neither the Leiden nor the G20210A alleles were found in statistically different frequencies in the two
groups. In addition, no statistical difference was observed in parameters such as sex, age and positive family history for
cancer. Nevertheless, a significant difference was observed for Leiden in patients with a positive history for thrombophilia
(p |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_68447584</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68447584</sourcerecordid><originalsourceid>FETCH-LOGICAL-h301t-39afe35bac3394d873550dbf2504cb36609ae86b32a12e6cad5aaa3461e64f2b3</originalsourceid><addsrcrecordid>eNqFkF1LwzAUhoMobk7_guRG7wpJ89HmSsZwOphMxHlbTtPURttmJi3Df2_Aid55dTjw8D7nvEdoSjNFk0wwcoymJBUkyQgRE3QWwhshUqqcnaIJlSQnXLEp2s69wUvQg_P4BUNf4Ufvhsa7rrQ9fhgHGKzrA56H4LSFwVR4b4cGr3rtDYS4Ptnwjl2NNx5avIBeG39zjk5qaIO5OMwZ2i5vnxf3yXpzt1rM10nDCB0SpqA2TJSgGVO8yjMmBKnKOp7NdcmkJApMLkuWAk2N1FAJAGBcUiN5nZZshq6_c3fefYwmDEVngzZtC71xYyhkznkmcv4vSKOaS0kjeHkAx7IzVbHztgP_Wfw0FoGrAwBBQ1v7-LENfziVSa7or7Gxr83eelOEDto2xrICfCoKtihSEY1fy9eBRA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17354661</pqid></control><display><type>article</type><title>Are Factor V and Prothrombin Mutations Associated with Increased Risk of Oral Cancer?</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>VAIRAKTARIS, Eleftherios ; YAPIJAKIS, Christos ; WILTFANG, Jörg ; RIES, Jutta ; VYLLIOTIS, Antonis ; DERKA, Spyridoula ; VASILIOU, Stavros ; NEUKAM, Friedrich W</creator><creatorcontrib>VAIRAKTARIS, Eleftherios ; YAPIJAKIS, Christos ; WILTFANG, Jörg ; RIES, Jutta ; VYLLIOTIS, Antonis ; DERKA, Spyridoula ; VASILIOU, Stavros ; NEUKAM, Friedrich W</creatorcontrib><description>Background: Methylenetetrahydrofolate reductase is associated with pathogenesis of both thrombosis and oral cancer. Therefore,
a search for a similar association of other thrombosis-related factors with oral cancer is justified. Patients and Methods:
In order to investigate whether the coagulation factor V Leiden and prothrombin G20210A mutations increase the risk of oral
cancer, we searched for these mutant alleles by RFLP analysis in DNA samples of 102 patients with oral cancer and 120 healthy
controls. Results: Neither the Leiden nor the G20210A alleles were found in statistically different frequencies in the two
groups. In addition, no statistical difference was observed in parameters such as sex, age and positive family history for
cancer. Nevertheless, a significant difference was observed for Leiden in patients with a positive history for thrombophilia
(p<0.001). Conclusion: There seems to be no association of prothrombin, and possibly a minor contribution of factor V, in
oncogenesis in the oral region.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 16080493</identifier><language>eng</language><publisher>Attiki: International Institute of Anticancer Research</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alleles ; Biological and medical sciences ; Carcinoma, Squamous Cell - blood ; Carcinoma, Squamous Cell - genetics ; Factor V - genetics ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Mouth Neoplasms - blood ; Mouth Neoplasms - genetics ; Mutation ; Otorhinolaryngology. Stomatology ; Polymorphism, Restriction Fragment Length ; Prothrombin - genetics ; Thrombophilia - blood ; Thrombophilia - genetics ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Anticancer research, 2005-05, Vol.25 (3C), p.2561-2565</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16976491$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16080493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAIRAKTARIS, Eleftherios</creatorcontrib><creatorcontrib>YAPIJAKIS, Christos</creatorcontrib><creatorcontrib>WILTFANG, Jörg</creatorcontrib><creatorcontrib>RIES, Jutta</creatorcontrib><creatorcontrib>VYLLIOTIS, Antonis</creatorcontrib><creatorcontrib>DERKA, Spyridoula</creatorcontrib><creatorcontrib>VASILIOU, Stavros</creatorcontrib><creatorcontrib>NEUKAM, Friedrich W</creatorcontrib><title>Are Factor V and Prothrombin Mutations Associated with Increased Risk of Oral Cancer?</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Background: Methylenetetrahydrofolate reductase is associated with pathogenesis of both thrombosis and oral cancer. Therefore,
a search for a similar association of other thrombosis-related factors with oral cancer is justified. Patients and Methods:
In order to investigate whether the coagulation factor V Leiden and prothrombin G20210A mutations increase the risk of oral
cancer, we searched for these mutant alleles by RFLP analysis in DNA samples of 102 patients with oral cancer and 120 healthy
controls. Results: Neither the Leiden nor the G20210A alleles were found in statistically different frequencies in the two
groups. In addition, no statistical difference was observed in parameters such as sex, age and positive family history for
cancer. Nevertheless, a significant difference was observed for Leiden in patients with a positive history for thrombophilia
(p<0.001). Conclusion: There seems to be no association of prothrombin, and possibly a minor contribution of factor V, in
oncogenesis in the oral region.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - blood</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Factor V - genetics</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - blood</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mutation</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Prothrombin - genetics</subject><subject>Thrombophilia - blood</subject><subject>Thrombophilia - genetics</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1LwzAUhoMobk7_guRG7wpJ89HmSsZwOphMxHlbTtPURttmJi3Df2_Aid55dTjw8D7nvEdoSjNFk0wwcoymJBUkyQgRE3QWwhshUqqcnaIJlSQnXLEp2s69wUvQg_P4BUNf4Ufvhsa7rrQ9fhgHGKzrA56H4LSFwVR4b4cGr3rtDYS4Ptnwjl2NNx5avIBeG39zjk5qaIO5OMwZ2i5vnxf3yXpzt1rM10nDCB0SpqA2TJSgGVO8yjMmBKnKOp7NdcmkJApMLkuWAk2N1FAJAGBcUiN5nZZshq6_c3fefYwmDEVngzZtC71xYyhkznkmcv4vSKOaS0kjeHkAx7IzVbHztgP_Wfw0FoGrAwBBQ1v7-LENfziVSa7or7Gxr83eelOEDto2xrICfCoKtihSEY1fy9eBRA</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>VAIRAKTARIS, Eleftherios</creator><creator>YAPIJAKIS, Christos</creator><creator>WILTFANG, Jörg</creator><creator>RIES, Jutta</creator><creator>VYLLIOTIS, Antonis</creator><creator>DERKA, Spyridoula</creator><creator>VASILIOU, Stavros</creator><creator>NEUKAM, Friedrich W</creator><general>International Institute of Anticancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20050501</creationdate><title>Are Factor V and Prothrombin Mutations Associated with Increased Risk of Oral Cancer?</title><author>VAIRAKTARIS, Eleftherios ; YAPIJAKIS, Christos ; WILTFANG, Jörg ; RIES, Jutta ; VYLLIOTIS, Antonis ; DERKA, Spyridoula ; VASILIOU, Stavros ; NEUKAM, Friedrich W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h301t-39afe35bac3394d873550dbf2504cb36609ae86b32a12e6cad5aaa3461e64f2b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - blood</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Factor V - genetics</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - blood</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mutation</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Prothrombin - genetics</topic><topic>Thrombophilia - blood</topic><topic>Thrombophilia - genetics</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAIRAKTARIS, Eleftherios</creatorcontrib><creatorcontrib>YAPIJAKIS, Christos</creatorcontrib><creatorcontrib>WILTFANG, Jörg</creatorcontrib><creatorcontrib>RIES, Jutta</creatorcontrib><creatorcontrib>VYLLIOTIS, Antonis</creatorcontrib><creatorcontrib>DERKA, Spyridoula</creatorcontrib><creatorcontrib>VASILIOU, Stavros</creatorcontrib><creatorcontrib>NEUKAM, Friedrich W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAIRAKTARIS, Eleftherios</au><au>YAPIJAKIS, Christos</au><au>WILTFANG, Jörg</au><au>RIES, Jutta</au><au>VYLLIOTIS, Antonis</au><au>DERKA, Spyridoula</au><au>VASILIOU, Stavros</au><au>NEUKAM, Friedrich W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are Factor V and Prothrombin Mutations Associated with Increased Risk of Oral Cancer?</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>25</volume><issue>3C</issue><spage>2561</spage><epage>2565</epage><pages>2561-2565</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Background: Methylenetetrahydrofolate reductase is associated with pathogenesis of both thrombosis and oral cancer. Therefore,
a search for a similar association of other thrombosis-related factors with oral cancer is justified. Patients and Methods:
In order to investigate whether the coagulation factor V Leiden and prothrombin G20210A mutations increase the risk of oral
cancer, we searched for these mutant alleles by RFLP analysis in DNA samples of 102 patients with oral cancer and 120 healthy
controls. Results: Neither the Leiden nor the G20210A alleles were found in statistically different frequencies in the two
groups. In addition, no statistical difference was observed in parameters such as sex, age and positive family history for
cancer. Nevertheless, a significant difference was observed for Leiden in patients with a positive history for thrombophilia
(p<0.001). Conclusion: There seems to be no association of prothrombin, and possibly a minor contribution of factor V, in
oncogenesis in the oral region.</abstract><cop>Attiki</cop><pub>International Institute of Anticancer Research</pub><pmid>16080493</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0250-7005 |
| ispartof | Anticancer research, 2005-05, Vol.25 (3C), p.2561-2565 |
| issn | 0250-7005 1791-7530 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68447584 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Aged, 80 and over Alleles Biological and medical sciences Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - genetics Factor V - genetics Female Humans Male Medical sciences Middle Aged Mouth Neoplasms - blood Mouth Neoplasms - genetics Mutation Otorhinolaryngology. Stomatology Polymorphism, Restriction Fragment Length Prothrombin - genetics Thrombophilia - blood Thrombophilia - genetics Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Are Factor V and Prothrombin Mutations Associated with Increased Risk of Oral Cancer? |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T05%3A32%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Are%20Factor%20V%20and%20Prothrombin%20Mutations%20Associated%20with%20Increased%20Risk%20of%20Oral%20Cancer?&rft.jtitle=Anticancer%20research&rft.au=VAIRAKTARIS,%20Eleftherios&rft.date=2005-05-01&rft.volume=25&rft.issue=3C&rft.spage=2561&rft.epage=2565&rft.pages=2561-2565&rft.issn=0250-7005&rft.eissn=1791-7530&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E68447584%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17354661&rft_id=info:pmid/16080493&rfr_iscdi=true |