Role of MAPK Phosphatase-1 in Sustained Activation of JNK during Ethanol-induced Apoptosis in Hepatocyte-like VL-17A Cells

Ethanol metabolism plays a central role in activating the mitogen-activated protein kinase (MAPK) cascade leading to inflammation and apoptosis. Sustained activation of c-Jun N-terminal kinase (JNK), one of the MAPKs, has been shown to induce apoptosis in hepatocytes. MAPK phosphatase-1 (MKP-1) has...

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Veröffentlicht in:	The Journal of biological chemistry 2007-11, Vol.282 (44), p.31900-31908
Hauptverfasser:	Venugopal, Senthil K., Chen, Jenny, Zhang, Yanhong, Clemens, Dahn, Follenzi, Antonia, Zern, Mark A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Cell Line, Tumor Dual Specificity Phosphatase 1 - metabolism Ethanol - pharmacology Hepatocytes - cytology Humans JNK Mitogen-Activated Protein Kinases - metabolism Protein Kinase C-delta - metabolism
Online-Zugang:	Volltext
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