A safety and feasibility report of combined direct thrombin and GP IIb/IIIa inhibition with bivalirudin and tirofiban in peripheral vascular disease intervention: treating critical limb ischemia like acute coronary syndrome

The combination of glycoprotein (GP) IIb-IIIa inhibition and direct thrombin inhibition (DTI) with bivalirudin (Angiomax, The Medicines Company, Cambridge, Massachusetts) have shown ischemic and hemorrhagic outcomes benefit in coronary interventions and may have similar benefits in percutaneous peri...

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Veröffentlicht in:	The Journal of invasive cardiology 2005-08, Vol.17 (8), p.427-432
Hauptverfasser:	Allie, David E, Hebert, Chris J, Lirtzman, Mitchell D, Wyatt, Charles H, Keller, V Antoine, Khan, Mohamed H, Khan, Muhammad A, Fail, Peter S, Vivekananthan, Krishnamoorthy, Allie, Sonja E, Mitran, Elena V, Chaisson, Gary, Stagg, 3rd, Samuel J, Allie, Adam A, McElderry, Michael W, Barker, Esmond A, Walker, Craig M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Aged Angioplasty, Balloon Anticoagulants - adverse effects Anticoagulants - therapeutic use Feasibility Studies Female Follow-Up Studies Hirudins Humans Ischemia - blood Ischemia - therapy Leg - blood supply Male Myocardial Ischemia - blood Myocardial Ischemia - therapy Peptide Fragments - therapeutic use Peripheral Vascular Diseases - blood Peripheral Vascular Diseases - therapy Platelet Aggregation Inhibitors - therapeutic use Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Recombinant Proteins - therapeutic use Retrospective Studies Thrombin - antagonists & inhibitors Thrombin - metabolism Treatment Outcome Tyrosine - analogs & derivatives Tyrosine - therapeutic use
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