Effect of Pore Size of FSM-16 on the Entrapment of Flurbiprofen in Mesoporous Structures

The interaction between FSM-16 and flurbiprofen (FBP) in the mesopores of FSM-16 was investigated by using three types of FSM-16 with different pore diameters, i.e., FSM-16(Oc), FSM-16(Do) and FSM-16(Doc) (pore diameters 16.0, 21.6, 45.0 Å, respectively). Solid dispersions of 30% FBP–70% FSM-16 were...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2005, Vol.53(8), pp.974-977
Hauptverfasser:	Tozuka, Yuichi, Wongmekiat, Arpansiree, Kimura, Kyoko, Moribe, Kunikazu, Yamamura, Shigeo, Yamamoto, Keiji
Format:	Artikel
Sprache:	eng
Schlagworte:	amorphous Anti-Inflammatory Agents, Non-Steroidal - chemistry Calorimetry, Differential Scanning dissolution Drug Carriers flurbiprofen Flurbiprofen - chemistry FSM-16 porous material Silicon Dioxide - chemistry small angle X-ray scattering Spectroscopy, Fourier Transform Infrared X-Ray Diffraction
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