Smart "Turn-on" Magnetic Resonance Contrast Agents Based on Aptamer-Functionalized Superparamagnetic Iron Oxide Nanoparticles

Smart agents. A contrast agent was designed by combining target specific nucleic‐acid aptamers against adenosine with superparamagnetic iron oxide nanoparticles. Target‐induced disassembly of clustered nanoparticles in the presence of adenosine led to an increase in T2, which was seen as an increase...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2007-09, Vol.8 (14), p.1675-1678
Hauptverfasser:	Yigit, Mehmet Veysel, Mazumdar, Debapriya, Kim, Hee-Kyung, Lee, Jung Heon, Odintsov, Boris, Lu, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine aptamers Base Sequence Biochemistry - methods Contrast Media - pharmacology DNA - chemistry Ferric Compounds - chemistry Ferric Compounds - pharmacology imaging agents Light magnetic resonance imaging Magnetic Resonance Imaging - instrumentation Magnetic Resonance Imaging - methods Magnetics Metal Nanoparticles - chemistry Molecular Sequence Data Mutation nanostructures Nanotechnology - methods RNA - chemistry Scattering, Radiation
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Beschreibung
Zusammenfassung:	Smart agents. A contrast agent was designed by combining target specific nucleic‐acid aptamers against adenosine with superparamagnetic iron oxide nanoparticles. Target‐induced disassembly of clustered nanoparticles in the presence of adenosine led to an increase in T2, which was seen as an increase in the brightness of the magnetic resonance image (see figure).
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.200700323