A transforming growth factor-β receptor-interacting protein frequently mutated in human ovarian cancer

Ovarian carcinomas, particularly recurrent forms, are frequently resistant to transforming growth factor-beta (TGF-beta)-mediated growth inhibition. However, mutations in the TGF-beta receptor I and receptor II (TbetaR-I and TbetaR-II) genes have only been reported in a minority of ovarian carcinoma...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-08, Vol.65 (15), p.6526-6533
Hauptverfasser:	WEI DING, QIAN TANG, ESPINA, Virginia, LIOTTA, Lance A, MAUGER, David T, MULDER, Kathleen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amino Acid Sequence Animals Base Sequence Biological and medical sciences Carrier Proteins - genetics Drosophila Proteins - genetics Dyneins Exons - genetics Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Molecular Sequence Data Mutation, Missense Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Receptors, Transforming Growth Factor beta - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction Tumors
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