The Ansacarbamitocins: Polar Ansamitocin Derivatives
The ansacarbamitocins are a new family of maytansinoids that are unusually substituted with a glucose subunit and two carbamate functional groups and exhibit modest activity against some agricultural fungal disease organisms. Ansacarbamitocins A–F (1–6) all consist of the same macrocyclic core as th...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2007-10, Vol.70 (10), p.1578-1581 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Snipes, Carl E Duebelbeis, Dennis O Olson, Monica Hahn, Donald R Dent, William H Gilbert, Jeffrey R Werk, Todd L Davis, George E Lee-Lu, Rebecca Graupner, Paul R |
| description | The ansacarbamitocins are a new family of maytansinoids that are unusually substituted with a glucose subunit and two carbamate functional groups and exhibit modest activity against some agricultural fungal disease organisms. Ansacarbamitocins A–F (1–6) all consist of the same macrocyclic core as the ansamitocins, with variation occurring on the glucose unit, while ansacarbamitocins A1 and B1 (7, 8) additionally lack the epoxide group on C-4 and C-5. |
| doi_str_mv | 10.1021/np070275t |
| format | Article |
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Ansacarbamitocins A–F (1–6) all consist of the same macrocyclic core as the ansamitocins, with variation occurring on the glucose unit, while ansacarbamitocins A1 and B1 (7, 8) additionally lack the epoxide group on C-4 and C-5.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np070275t</identifier><identifier>PMID: 17892263</identifier><identifier>CODEN: JNPRDF</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Actinomycetales - chemistry ; Amycolatopsis ; ansacarbamitocin ; ansamitocin ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - classification ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; antifungal properties ; Ascomycota - drug effects ; Biological and medical sciences ; chemical structure ; Control ; Erysiphe graminis ; Fundamental and applied biological sciences. Psychology ; fungal diseases of plants ; Fungal plant pathogens ; lactams ; macrolides ; Maytansine - analogs & derivatives ; Maytansine - chemistry ; Maytansine - classification ; Maytansine - isolation & purification ; Maytansine - pharmacology ; Molecular Structure ; Mycosphaerella graminicola ; Phytopathology. Animal pests. Plant and forest protection ; plant pathogenic fungi ; Puccinia recondita ; soil bacteria ; spectral analysis ; Structure-Activity Relationship</subject><ispartof>Journal of natural products (Washington, D.C.), 2007-10, Vol.70 (10), p.1578-1581</ispartof><rights>Copyright © 2007 American Chemical Society and American Society of Pharmacognosy and STD NP</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a405t-f4ec2ffb812ecb9e84c373332cb09e90b340d92d6468b681f91f3c558af354a3</citedby><cites>FETCH-LOGICAL-a405t-f4ec2ffb812ecb9e84c373332cb09e90b340d92d6468b681f91f3c558af354a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np070275t$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np070275t$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19211026$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17892263$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Snipes, Carl E</creatorcontrib><creatorcontrib>Duebelbeis, Dennis O</creatorcontrib><creatorcontrib>Olson, Monica</creatorcontrib><creatorcontrib>Hahn, Donald R</creatorcontrib><creatorcontrib>Dent, William H</creatorcontrib><creatorcontrib>Gilbert, Jeffrey R</creatorcontrib><creatorcontrib>Werk, Todd L</creatorcontrib><creatorcontrib>Davis, George E</creatorcontrib><creatorcontrib>Lee-Lu, Rebecca</creatorcontrib><creatorcontrib>Graupner, Paul R</creatorcontrib><title>The Ansacarbamitocins: Polar Ansamitocin Derivatives</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>The ansacarbamitocins are a new family of maytansinoids that are unusually substituted with a glucose subunit and two carbamate functional groups and exhibit modest activity against some agricultural fungal disease organisms. 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Psychology</subject><subject>fungal diseases of plants</subject><subject>Fungal plant pathogens</subject><subject>lactams</subject><subject>macrolides</subject><subject>Maytansine - analogs & derivatives</subject><subject>Maytansine - chemistry</subject><subject>Maytansine - classification</subject><subject>Maytansine - isolation & purification</subject><subject>Maytansine - pharmacology</subject><subject>Molecular Structure</subject><subject>Mycosphaerella graminicola</subject><subject>Phytopathology. Animal pests. Plant and forest protection</subject><subject>plant pathogenic fungi</subject><subject>Puccinia recondita</subject><subject>soil bacteria</subject><subject>spectral analysis</subject><subject>Structure-Activity Relationship</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0MtOwzAQBVALgaA8FvwAdAMSi8D4GYddKU8JCaSWtTVxbQikSbETBH9PoBHdsLLkObr2XEL2KZxSYPSsWkAKLJXNGhlQySBRwOQ6GQBVPOFaiS2yHeMrAHDI5CbZoqnOGFN8QMT0xQ1HVUSLIcd50dS2qOL58LEuMfwO-rvhpQvFBzbFh4u7ZMNjGd1ef-6Q6fXVdHyb3D_c3I1H9wkKkE3ihbPM-1xT5myeOS0sTznnzOaQuQxyLmCWsZkSSudKU59Rz62UGj2XAvkOOV7GLkL93rrYmHkRrStLrFzdRqO0EMBAd_BkCW2oYwzOm0Uo5hi-DAXz05D5a6izB31om8_dbCX7Sjpw1AOMFksfsLJFXLmM0S5SdS5ZuiI27vNvjuHNqJSn0kwfJ0YJOblUF9L8fPJw6T3WBp9Dl_k0YUA5gNYMuFi9jDaa17oNVVfuPyt8A77HkKg</recordid><startdate>20071001</startdate><enddate>20071001</enddate><creator>Snipes, Carl E</creator><creator>Duebelbeis, Dennis O</creator><creator>Olson, Monica</creator><creator>Hahn, Donald R</creator><creator>Dent, William H</creator><creator>Gilbert, Jeffrey R</creator><creator>Werk, Todd L</creator><creator>Davis, George E</creator><creator>Lee-Lu, Rebecca</creator><creator>Graupner, Paul R</creator><general>American Chemical Society</general><general>American Society of Pharmacognosy</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20071001</creationdate><title>The Ansacarbamitocins: Polar Ansamitocin Derivatives</title><author>Snipes, Carl E ; Duebelbeis, Dennis O ; Olson, Monica ; Hahn, Donald R ; Dent, William H ; Gilbert, Jeffrey R ; Werk, Todd L ; Davis, George E ; Lee-Lu, Rebecca ; Graupner, Paul R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a405t-f4ec2ffb812ecb9e84c373332cb09e90b340d92d6468b681f91f3c558af354a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Actinomycetales - chemistry</topic><topic>Amycolatopsis</topic><topic>ansacarbamitocin</topic><topic>ansamitocin</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - classification</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>antifungal properties</topic><topic>Ascomycota - drug effects</topic><topic>Biological and medical sciences</topic><topic>chemical structure</topic><topic>Control</topic><topic>Erysiphe graminis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>fungal diseases of plants</topic><topic>Fungal plant pathogens</topic><topic>lactams</topic><topic>macrolides</topic><topic>Maytansine - analogs & derivatives</topic><topic>Maytansine - chemistry</topic><topic>Maytansine - classification</topic><topic>Maytansine - isolation & purification</topic><topic>Maytansine - pharmacology</topic><topic>Molecular Structure</topic><topic>Mycosphaerella graminicola</topic><topic>Phytopathology. Animal pests. Plant and forest protection</topic><topic>plant pathogenic fungi</topic><topic>Puccinia recondita</topic><topic>soil bacteria</topic><topic>spectral analysis</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Snipes, Carl E</creatorcontrib><creatorcontrib>Duebelbeis, Dennis O</creatorcontrib><creatorcontrib>Olson, Monica</creatorcontrib><creatorcontrib>Hahn, Donald R</creatorcontrib><creatorcontrib>Dent, William H</creatorcontrib><creatorcontrib>Gilbert, Jeffrey R</creatorcontrib><creatorcontrib>Werk, Todd L</creatorcontrib><creatorcontrib>Davis, George E</creatorcontrib><creatorcontrib>Lee-Lu, Rebecca</creatorcontrib><creatorcontrib>Graupner, Paul R</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Snipes, Carl E</au><au>Duebelbeis, Dennis O</au><au>Olson, Monica</au><au>Hahn, Donald R</au><au>Dent, William H</au><au>Gilbert, Jeffrey R</au><au>Werk, Todd L</au><au>Davis, George E</au><au>Lee-Lu, Rebecca</au><au>Graupner, Paul R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Ansacarbamitocins: Polar Ansamitocin Derivatives</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2007-10-01</date><risdate>2007</risdate><volume>70</volume><issue>10</issue><spage>1578</spage><epage>1581</epage><pages>1578-1581</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><coden>JNPRDF</coden><abstract>The ansacarbamitocins are a new family of maytansinoids that are unusually substituted with a glucose subunit and two carbamate functional groups and exhibit modest activity against some agricultural fungal disease organisms. Ansacarbamitocins A–F (1–6) all consist of the same macrocyclic core as the ansamitocins, with variation occurring on the glucose unit, while ansacarbamitocins A1 and B1 (7, 8) additionally lack the epoxide group on C-4 and C-5.</abstract><cop>Washington, DC</cop><cop>Glendale, AZ</cop><pub>American Chemical Society</pub><pmid>17892263</pmid><doi>10.1021/np070275t</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of natural products (Washington, D.C.), 2007-10, Vol.70 (10), p.1578-1581 |
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| subjects | Actinomycetales - chemistry Amycolatopsis ansacarbamitocin ansamitocin Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - classification Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology antifungal properties Ascomycota - drug effects Biological and medical sciences chemical structure Control Erysiphe graminis Fundamental and applied biological sciences. Psychology fungal diseases of plants Fungal plant pathogens lactams macrolides Maytansine - analogs & derivatives Maytansine - chemistry Maytansine - classification Maytansine - isolation & purification Maytansine - pharmacology Molecular Structure Mycosphaerella graminicola Phytopathology. Animal pests. Plant and forest protection plant pathogenic fungi Puccinia recondita soil bacteria spectral analysis Structure-Activity Relationship |
| title | The Ansacarbamitocins: Polar Ansamitocin Derivatives |
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