The Burden Borne by Urease

At the active site of urease, urea undergoes nucleophilic attack by water, whereas urea decomposes in solution by elimination of ammonia so that its rate of spontaneous hydrolysis is unknown. Quantum mechanical simulations have been interpreted as indicating that urea hydrolysis is extremely slow, c...

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Veröffentlicht in:	Journal of the American Chemical Society 2005-08, Vol.127 (31), p.10828-10829
Hauptverfasser:	Callahan, Brian P, Yuan, Yang, Wolfenden, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Catalysis Fundamental and applied biological sciences. Psychology Mechanisms. Catalysis. Electron transfer. Models Molecular biophysics Physical chemistry in biology Quantum Theory Urease - antagonists & inhibitors Urease - metabolism
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