Ckap2 regulates aneuploidy, cell cycling, and cell death in a p53-dependent manner

We used DNA microarray screening to identify Ckap2 (cytoskeleton associated protein 2) as a novel p53 target gene in a mouse erythroleukemia cell line. DNA damage induces human and mouse CKAP2 expression in a p53-dependent manner and p53 activates the Ckap2 promoter. Overexpressed Ckap2 colocalizes...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-08, Vol.65 (15), p.6685-6691
Hauptverfasser:	TSUCHIHARA, Katsuya, LAPIN, Valentina, ROTTAPEL, Robert, RICHARDSON, Christopher D, BENCHIMOL, Samuel, TAK WAH MAK, BAKAL, Christopher, OKADA, Hitoshi, BROWN, Lauren, HIROTA-TSUCHIHARA, Masami, ZAUGG, Kathrin, HO, Alexandra, ITIE-YOUTEN, Annick, HARRIS-BRANDTS, Marees
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneuploidy Animals Apoptosis - genetics Biological and medical sciences Cell Cycle - genetics Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Centrosome - physiology Chromosome aberrations Cytoskeletal Proteins - genetics Cytoskeletal Proteins - metabolism Fundamental and applied biological sciences. Psychology HCT116 Cells Humans Leukemia, Erythroblastic, Acute - genetics Leukemia, Erythroblastic, Acute - pathology Medical genetics Medical sciences Mice Microtubules - metabolism Molecular and cellular biology NIH 3T3 Cells Oligonucleotide Array Sequence Analysis Promoter Regions, Genetic Transcriptional Activation Tumor Suppressor Protein p53 - genetics
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