The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women
Summary Objective The objective of this study was to examine whether low levels of oestradiol and testosterone are associated with impaired mobility, low muscle strength and the incidence of falls in a population‐based sample of older men and women. Design Cross‐sectional population‐based study, b...
Gespeichert in:
| Veröffentlicht in: | Clinical endocrinology (Oxford) 2005-08, Vol.63 (2), p.152-160 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 160 |
|---|---|
| container_issue | 2 |
| container_start_page | 152 |
| container_title | Clinical endocrinology (Oxford) |
| container_volume | 63 |
| creator | Schaap, Laura A. Pluijm, Saskia M. F. Smit, Jan H. Van Schoor, Natasja M. Visser, Marjolein Gooren, Louis J. G. Lips, Paul |
| description | Summary
Objective The objective of this study was to examine whether low levels of oestradiol and testosterone are associated with impaired mobility, low muscle strength and the incidence of falls in a population‐based sample of older men and women.
Design Cross‐sectional population‐based study, based on data of the Longitudinal Ageing Study Amsterdam (LASA), including 623 men and 663 women, aged 65–88 years.
Measurements Serum levels of oestradiol, testosterone, albumin and sex hormone‐binding globulin (SHBG) were measured. Physical performance, functional limitations and muscle strength were assessed, and a follow‐up on falls was performed prospectively within 3 years.
Results After adjustment for age, level of education, alcohol use, physical activity, chronic disease and body mass index (BMI), men in the highest quartile of the oestradiol/SHBG ratio had significantly higher physical performance scores than men in the lowest quartile (β = 0·103). Serum levels of total testosterone were positively associated with muscle strength (β = 0·085). Calculated bioavailable testosterone levels were positively associated with physical performance and muscle strength (β = 0·128 and 0·109 respectively). No associations of oestradiol levels with mobility were seen in women. Levels of oestradiol and testosterone were not associated with falls.
Conclusions It can be concluded that low levels of sex hormones were associated with impaired mobility and low muscle strength in men, but not in women. Levels of sex hormones were not associated with the incidence of falls neither in men, nor in women. |
| doi_str_mv | 10.1111/j.1365-2265.2005.02315.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68435761</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>882240951</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5125-a732c02e7ac26412c07bb820709446874f7cf3342bce5950a15211c44bb770a33</originalsourceid><addsrcrecordid>eNqNkUtv1DAUhSMEokPhLyALCVYk-BHbyYJFGXXKoyoSLWJpOZ6bjgcnHuyEmdnw23E6o4JY4Y2P5O8c3euTZYjggqTzZl0QJnhOqeAFxZgXmDLCi92DbHb_8DCbYYZxjoUoT7InMa5xIissH2cnRGCBa1zNsl83K0A6Rm-sHqzvkW9RhB1a-dD5HpCDn-Ai2tphhTbeB9T5xjo77F8j57eoG6NxgOIQoL9NiO6XyPbGLqE3MGW12iW7Tlm3yLslpADo77CtT-pp9igREZ4d79Ps6-L8Zv4-v_x88WF-dpkbTijPtWTUYApSGypKkrRsmopiieuyFJUsW2laxkraGOA1x5pwSogpy6aREmvGTrNXh9xN8D9GiIPqbDTgnO7Bj1GJqmRcCpLAF_-Aaz-GPs2mSF3JqkrBCaoOkAk-xgCt2gTb6bBXBKupILVWUw9q6kFNBam7gtQuWZ8f88emg-Uf47GRBLw8Ajoa7dqg03fGv7haVgxPG709cFvrYP_fA6j5-dWkkj8_-G0cYHfv1-G7EpJJrr5dXajF9adF-fH6i3rHfgM5ybpS</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>198788521</pqid></control><display><type>article</type><title>The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Schaap, Laura A. ; Pluijm, Saskia M. F. ; Smit, Jan H. ; Van Schoor, Natasja M. ; Visser, Marjolein ; Gooren, Louis J. G. ; Lips, Paul</creator><creatorcontrib>Schaap, Laura A. ; Pluijm, Saskia M. F. ; Smit, Jan H. ; Van Schoor, Natasja M. ; Visser, Marjolein ; Gooren, Louis J. G. ; Lips, Paul</creatorcontrib><description>Summary
Objective The objective of this study was to examine whether low levels of oestradiol and testosterone are associated with impaired mobility, low muscle strength and the incidence of falls in a population‐based sample of older men and women.
Design Cross‐sectional population‐based study, based on data of the Longitudinal Ageing Study Amsterdam (LASA), including 623 men and 663 women, aged 65–88 years.
Measurements Serum levels of oestradiol, testosterone, albumin and sex hormone‐binding globulin (SHBG) were measured. Physical performance, functional limitations and muscle strength were assessed, and a follow‐up on falls was performed prospectively within 3 years.
Results After adjustment for age, level of education, alcohol use, physical activity, chronic disease and body mass index (BMI), men in the highest quartile of the oestradiol/SHBG ratio had significantly higher physical performance scores than men in the lowest quartile (β = 0·103). Serum levels of total testosterone were positively associated with muscle strength (β = 0·085). Calculated bioavailable testosterone levels were positively associated with physical performance and muscle strength (β = 0·128 and 0·109 respectively). No associations of oestradiol levels with mobility were seen in women. Levels of oestradiol and testosterone were not associated with falls.
Conclusions It can be concluded that low levels of sex hormones were associated with impaired mobility and low muscle strength in men, but not in women. Levels of sex hormones were not associated with the incidence of falls neither in men, nor in women.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/j.1365-2265.2005.02315.x</identifier><identifier>PMID: 16060908</identifier><identifier>CODEN: CLECAP</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Accidental Falls ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Body Mass Index ; Cross-Sectional Studies ; Disability Evaluation ; Endocrinopathies ; Estradiol - blood ; Exercise Test - methods ; Female ; Fundamental and applied biological sciences. Psychology ; Hand Strength - physiology ; Humans ; Male ; Medical sciences ; Sex Factors ; Sex Hormone-Binding Globulin - analysis ; Testosterone - blood ; Vertebrates: endocrinology</subject><ispartof>Clinical endocrinology (Oxford), 2005-08, Vol.63 (2), p.152-160</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Blackwell Publishing Aug 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5125-a732c02e7ac26412c07bb820709446874f7cf3342bce5950a15211c44bb770a33</citedby><cites>FETCH-LOGICAL-c5125-a732c02e7ac26412c07bb820709446874f7cf3342bce5950a15211c44bb770a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2265.2005.02315.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2265.2005.02315.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16978303$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16060908$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schaap, Laura A.</creatorcontrib><creatorcontrib>Pluijm, Saskia M. F.</creatorcontrib><creatorcontrib>Smit, Jan H.</creatorcontrib><creatorcontrib>Van Schoor, Natasja M.</creatorcontrib><creatorcontrib>Visser, Marjolein</creatorcontrib><creatorcontrib>Gooren, Louis J. G.</creatorcontrib><creatorcontrib>Lips, Paul</creatorcontrib><title>The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol (Oxf)</addtitle><description>Summary
Objective The objective of this study was to examine whether low levels of oestradiol and testosterone are associated with impaired mobility, low muscle strength and the incidence of falls in a population‐based sample of older men and women.
Design Cross‐sectional population‐based study, based on data of the Longitudinal Ageing Study Amsterdam (LASA), including 623 men and 663 women, aged 65–88 years.
Measurements Serum levels of oestradiol, testosterone, albumin and sex hormone‐binding globulin (SHBG) were measured. Physical performance, functional limitations and muscle strength were assessed, and a follow‐up on falls was performed prospectively within 3 years.
Results After adjustment for age, level of education, alcohol use, physical activity, chronic disease and body mass index (BMI), men in the highest quartile of the oestradiol/SHBG ratio had significantly higher physical performance scores than men in the lowest quartile (β = 0·103). Serum levels of total testosterone were positively associated with muscle strength (β = 0·085). Calculated bioavailable testosterone levels were positively associated with physical performance and muscle strength (β = 0·128 and 0·109 respectively). No associations of oestradiol levels with mobility were seen in women. Levels of oestradiol and testosterone were not associated with falls.
Conclusions It can be concluded that low levels of sex hormones were associated with impaired mobility and low muscle strength in men, but not in women. Levels of sex hormones were not associated with the incidence of falls neither in men, nor in women.</description><subject>Accidental Falls</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Cross-Sectional Studies</subject><subject>Disability Evaluation</subject><subject>Endocrinopathies</subject><subject>Estradiol - blood</subject><subject>Exercise Test - methods</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hand Strength - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Sex Factors</subject><subject>Sex Hormone-Binding Globulin - analysis</subject><subject>Testosterone - blood</subject><subject>Vertebrates: endocrinology</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhSMEokPhLyALCVYk-BHbyYJFGXXKoyoSLWJpOZ6bjgcnHuyEmdnw23E6o4JY4Y2P5O8c3euTZYjggqTzZl0QJnhOqeAFxZgXmDLCi92DbHb_8DCbYYZxjoUoT7InMa5xIissH2cnRGCBa1zNsl83K0A6Rm-sHqzvkW9RhB1a-dD5HpCDn-Ai2tphhTbeB9T5xjo77F8j57eoG6NxgOIQoL9NiO6XyPbGLqE3MGW12iW7Tlm3yLslpADo77CtT-pp9igREZ4d79Ps6-L8Zv4-v_x88WF-dpkbTijPtWTUYApSGypKkrRsmopiieuyFJUsW2laxkraGOA1x5pwSogpy6aREmvGTrNXh9xN8D9GiIPqbDTgnO7Bj1GJqmRcCpLAF_-Aaz-GPs2mSF3JqkrBCaoOkAk-xgCt2gTb6bBXBKupILVWUw9q6kFNBam7gtQuWZ8f88emg-Uf47GRBLw8Ajoa7dqg03fGv7haVgxPG709cFvrYP_fA6j5-dWkkj8_-G0cYHfv1-G7EpJJrr5dXajF9adF-fH6i3rHfgM5ybpS</recordid><startdate>200508</startdate><enddate>200508</enddate><creator>Schaap, Laura A.</creator><creator>Pluijm, Saskia M. F.</creator><creator>Smit, Jan H.</creator><creator>Van Schoor, Natasja M.</creator><creator>Visser, Marjolein</creator><creator>Gooren, Louis J. G.</creator><creator>Lips, Paul</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>200508</creationdate><title>The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women</title><author>Schaap, Laura A. ; Pluijm, Saskia M. F. ; Smit, Jan H. ; Van Schoor, Natasja M. ; Visser, Marjolein ; Gooren, Louis J. G. ; Lips, Paul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5125-a732c02e7ac26412c07bb820709446874f7cf3342bce5950a15211c44bb770a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Accidental Falls</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Cross-Sectional Studies</topic><topic>Disability Evaluation</topic><topic>Endocrinopathies</topic><topic>Estradiol - blood</topic><topic>Exercise Test - methods</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hand Strength - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Sex Factors</topic><topic>Sex Hormone-Binding Globulin - analysis</topic><topic>Testosterone - blood</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schaap, Laura A.</creatorcontrib><creatorcontrib>Pluijm, Saskia M. F.</creatorcontrib><creatorcontrib>Smit, Jan H.</creatorcontrib><creatorcontrib>Van Schoor, Natasja M.</creatorcontrib><creatorcontrib>Visser, Marjolein</creatorcontrib><creatorcontrib>Gooren, Louis J. G.</creatorcontrib><creatorcontrib>Lips, Paul</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schaap, Laura A.</au><au>Pluijm, Saskia M. F.</au><au>Smit, Jan H.</au><au>Van Schoor, Natasja M.</au><au>Visser, Marjolein</au><au>Gooren, Louis J. G.</au><au>Lips, Paul</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol (Oxf)</addtitle><date>2005-08</date><risdate>2005</risdate><volume>63</volume><issue>2</issue><spage>152</spage><epage>160</epage><pages>152-160</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><coden>CLECAP</coden><abstract>Summary
Objective The objective of this study was to examine whether low levels of oestradiol and testosterone are associated with impaired mobility, low muscle strength and the incidence of falls in a population‐based sample of older men and women.
Design Cross‐sectional population‐based study, based on data of the Longitudinal Ageing Study Amsterdam (LASA), including 623 men and 663 women, aged 65–88 years.
Measurements Serum levels of oestradiol, testosterone, albumin and sex hormone‐binding globulin (SHBG) were measured. Physical performance, functional limitations and muscle strength were assessed, and a follow‐up on falls was performed prospectively within 3 years.
Results After adjustment for age, level of education, alcohol use, physical activity, chronic disease and body mass index (BMI), men in the highest quartile of the oestradiol/SHBG ratio had significantly higher physical performance scores than men in the lowest quartile (β = 0·103). Serum levels of total testosterone were positively associated with muscle strength (β = 0·085). Calculated bioavailable testosterone levels were positively associated with physical performance and muscle strength (β = 0·128 and 0·109 respectively). No associations of oestradiol levels with mobility were seen in women. Levels of oestradiol and testosterone were not associated with falls.
Conclusions It can be concluded that low levels of sex hormones were associated with impaired mobility and low muscle strength in men, but not in women. Levels of sex hormones were not associated with the incidence of falls neither in men, nor in women.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>16060908</pmid><doi>10.1111/j.1365-2265.2005.02315.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-0664 |
| ispartof | Clinical endocrinology (Oxford), 2005-08, Vol.63 (2), p.152-160 |
| issn | 0300-0664 1365-2265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68435761 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Accidental Falls Aged Aged, 80 and over Biological and medical sciences Body Mass Index Cross-Sectional Studies Disability Evaluation Endocrinopathies Estradiol - blood Exercise Test - methods Female Fundamental and applied biological sciences. Psychology Hand Strength - physiology Humans Male Medical sciences Sex Factors Sex Hormone-Binding Globulin - analysis Testosterone - blood Vertebrates: endocrinology |
| title | The association of sex hormone levels with poor mobility, low muscle strength and incidence of falls among older men and women |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T19%3A32%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20association%20of%20sex%20hormone%20levels%20with%20poor%20mobility,%20low%20muscle%20strength%20and%20incidence%20of%20falls%20among%20older%20men%20and%20women&rft.jtitle=Clinical%20endocrinology%20(Oxford)&rft.au=Schaap,%20Laura%20A.&rft.date=2005-08&rft.volume=63&rft.issue=2&rft.spage=152&rft.epage=160&rft.pages=152-160&rft.issn=0300-0664&rft.eissn=1365-2265&rft.coden=CLECAP&rft_id=info:doi/10.1111/j.1365-2265.2005.02315.x&rft_dat=%3Cproquest_cross%3E882240951%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=198788521&rft_id=info:pmid/16060908&rfr_iscdi=true |