Angiogenesis in the Bone Marrow of Patients with Breast Cancer
Purpose: Pathologic angiogenesis has been correlated with tumor growth, dissemination, metastasis, and prognosis in solid tumors including breast cancer. Angiogenesis has also been implicated in the pathophysiology of, and shown to be a therapeutic target in tumors arising in the bone marrow. The st...
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| Veröffentlicht in: | Clinical cancer research 2005-08, Vol.11 (15), p.5396-5400 |
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| creator | Chavez-Macgregor, Mariana Aviles-Salas, Alejandro Green, Dan Fuentes-Alburo, Adolfo Gómez-Ruiz, Celedonio Aguayo, Alvaro |
| description | Purpose: Pathologic angiogenesis has been correlated with tumor growth, dissemination, metastasis, and prognosis in solid tumors including
breast cancer. Angiogenesis has also been implicated in the pathophysiology of, and shown to be a therapeutic target in tumors
arising in the bone marrow. The status of angiogenesis in the bone marrow of breast cancer patients is unknown. The aim of
this study was to estimate the extent of bone marrow angiogenesis in this subset of patients.
Experimental Design: We studied 42 women with breast cancer in whom a bone marrow biopsy was done. Bone marrow samples were sorted according to
their infiltration status by breast cancer cells. In all bone marrow sections, blood vessels were highlighted by staining
endothelial cells with an antibody directed against the CD34-related antigen. A hematopathologist blind to the status of infiltration
of breast cancer did the bone marrow vessel count.
Results: Nineteen patients (45%) had bone marrow metastasis. The bone marrow microvessel density was significantly higher in patients
with bone marrow metastases compared with patients without bone marrow metastases ( P < 0.0005). Median bone marrow microvessel density was 2 for the negative bone marrow group, and 15 for the positive bone
marrow group. An increased microvessel density was correlated with presence of disease at last follow-up.
Conclusions: This is the first study showing that bone marrow microvessel density is significantly higher in breast cancer patients with
bone marrow metastases, when compared with breast cancer patients without evidence of bone marrow metastatic disease. Further
research is needed to shed light into the prognostic and therapeutic relevance of this finding. |
| doi_str_mv | 10.1158/1078-0432.CCR-04-2420 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68435634</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>68435634</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-d5b439588827d311308280edead5827e69f0c7082da843ba12ac3de042dbabfb3</originalsourceid><addsrcrecordid>eNpNkF1LwzAUhoMobk5_gpIbBS-qSZO06Y2wFb9goohehzQ9XSNbO5OO4b83dRW9ysvheZOTB6FTSq4oFfKaklRGhLP4Ks9fQ4hiHpM9NKZCpBGLE7Ef8i8zQkfefxBCOSX8EI1oQhIqBRujm2mzsO0CGvDWY9vgrgY8axvAT9q5dovbCr_ozkLTeby1XY1nDrTvcK4bA-4YHVR66eFkOCfo_e72LX-I5s_3j_l0Hhmeki4qRcFZJqSUcVoyShmRsSRQgi5FGEGSVcSkYVhqyVmhaawNK4HwuCx0URVsgi52965d-7kB36mV9QaWS91Au_EqCTWRMB5AsQONa713UKm1syvtvhQlqheneimql6KCuBBULy70zoYHNsUKyr_WYCoA5wOgvdHLyoX_W_-Py6RMWRa4yx1X20W9tQ6U-THlwIN2pg5LKCqUYFnCvgH3-YMU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68435634</pqid></control><display><type>article</type><title>Angiogenesis in the Bone Marrow of Patients with Breast Cancer</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Chavez-Macgregor, Mariana ; Aviles-Salas, Alejandro ; Green, Dan ; Fuentes-Alburo, Adolfo ; Gómez-Ruiz, Celedonio ; Aguayo, Alvaro</creator><creatorcontrib>Chavez-Macgregor, Mariana ; Aviles-Salas, Alejandro ; Green, Dan ; Fuentes-Alburo, Adolfo ; Gómez-Ruiz, Celedonio ; Aguayo, Alvaro</creatorcontrib><description>Purpose: Pathologic angiogenesis has been correlated with tumor growth, dissemination, metastasis, and prognosis in solid tumors including
breast cancer. Angiogenesis has also been implicated in the pathophysiology of, and shown to be a therapeutic target in tumors
arising in the bone marrow. The status of angiogenesis in the bone marrow of breast cancer patients is unknown. The aim of
this study was to estimate the extent of bone marrow angiogenesis in this subset of patients.
Experimental Design: We studied 42 women with breast cancer in whom a bone marrow biopsy was done. Bone marrow samples were sorted according to
their infiltration status by breast cancer cells. In all bone marrow sections, blood vessels were highlighted by staining
endothelial cells with an antibody directed against the CD34-related antigen. A hematopathologist blind to the status of infiltration
of breast cancer did the bone marrow vessel count.
Results: Nineteen patients (45%) had bone marrow metastasis. The bone marrow microvessel density was significantly higher in patients
with bone marrow metastases compared with patients without bone marrow metastases ( P < 0.0005). Median bone marrow microvessel density was 2 for the negative bone marrow group, and 15 for the positive bone
marrow group. An increased microvessel density was correlated with presence of disease at last follow-up.
Conclusions: This is the first study showing that bone marrow microvessel density is significantly higher in breast cancer patients with
bone marrow metastases, when compared with breast cancer patients without evidence of bone marrow metastatic disease. Further
research is needed to shed light into the prognostic and therapeutic relevance of this finding.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-04-2420</identifier><identifier>PMID: 16061853</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Antigens, CD34 - biosynthesis ; Antineoplastic agents ; Biological and medical sciences ; Bone Marrow - pathology ; Bone Marrow Cells - cytology ; Bone Marrow Cells - metabolism ; Bone Marrow Cells - pathology ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; CD34 ; Cell Differentiation ; Cell Proliferation ; Female ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Medical sciences ; Microcirculation ; micrometastases ; microvessel density ; Middle Aged ; Neoplasm Metastasis ; Neovascularization, Pathologic ; Odds Ratio ; Pharmacology. Drug treatments ; Prognosis</subject><ispartof>Clinical cancer research, 2005-08, Vol.11 (15), p.5396-5400</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-d5b439588827d311308280edead5827e69f0c7082da843ba12ac3de042dbabfb3</citedby><cites>FETCH-LOGICAL-c470t-d5b439588827d311308280edead5827e69f0c7082da843ba12ac3de042dbabfb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3343,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16988739$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16061853$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chavez-Macgregor, Mariana</creatorcontrib><creatorcontrib>Aviles-Salas, Alejandro</creatorcontrib><creatorcontrib>Green, Dan</creatorcontrib><creatorcontrib>Fuentes-Alburo, Adolfo</creatorcontrib><creatorcontrib>Gómez-Ruiz, Celedonio</creatorcontrib><creatorcontrib>Aguayo, Alvaro</creatorcontrib><title>Angiogenesis in the Bone Marrow of Patients with Breast Cancer</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Purpose: Pathologic angiogenesis has been correlated with tumor growth, dissemination, metastasis, and prognosis in solid tumors including
breast cancer. Angiogenesis has also been implicated in the pathophysiology of, and shown to be a therapeutic target in tumors
arising in the bone marrow. The status of angiogenesis in the bone marrow of breast cancer patients is unknown. The aim of
this study was to estimate the extent of bone marrow angiogenesis in this subset of patients.
Experimental Design: We studied 42 women with breast cancer in whom a bone marrow biopsy was done. Bone marrow samples were sorted according to
their infiltration status by breast cancer cells. In all bone marrow sections, blood vessels were highlighted by staining
endothelial cells with an antibody directed against the CD34-related antigen. A hematopathologist blind to the status of infiltration
of breast cancer did the bone marrow vessel count.
Results: Nineteen patients (45%) had bone marrow metastasis. The bone marrow microvessel density was significantly higher in patients
with bone marrow metastases compared with patients without bone marrow metastases ( P < 0.0005). Median bone marrow microvessel density was 2 for the negative bone marrow group, and 15 for the positive bone
marrow group. An increased microvessel density was correlated with presence of disease at last follow-up.
Conclusions: This is the first study showing that bone marrow microvessel density is significantly higher in breast cancer patients with
bone marrow metastases, when compared with breast cancer patients without evidence of bone marrow metastatic disease. Further
research is needed to shed light into the prognostic and therapeutic relevance of this finding.</description><subject>Adult</subject><subject>Antigens, CD34 - biosynthesis</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow - pathology</subject><subject>Bone Marrow Cells - cytology</subject><subject>Bone Marrow Cells - metabolism</subject><subject>Bone Marrow Cells - pathology</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>CD34</subject><subject>Cell Differentiation</subject><subject>Cell Proliferation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphatic Metastasis</subject><subject>Medical sciences</subject><subject>Microcirculation</subject><subject>micrometastases</subject><subject>microvessel density</subject><subject>Middle Aged</subject><subject>Neoplasm Metastasis</subject><subject>Neovascularization, Pathologic</subject><subject>Odds Ratio</subject><subject>Pharmacology. Drug treatments</subject><subject>Prognosis</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkF1LwzAUhoMobk5_gpIbBS-qSZO06Y2wFb9goohehzQ9XSNbO5OO4b83dRW9ysvheZOTB6FTSq4oFfKaklRGhLP4Ks9fQ4hiHpM9NKZCpBGLE7Ef8i8zQkfefxBCOSX8EI1oQhIqBRujm2mzsO0CGvDWY9vgrgY8axvAT9q5dovbCr_ozkLTeby1XY1nDrTvcK4bA-4YHVR66eFkOCfo_e72LX-I5s_3j_l0Hhmeki4qRcFZJqSUcVoyShmRsSRQgi5FGEGSVcSkYVhqyVmhaawNK4HwuCx0URVsgi52965d-7kB36mV9QaWS91Au_EqCTWRMB5AsQONa713UKm1syvtvhQlqheneimql6KCuBBULy70zoYHNsUKyr_WYCoA5wOgvdHLyoX_W_-Py6RMWRa4yx1X20W9tQ6U-THlwIN2pg5LKCqUYFnCvgH3-YMU</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Chavez-Macgregor, Mariana</creator><creator>Aviles-Salas, Alejandro</creator><creator>Green, Dan</creator><creator>Fuentes-Alburo, Adolfo</creator><creator>Gómez-Ruiz, Celedonio</creator><creator>Aguayo, Alvaro</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Angiogenesis in the Bone Marrow of Patients with Breast Cancer</title><author>Chavez-Macgregor, Mariana ; Aviles-Salas, Alejandro ; Green, Dan ; Fuentes-Alburo, Adolfo ; Gómez-Ruiz, Celedonio ; Aguayo, Alvaro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-d5b439588827d311308280edead5827e69f0c7082da843ba12ac3de042dbabfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Antigens, CD34 - biosynthesis</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow - pathology</topic><topic>Bone Marrow Cells - cytology</topic><topic>Bone Marrow Cells - metabolism</topic><topic>Bone Marrow Cells - pathology</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>CD34</topic><topic>Cell Differentiation</topic><topic>Cell Proliferation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic Metastasis</topic><topic>Medical sciences</topic><topic>Microcirculation</topic><topic>micrometastases</topic><topic>microvessel density</topic><topic>Middle Aged</topic><topic>Neoplasm Metastasis</topic><topic>Neovascularization, Pathologic</topic><topic>Odds Ratio</topic><topic>Pharmacology. Drug treatments</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chavez-Macgregor, Mariana</creatorcontrib><creatorcontrib>Aviles-Salas, Alejandro</creatorcontrib><creatorcontrib>Green, Dan</creatorcontrib><creatorcontrib>Fuentes-Alburo, Adolfo</creatorcontrib><creatorcontrib>Gómez-Ruiz, Celedonio</creatorcontrib><creatorcontrib>Aguayo, Alvaro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chavez-Macgregor, Mariana</au><au>Aviles-Salas, Alejandro</au><au>Green, Dan</au><au>Fuentes-Alburo, Adolfo</au><au>Gómez-Ruiz, Celedonio</au><au>Aguayo, Alvaro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Angiogenesis in the Bone Marrow of Patients with Breast Cancer</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>11</volume><issue>15</issue><spage>5396</spage><epage>5400</epage><pages>5396-5400</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Purpose: Pathologic angiogenesis has been correlated with tumor growth, dissemination, metastasis, and prognosis in solid tumors including
breast cancer. Angiogenesis has also been implicated in the pathophysiology of, and shown to be a therapeutic target in tumors
arising in the bone marrow. The status of angiogenesis in the bone marrow of breast cancer patients is unknown. The aim of
this study was to estimate the extent of bone marrow angiogenesis in this subset of patients.
Experimental Design: We studied 42 women with breast cancer in whom a bone marrow biopsy was done. Bone marrow samples were sorted according to
their infiltration status by breast cancer cells. In all bone marrow sections, blood vessels were highlighted by staining
endothelial cells with an antibody directed against the CD34-related antigen. A hematopathologist blind to the status of infiltration
of breast cancer did the bone marrow vessel count.
Results: Nineteen patients (45%) had bone marrow metastasis. The bone marrow microvessel density was significantly higher in patients
with bone marrow metastases compared with patients without bone marrow metastases ( P < 0.0005). Median bone marrow microvessel density was 2 for the negative bone marrow group, and 15 for the positive bone
marrow group. An increased microvessel density was correlated with presence of disease at last follow-up.
Conclusions: This is the first study showing that bone marrow microvessel density is significantly higher in breast cancer patients with
bone marrow metastases, when compared with breast cancer patients without evidence of bone marrow metastatic disease. Further
research is needed to shed light into the prognostic and therapeutic relevance of this finding.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>16061853</pmid><doi>10.1158/1078-0432.CCR-04-2420</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Adult Antigens, CD34 - biosynthesis Antineoplastic agents Biological and medical sciences Bone Marrow - pathology Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Bone Marrow Cells - pathology Breast Neoplasms - metabolism Breast Neoplasms - pathology CD34 Cell Differentiation Cell Proliferation Female Follow-Up Studies Humans Immunohistochemistry Lymphatic Metastasis Medical sciences Microcirculation micrometastases microvessel density Middle Aged Neoplasm Metastasis Neovascularization, Pathologic Odds Ratio Pharmacology. Drug treatments Prognosis |
| title | Angiogenesis in the Bone Marrow of Patients with Breast Cancer |
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