DISC1 and neurocognitive function in schizophrenia
We recently reported an association between DISC1 and schizophrenia, schizoaffective disorder, and bipolar disorder. Convergent evidence suggests that DISC1 has a direct effect on central nervous system functioning. However, there is a paucity of data investigating the effects of DISC1 on neurocogni...
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| Veröffentlicht in: | Neuroreport 2005-08, Vol.16 (12), p.1399-1402 |
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| creator | Burdick, Katherine E Hodgkinson, Colin A Szeszko, Philip R Lencz, Todd Ekholm, Jenny M Kane, John M Goldman, David Malhotra, Anil K |
| description | We recently reported an association between DISC1 and schizophrenia, schizoaffective disorder, and bipolar disorder. Convergent evidence suggests that DISC1 has a direct effect on central nervous system functioning. However, there is a paucity of data investigating the effects of DISC1 on neurocognition. Thus, we analyzed the relationship between five single-nucleotide polymorphisms that influenced risk for schizophrenia in our previous study and neurocognition in 250 patients with schizophrenia. DISC1 genotype was related to neurocognitive performance on measures of rapid visual search and verbal working memory, when controlling for age and premorbid intellectual capacity, and explained 3%–4% of the variance. These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia. |
| doi_str_mv | 10.1097/01.wnr.0000175248.25535.f6 |
| format | Article |
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Convergent evidence suggests that DISC1 has a direct effect on central nervous system functioning. However, there is a paucity of data investigating the effects of DISC1 on neurocognition. Thus, we analyzed the relationship between five single-nucleotide polymorphisms that influenced risk for schizophrenia in our previous study and neurocognition in 250 patients with schizophrenia. DISC1 genotype was related to neurocognitive performance on measures of rapid visual search and verbal working memory, when controlling for age and premorbid intellectual capacity, and explained 3%–4% of the variance. These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/01.wnr.0000175248.25535.f6</identifier><identifier>PMID: 16056147</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; Adult and adolescent clinical studies ; Analysis of Variance ; Biological and medical sciences ; Cognition - physiology ; Female ; Gene Frequency ; Genotype ; Humans ; Linkage Disequilibrium ; Male ; Medical sciences ; Memory, Short-Term - physiology ; Middle Aged ; Nerve Tissue Proteins - genetics ; Neuropsychological Tests - statistics & numerical data ; Polymorphism, Single Nucleotide - genetics ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. 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Convergent evidence suggests that DISC1 has a direct effect on central nervous system functioning. However, there is a paucity of data investigating the effects of DISC1 on neurocognition. Thus, we analyzed the relationship between five single-nucleotide polymorphisms that influenced risk for schizophrenia in our previous study and neurocognition in 250 patients with schizophrenia. DISC1 genotype was related to neurocognitive performance on measures of rapid visual search and verbal working memory, when controlling for age and premorbid intellectual capacity, and explained 3%–4% of the variance. These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Cognition - physiology</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genotype</subject><subject>Humans</subject><subject>Linkage Disequilibrium</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory, Short-Term - physiology</subject><subject>Middle Aged</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Neuropsychological Tests - statistics & numerical data</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Risk</subject><subject>Schizophrenia</subject><subject>Schizophrenia - genetics</subject><subject>Schizophrenia - physiopathology</subject><subject>Verbal Learning - physiology</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0E9rFDEYBvAgFrutfgUZBL3N9M3_xJtstRYKHlTwFjKZxI3OZtZkxqV-elN3ZY_NJSH83veBB6FXGDoMWl4B7vYpd1APlpww1RHOKe-CeIJWmEnacq6-PUUr0Fy3TAt-ji5K-VG9BqyeoXMsgIsqV4hc335e48amoUl-yZObvqc4x9--CUtyc5xSE1NT3Cb-mXab7FO0z9FZsGPxL473Jfr64f2X9cf27tPN7frdXesYJ6r1vA9WDsoPGLzWlvp-0L0Og5PBg9IMesmU1Uw6FwZmBRWDHfr6sJYGLeglenPYu8vTr8WX2WxjcX4cbfLTUoxQjHLKHocEOCZU0QrfHqDLUynZB7PLcWvzvcFgHqo1gE2t1pyqNf-qNeEh5eUxZem3fjiNHrus4PUR2OLsGLJNLpaTk0A1law6dnD7aZx9Lj_HZe-z2Xg7zpv_0aIlABwUIdDWH6LoXzXYkwg</recordid><startdate>20050822</startdate><enddate>20050822</enddate><creator>Burdick, Katherine E</creator><creator>Hodgkinson, Colin A</creator><creator>Szeszko, Philip R</creator><creator>Lencz, Todd</creator><creator>Ekholm, Jenny M</creator><creator>Kane, John M</creator><creator>Goldman, David</creator><creator>Malhotra, Anil K</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20050822</creationdate><title>DISC1 and neurocognitive function in schizophrenia</title><author>Burdick, Katherine E ; Hodgkinson, Colin A ; Szeszko, Philip R ; Lencz, Todd ; Ekholm, Jenny M ; Kane, John M ; Goldman, David ; Malhotra, Anil K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4528-e5bfa7d8ed10e99a3ebd9b9fdc7fe08940b748a947ccfd4a636dadb4a6aa3f963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Cognition - physiology</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genotype</topic><topic>Humans</topic><topic>Linkage Disequilibrium</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory, Short-Term - physiology</topic><topic>Middle Aged</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Neuropsychological Tests - statistics & numerical data</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Risk</topic><topic>Schizophrenia</topic><topic>Schizophrenia - genetics</topic><topic>Schizophrenia - physiopathology</topic><topic>Verbal Learning - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burdick, Katherine E</creatorcontrib><creatorcontrib>Hodgkinson, Colin A</creatorcontrib><creatorcontrib>Szeszko, Philip R</creatorcontrib><creatorcontrib>Lencz, Todd</creatorcontrib><creatorcontrib>Ekholm, Jenny M</creatorcontrib><creatorcontrib>Kane, John M</creatorcontrib><creatorcontrib>Goldman, David</creatorcontrib><creatorcontrib>Malhotra, Anil K</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroreport</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burdick, Katherine E</au><au>Hodgkinson, Colin A</au><au>Szeszko, Philip R</au><au>Lencz, Todd</au><au>Ekholm, Jenny M</au><au>Kane, John M</au><au>Goldman, David</au><au>Malhotra, Anil K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DISC1 and neurocognitive function in schizophrenia</atitle><jtitle>Neuroreport</jtitle><addtitle>Neuroreport</addtitle><date>2005-08-22</date><risdate>2005</risdate><volume>16</volume><issue>12</issue><spage>1399</spage><epage>1402</epage><pages>1399-1402</pages><issn>0959-4965</issn><eissn>1473-558X</eissn><abstract>We recently reported an association between DISC1 and schizophrenia, schizoaffective disorder, and bipolar disorder. Convergent evidence suggests that DISC1 has a direct effect on central nervous system functioning. However, there is a paucity of data investigating the effects of DISC1 on neurocognition. Thus, we analyzed the relationship between five single-nucleotide polymorphisms that influenced risk for schizophrenia in our previous study and neurocognition in 250 patients with schizophrenia. DISC1 genotype was related to neurocognitive performance on measures of rapid visual search and verbal working memory, when controlling for age and premorbid intellectual capacity, and explained 3%–4% of the variance. These data suggest that DISC1 is associated with neurocognitive functioning in schizophrenia.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>16056147</pmid><doi>10.1097/01.wnr.0000175248.25535.f6</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Analysis of Variance Biological and medical sciences Cognition - physiology Female Gene Frequency Genotype Humans Linkage Disequilibrium Male Medical sciences Memory, Short-Term - physiology Middle Aged Nerve Tissue Proteins - genetics Neuropsychological Tests - statistics & numerical data Polymorphism, Single Nucleotide - genetics Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Risk Schizophrenia Schizophrenia - genetics Schizophrenia - physiopathology Verbal Learning - physiology |
| title | DISC1 and neurocognitive function in schizophrenia |
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