Long-term survival of bone marrow-derived retinal nerve cells in the retina
Recently, we have demonstrated that bone marrow stem cells can differentiate into retinal nerve cells. In the present study, we show a new and efficient strategy for transplanting bone marrow stem cells into the retina. When bone marrow stem cells were injected into the vitreous cavity of untreated...
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| Veröffentlicht in: | Neuroreport 2005-08, Vol.16 (12), p.1255-1259 |
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| creator | Minamino, Keizo Adachi, Yasushi Yamada, Haruhiko Higuchi, Akiko Suzuki, Yasuhiro Iwasaki, Masayoshi Nakano, Keiji Koike, Yasushi Mukaide, Hiromi Kiriyama, Naoko Shigematsu, Akio Matsumura, Miyo Ikehara, Susumu |
| description | Recently, we have demonstrated that bone marrow stem cells can differentiate into retinal nerve cells. In the present study, we show a new and efficient strategy for transplanting bone marrow stem cells into the retina. When bone marrow stem cells were injected into the vitreous cavity of untreated eyes, only very few cells were found in the retina 2 weeks after injection. In contrast, when laser photocoagulation was performed just before the injection of bone marrow stem cells, a large number of the injected cells survived 2 weeks after injection and the cells expressed neural cell-specific or retinal nerve cell-specific antigens. Moreover, we still detected bone marrow stem cell-derived retinal nerve cells in the retina 1 year after injection in the retina. |
| doi_str_mv | 10.1097/01.wnr.0000176517.96475.18 |
| format | Article |
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In the present study, we show a new and efficient strategy for transplanting bone marrow stem cells into the retina. When bone marrow stem cells were injected into the vitreous cavity of untreated eyes, only very few cells were found in the retina 2 weeks after injection. In contrast, when laser photocoagulation was performed just before the injection of bone marrow stem cells, a large number of the injected cells survived 2 weeks after injection and the cells expressed neural cell-specific or retinal nerve cell-specific antigens. Moreover, we still detected bone marrow stem cell-derived retinal nerve cells in the retina 1 year after injection in the retina.</description><identifier>ISSN: 0959-4965</identifier><identifier>EISSN: 1473-558X</identifier><identifier>DOI: 10.1097/01.wnr.0000176517.96475.18</identifier><identifier>PMID: 16056120</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Analysis of Variance ; Animals ; Biological and medical sciences ; Bone Marrow Transplantation - methods ; Cell Count - methods ; Development. Senescence. Regeneration. Transplantation ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Graft Survival - physiology ; Green Fluorescent Proteins - biosynthesis ; Immunohistochemistry - methods ; Intermediate Filament Proteins - metabolism ; Light Coagulation - methods ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microscopy, Confocal - methods ; Microtubule-Associated Proteins - metabolism ; Nerve Tissue Proteins - metabolism ; Nestin ; Neurons - physiology ; Retina - cytology ; Rhodopsin - metabolism ; Stem Cells - physiology ; Time Factors ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroreport, 2005-08, Vol.16 (12), p.1255-1259</ispartof><rights>2005 Lippincott Williams & Wilkins, Inc.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4231-501301bb7a1f2f7cc6dc4c74a29109f73facc9a19956fda9d4b20d88e590d4bb3</citedby><cites>FETCH-LOGICAL-c4231-501301bb7a1f2f7cc6dc4c74a29109f73facc9a19956fda9d4b20d88e590d4bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17039347$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16056120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Minamino, Keizo</creatorcontrib><creatorcontrib>Adachi, Yasushi</creatorcontrib><creatorcontrib>Yamada, Haruhiko</creatorcontrib><creatorcontrib>Higuchi, Akiko</creatorcontrib><creatorcontrib>Suzuki, Yasuhiro</creatorcontrib><creatorcontrib>Iwasaki, Masayoshi</creatorcontrib><creatorcontrib>Nakano, Keiji</creatorcontrib><creatorcontrib>Koike, Yasushi</creatorcontrib><creatorcontrib>Mukaide, Hiromi</creatorcontrib><creatorcontrib>Kiriyama, Naoko</creatorcontrib><creatorcontrib>Shigematsu, Akio</creatorcontrib><creatorcontrib>Matsumura, Miyo</creatorcontrib><creatorcontrib>Ikehara, Susumu</creatorcontrib><title>Long-term survival of bone marrow-derived retinal nerve cells in the retina</title><title>Neuroreport</title><addtitle>Neuroreport</addtitle><description>Recently, we have demonstrated that bone marrow stem cells can differentiate into retinal nerve cells. In the present study, we show a new and efficient strategy for transplanting bone marrow stem cells into the retina. When bone marrow stem cells were injected into the vitreous cavity of untreated eyes, only very few cells were found in the retina 2 weeks after injection. In contrast, when laser photocoagulation was performed just before the injection of bone marrow stem cells, a large number of the injected cells survived 2 weeks after injection and the cells expressed neural cell-specific or retinal nerve cell-specific antigens. Moreover, we still detected bone marrow stem cell-derived retinal nerve cells in the retina 1 year after injection in the retina.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation - methods</subject><subject>Cell Count - methods</subject><subject>Development. Senescence. Regeneration. Transplantation</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Graft Survival - physiology</subject><subject>Green Fluorescent Proteins - biosynthesis</subject><subject>Immunohistochemistry - methods</subject><subject>Intermediate Filament Proteins - metabolism</subject><subject>Light Coagulation - methods</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Microscopy, Confocal - methods</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Nestin</subject><subject>Neurons - physiology</subject><subject>Retina - cytology</subject><subject>Rhodopsin - metabolism</subject><subject>Stem Cells - physiology</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0959-4965</issn><issn>1473-558X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuP0zAQgC0EYkvhL6AICW4OM36bG1otD1GJC0jcLMdxaCBNFjtpxb_H3UbqEV9seb7xeL4h5BVCjWD1W8D6NKYaykKtJOraKqFljeYR2aDQnEppfjwmG7DSUmGVvCHPcv5VeAtonpIbVCAVMtiQL7tp_EnnmA5VXtKxP_qhmrqqmcZYHXxK04m2MfXH2FYpzv1YwmNMx1iFOAy56sdq3sc19Jw86fyQ44t135LvH-6-3X6iu68fP9--39EgGEcqATlg02iPHet0CKoNImjhmS3tdZp3PgTr0VqputbbVjQMWmOitFDODd-SN5d379P0Z4l5doc-n__jxzgt2SkjuLAG_gsykGg1mAK-u4AhTTmn2Ln71Jf2_zoEd3buAF1x7q7O3YNzh-fkl2uVpTnE9pq6Si7A6xXwOfihS34Mfb5yGrjlZWxbIi7caRrKRPLvYTnF5PbRD_N-LS0VZQASDGNAH674P-wGmr4</recordid><startdate>20050822</startdate><enddate>20050822</enddate><creator>Minamino, Keizo</creator><creator>Adachi, Yasushi</creator><creator>Yamada, Haruhiko</creator><creator>Higuchi, Akiko</creator><creator>Suzuki, Yasuhiro</creator><creator>Iwasaki, Masayoshi</creator><creator>Nakano, Keiji</creator><creator>Koike, Yasushi</creator><creator>Mukaide, Hiromi</creator><creator>Kiriyama, Naoko</creator><creator>Shigematsu, Akio</creator><creator>Matsumura, Miyo</creator><creator>Ikehara, Susumu</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams and Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20050822</creationdate><title>Long-term survival of bone marrow-derived retinal nerve cells in the retina</title><author>Minamino, Keizo ; Adachi, Yasushi ; Yamada, Haruhiko ; Higuchi, Akiko ; Suzuki, Yasuhiro ; Iwasaki, Masayoshi ; Nakano, Keiji ; Koike, Yasushi ; Mukaide, Hiromi ; Kiriyama, Naoko ; Shigematsu, Akio ; Matsumura, Miyo ; Ikehara, Susumu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4231-501301bb7a1f2f7cc6dc4c74a29109f73facc9a19956fda9d4b20d88e590d4bb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Transplantation - methods</topic><topic>Cell Count - methods</topic><topic>Development. Senescence. Regeneration. Transplantation</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. 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In the present study, we show a new and efficient strategy for transplanting bone marrow stem cells into the retina. When bone marrow stem cells were injected into the vitreous cavity of untreated eyes, only very few cells were found in the retina 2 weeks after injection. In contrast, when laser photocoagulation was performed just before the injection of bone marrow stem cells, a large number of the injected cells survived 2 weeks after injection and the cells expressed neural cell-specific or retinal nerve cell-specific antigens. Moreover, we still detected bone marrow stem cell-derived retinal nerve cells in the retina 1 year after injection in the retina.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>16056120</pmid><doi>10.1097/01.wnr.0000176517.96475.18</doi><tpages>5</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Biological and medical sciences Bone Marrow Transplantation - methods Cell Count - methods Development. Senescence. Regeneration. Transplantation Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Graft Survival - physiology Green Fluorescent Proteins - biosynthesis Immunohistochemistry - methods Intermediate Filament Proteins - metabolism Light Coagulation - methods Mice Mice, Inbred C57BL Mice, Transgenic Microscopy, Confocal - methods Microtubule-Associated Proteins - metabolism Nerve Tissue Proteins - metabolism Nestin Neurons - physiology Retina - cytology Rhodopsin - metabolism Stem Cells - physiology Time Factors Vertebrates: nervous system and sense organs |
| title | Long-term survival of bone marrow-derived retinal nerve cells in the retina |
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