RutR is the uracil/thymine-sensing master regulator of a set of genes for synthesis and degradation of pyrimidines

Using the genomic SELEX, a total of six Escherichia coli DNA fragments have been identified, which formed complexes with transcription factor RutR. The RutR regulon was found to include a large number of genes encoding components for not only degradation of pyrimidines but also transport of glutamat...

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Veröffentlicht in:	Molecular microbiology 2007-11, Vol.66 (3), p.744-757
Hauptverfasser:	Shimada, Tomohiro, Hirao, Kiyo, Kori, Ayako, Yamamoto, Kaneyoshi, Ishihama, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Allantoin - metabolism Aptamers, Nucleotide - genetics Aptamers, Nucleotide - metabolism Bacteriology Base Sequence Binding sites Binding Sites - genetics Biological and medical sciences Blotting, Northern Deoxyribonuclease I - metabolism DNA fingerprints DNA Footprinting - methods E coli Electrophoretic Mobility Shift Assay Enzymes Escherichia coli Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Bacterial Genes Genetics Glutamic Acid - metabolism Microbiology Models, Biological Mutation Promoter Regions, Genetic - genetics Protein Binding Pyrimidines - metabolism SELEX Aptamer Technique Thymine - metabolism Transcription Factors - genetics Transcription Factors - metabolism Uracil - metabolism
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